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  • Rautio, AslakUmeå universitet,Medicin,Department of Medicine, Sunderby Hospital, Luleå, Sweden (författare)

The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events : Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-04-12
  • Sage Publications,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-113823
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-113823URI
  • https://doi.org/10.1177/1479164117703034DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136022853URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Originally included in thesis in manuscript form with title: "The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events : Swedish substudy of the ORIGIN trial" and authors: Aslak Rautio, Hertzel C Gerstein, Jenny Hernestål-Boman, Shun Fu Lee, Linda Garcia Mellbin, Mona Olofsson, Lars Rydén and Kurt Boman
  • Introduction: Fibrinolytic factors, plasminogen activator inhibitor-1, tissue plasminogen activator, tissue plasminogen activator/plasminogen activator-complex and the haemostatic factor von Willebrand factor are known markers of cardiovascular disease. Their plasma levels are adversely affected in patients with dysglycaemia, and glucose normalization with insulin glargine might improve the levels of these factors. Methods: Prespecified Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial (ClinicalTrials.gov number, NCT00069784). Tissue plasminogen activator activity, tissue plasminogen activator antigen, plasminogen activator inhibitor-1 antigen, tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor were analysed at study start, after 2 years and at the end of the study (median follow-up of 6.2 years). Results: Of 129 patients (mean age of 64 ± 7 years, females: 19%), 68 (53%) and 61 (47%) were randomized to the insulin glargine and standard care group, respectively. Allocation to insulin glargine did not significantly affect the studied fibrinolytic markers or von Willebrand factor compared to standard care. Likewise, there were no significant differences in plasminogen activator inhibitor-1, tissue plasminogen activator antigen and von Willebrand factor. During the whole study period, the within-group analysis revealed a curvilinear pattern and significant changes for tissue plasminogen activator/plasminogen activator inhibitor-1 complex, tissue plasminogen activator antigen and von Willebrand factor in the insulin glargine but not in the standard care group. Conclusion: In people with dysglycaemia and other cardiovascular risk factors, basal insulin does not improve the levels of markers of fibrinolysis or von Willebrand factor compared to standard glucose-lowering treatments.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Boman, KurtUmeå universitet,Medicin,Research Unit, Skellefteå Hospital, Skellefteå, Sweden(Swepub:umu)kubo0001 (författare)
  • Gerstein, Hertzel CThe Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada (författare)
  • Hernestål-Boman, JennyUmeå universitet,Medicin,Research Unit, Skellefteå Hospital, Skellefteå, Sweden(Swepub:umu)jeyhel99 (författare)
  • Lee, Shun FuThe Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada (författare)
  • Olofsson, MonaUmeå universitet,Medicin(Swepub:umu)mool0019 (författare)
  • Garcia Mellbin, LindaKarolinska Institutet (författare)
  • Umeå universitetMedicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes & Vascular Disease Research: Sage Publications14:4, s. 345-3521479-16411752-8984

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