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The 12p13.33/RAD52 ...
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Delahaye-Sourdeix, Manon
(author)
The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-03-20
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Public library science,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-116966
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116966URI
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https://doi.org/10.1371/journal.pone.0117639DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Oliver, Javier
(author)
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Timofeeva, Maria N
(author)
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Gaborieau, Valérie
(author)
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Johansson, MattiasGenetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France(Swepub:umu)masmas97
(author)
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Chabrier, Amélie
(author)
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Wozniak, Magdalena B
(author)
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Brenner, Darren R
(author)
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Vallée, Maxime P
(author)
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Anantharaman, Devasena
(author)
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Lagiou, Pagona
(author)
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Holcátová, Ivana
(author)
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Richiardi, Lorenzo
(author)
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Kjaerheim, Kristina
(author)
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Agudo, Antonio
(author)
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Castellsagué, Xavier
(author)
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Macfarlane, Tatiana V
(author)
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Barzan, Luigi
(author)
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Canova, Cristina
(author)
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Thakker, Nalin S
(author)
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Conway, David I
(author)
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Znaor, Ariana
(author)
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Healy, Claire M
(author)
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Ahrens, Wolfgang
(author)
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Zaridze, David
(author)
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Szeszenia-Dabrowska, Neonilia
(author)
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Lissowska, Jolanta
(author)
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Fabianova, Eleonora
(author)
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Mates, Ioan Nicolae
(author)
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Bencko, Vladimir
(author)
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Foretova, Lenka
(author)
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Janout, Vladimir
(author)
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Curado, Maria Paula
(author)
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Koifman, Sergio
(author)
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Menezes, Ana
(author)
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Wünsch-Filho, Victor
(author)
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Eluf-Neto, José
(author)
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Boffetta, Paolo
(author)
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Garrote, Leticia Fernández
(author)
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Serraino, Diego
(author)
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Lener, Marcin
(author)
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Jaworowska, Ewa
(author)
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Lubiński, Jan
(author)
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Boccia, Stefania
(author)
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Rajkumar, Thangarajan
(author)
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Samant, Tanuja A
(author)
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Mahimkar, Manoj B
(author)
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Matsuo, Keitaro
(author)
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Franceschi, Silvia
(author)
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Byrnes, Graham
(author)
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Brennan, Paul
(author)
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McKay, James D
(author)
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Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France
(creator_code:org_t)
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In:PLOS ONE: Public library science10:31932-6203
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Delahaye-Sourdei ...
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Oliver, Javier
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Timofeeva, Maria ...
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Gaborieau, Valér ...
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Johansson, Matti ...
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Chabrier, Amélie
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Holcátová, Ivana
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Richiardi, Loren ...
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Kjaerheim, Krist ...
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Agudo, Antonio
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Castellsagué, Xa ...
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Barzan, Luigi
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Canova, Cristina
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Thakker, Nalin S
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Conway, David I
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Healy, Claire M
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Ahrens, Wolfgang
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Szeszenia-Dabrow ...
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Lissowska, Jolan ...
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Fabianova, Eleon ...
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