The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Samant Tanuja A) > (2015) > The 12p13.33/RAD52 ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Delahaye-Sourdeix, Manon (author)

The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract

Article/chapterEnglish2015

Publisher, publication year, extent ...

2015-03-20
Public library science,2015
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-116966
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116966URI
https://doi.org/10.1371/journal.pone.0117639DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Oliver, Javier (author)
Timofeeva, Maria N (author)
Gaborieau, Valérie (author)
Johansson, MattiasGenetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France(Swepub:umu)masmas97 (author)
Chabrier, Amélie (author)
Wozniak, Magdalena B (author)
Brenner, Darren R (author)
Vallée, Maxime P (author)
Anantharaman, Devasena (author)
Lagiou, Pagona (author)
Holcátová, Ivana (author)
Richiardi, Lorenzo (author)
Kjaerheim, Kristina (author)
Agudo, Antonio (author)
Castellsagué, Xavier (author)
Macfarlane, Tatiana V (author)
Barzan, Luigi (author)
Canova, Cristina (author)
Thakker, Nalin S (author)
Conway, David I (author)
Znaor, Ariana (author)
Healy, Claire M (author)
Ahrens, Wolfgang (author)
Zaridze, David (author)
Szeszenia-Dabrowska, Neonilia (author)
Lissowska, Jolanta (author)
Fabianova, Eleonora (author)
Mates, Ioan Nicolae (author)
Bencko, Vladimir (author)
Foretova, Lenka (author)
Janout, Vladimir (author)
Curado, Maria Paula (author)
Koifman, Sergio (author)
Menezes, Ana (author)
Wünsch-Filho, Victor (author)
Eluf-Neto, José (author)
Boffetta, Paolo (author)
Garrote, Leticia Fernández (author)
Serraino, Diego (author)
Lener, Marcin (author)
Jaworowska, Ewa (author)
Lubiński, Jan (author)
Boccia, Stefania (author)
Rajkumar, Thangarajan (author)
Samant, Tanuja A (author)
Mahimkar, Manoj B (author)
Matsuo, Keitaro (author)
Franceschi, Silvia (author)
Byrnes, Graham (author)
Brennan, Paul (author)
McKay, James D (author)
Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France (creator_code:org_t)

Related titles

In:PLOS ONE: Public library science10:31932-6203

Internet link

Find in a library

PLOS ONE (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Delahaye-Sourdei ...; Oliver, Javier; Timofeeva, Maria ...; Gaborieau, Valér ...; Johansson, Matti ...; Chabrier, Amélie; show more...; Wozniak, Magdale ...; Brenner, Darren ...; Vallée, Maxime P; Anantharaman, De ...; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Loren ...; Kjaerheim, Krist ...; Agudo, Antonio; Castellsagué, Xa ...; Macfarlane, Tati ...; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S; Conway, David I; Znaor, Ariana; Healy, Claire M; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrow ...; Lissowska, Jolan ...; Fabianova, Eleon ...; Mates, Ioan Nico ...; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Pa ...; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Vi ...; Eluf-Neto, José; Boffetta, Paolo; Garrote, Leticia ...; Serraino, Diego; Lener, Marcin; Jaworowska, Ewa; Lubiński, Jan; Boccia, Stefania; Rajkumar, Thanga ...; Samant, Tanuja A; Mahimkar, Manoj ...; Matsuo, Keitaro; Franceschi, Silv ...; Byrnes, Graham; Brennan, Paul; McKay, James D; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: PLOS ONE

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se