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Lifestyle correlates of eight breast cancer-related metabolites : a cross-sectional study within the EPIC cohort

His, Mathilde (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
Viallon, Vivian (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
Dossus, Laure (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
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Schmidt, Julie A. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Travis, Ruth C. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Gunter, Marc J. (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
Overvad, Kim (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Kyrø, Cecilie (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Lécuyer, Lucie (författare)
Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France
Rothwell, Joseph A. (författare)
Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France
Severi, Gianluca (författare)
Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti”, University of Florence, Florence, Italy
Johnson, Theron (författare)
Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Katzke, Verena (författare)
Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Masala, Giovanna (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
Sieri, Sabina (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale dei Tumori di Milano, Milan, Italy
Panico, Salvatore (författare)
Dipartimento Di Medicina Clinica E Chirurgia, Federico Ii University, Naples, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7) Ragusa, Ragusa, Italy
Macciotta, Alessandra (författare)
Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
Boer, Jolanda M. A. (författare)
Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment (RIVM), BA, Bilthoven, Netherlands
Monninkhof, Evelyn M. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Olsen, Karina Standahl (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Nøst, Therese H. (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Sandanger, Torkjel M. (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Agudo, Antonio (författare)
Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Spain
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Amiano, Pilar (författare)
Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain; CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
Colorado-Yohar, Sandra M. (författare)
CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Ardanaz, Eva (författare)
CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Vidman, Linda (författare)
Umeå universitet,Onkologi
Winkvist, Anna (författare)
Umeå universitet,Avdelningen för hållbar hälsa
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer (IARC/WHO), Office of the Director, Lyon, France
Huybrechts, Inge (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
Rinaldi, Sabina (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France
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 (creator_code:org_t)
2021-12-10
2021
Engelska.
Ingår i: BMC Medicine. - : BioMed Central. - 1741-7015. ; 19:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://bmcmedicine....
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786).Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed.Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Anthropometry
Breast cancer
Cross-sectional
Lifestyle
Metabolites

Publikations- och innehållstyp

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