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Nonlinear relations...
Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden).
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Lukanova, Annekatrin (författare)
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- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi
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Stattin, Pär (författare)
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Palmqvist, Richard (författare)
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Lundin, Eva (författare)
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Biessy, Carine (författare)
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Rinaldi, Sabina (författare)
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Riboli, Elio (författare)
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Hallmans, Göran (författare)
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Kaaks, Rudolf (författare)
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Cancer Causes and Control. - 0957-5243 .- 1573-7225. ; 13:6, s. 509-516
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- OBJECTIVE: In this study we test the hypothesis of a nonlinear relationship of IGF-I with indices of body fat such as body mass index (BMI), insulin, and leptin.METHODS: The controls used in three case-control cancer studies nested in the Northern Sweden Health and Disease Cohort, were combined for this analysis. Measurements of plasma IGF-I, IGFBP-3, insulin, and leptin were available for 445 men and 391 women.RESULTS: In both men and women we found the highest mean IGF-I levels in subjects with BMI between 24 and 26. IGF-I concentrations decreased toward BMI < or = 20 and BMI > 30 in men; however, the results for women did not reach statistical significance. The molar ratio of IGF-I/IGFBP-3 showed a similar profile to that of IGF-I, although much less pronounced. The observed peak mean IGF-I levels in the second quintiles of insulin and leptin in men supported these findings. No significant variation of mean IGF-I levels across quintiles of insulin and leptin were observed in women.CONCLUSIONS: The results of this study provide evidence that IGF-I plasma concentrations vary substantially over a wide range of body weight and that the relationship is nonlinear.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Lukanova, Anneka ...
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Söderberg, Stefa ...
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Stattin, Pär
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Palmqvist, Richa ...
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Lundin, Eva
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Biessy, Carine
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visa fler...
-
Rinaldi, Sabina
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Riboli, Elio
-
Hallmans, Göran
-
Kaaks, Rudolf
-
visa färre...
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MEDICIN OCH HÄLS ...
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Cancer Causes an ...
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Umeå universitet