Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

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McKay, James D.International Agency for Research on Cancer, World Health Organization (author)

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-06-12
Nature Publishing Group,2017
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-137794
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137794URI
https://doi.org/10.1038/ng.3892DOI
https://lup.lub.lu.se/record/b5f6bb50-9652-4fb7-821f-5e126bc11baaURI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136091611URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Genome-wide association studies
Lung cancer
Transcriptomics

Added entries (persons, corporate bodies, meetings, titles ...)

Hung, Rayjean J.University of Toronto (author)
Han, YounghunDartmouth College (author)
Zong, XuchenUniversity of Toronto (author)
Carreras-Torres, RobertInternational Agency for Research on Cancer, World Health Organization (author)
Christiani, David C.Harvard Medical School,Dartmouth College (author)
Caporaso, Neil E.National Institutes of Health, United States (author)
Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization (author)
Xiao, XiangjunKarolinska Institutet (author)
Li, YafangDartmouth College (author)
Byun, JinyoungDartmouth College (author)
Dunning, AlisonUniversity of Cambridge (author)
Pooley, Karen A.University of Cambridge (author)
Qian, David C. (author)
Ji, XuemeiDartmouth College (author)
Liu, GeoffreyUniversity of Toronto (author)
Timofeeva, Maria N.International Agency for Research on Cancer, World Health Organization (author)
Bojesen, Stig E.Copenhagen University Hospital (author)
Wu, XifengUniversity of Texas (author)
Le Marchand, LoicUniversity of Hawaii Cancer Center (author)
Albanes, DemetriosNational Institutes of Health, United States (author)
Bickeböller, HeikeUniversity of Göttingen (author)
Aldrich, Melinda C.Vanderbilt University Medical Center (author)
Bush, William S.Case Western Reserve University (author)
Tardon, AdoninaUniversity of Oviedo (author)
Rennert, GadCarmel Medical Center (author)
Teare, M. DawnUniversity of Sheffield (author)
Field, John K.University of Liverpool (author)
Kiemeney, Lambertus A.Radboud University Medical Center (author)
Lazarus, PhilipWashington State University (author)
Haugen, AageNational Institute of Occupational Health, Norway (author)
Lam, StephenBritish Columbia Cancer Agency (author)
Schabath, Matthew B.H. Lee Moffitt Cancer Center & Research Institute (author)
Andrew, Angeline S.Dartmouth College (author)
Shen, HongbingNanjing Medical University (author)
Hong, Yun-ChulSeoul National University (author)
Yuan, Jian-MinUniversity of Pittsburgh Cancer Institute (author)
Bertazzi, Pier AlbertoUniversity of Milan (author)
Pesatori, Angela C.University of Milan (author)
Ye, YuanqingUniversity of Texas (author)
Diao, NancyHarvard T.H. Chan School of Public Health (author)
Su, LiHarvard T.H. Chan School of Public Health (author)
Zhang, RuyangHarvard T.H. Chan School of Public Health (author)
Brhane, YonathanUniversity of Toronto (author)
Leighl, NatashaPrincess Margaret Hospital University of Toronto (author)
Johansen, Jakob S.Copenhagen University Hospital (author)
Mellemgaard, Anders (author)
Saliba, Walid (author)
Haiman, Christopher A. (author)
Wilkens, Lynne R. (author)
Fernandez-Somoano, Ana (author)
Fernandez-Tardon, Guillermo (author)
van der Heijden, Henricus F. M. (author)
Kim, Jin Hee (author)
Dai, Juncheng (author)
Hu, Zhibin (author)
Davies, Michael P. A. (author)
Marcus, Michael W. (author)
Brunnström, HansLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb (author)
Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Muller, David C. (author)
Overvad, Kim (author)
Trichopoulou, Antonia (author)
Tumino, Rosario (author)
Doherty, Jennifer A. (author)
Barnett, Matt P. (author)
Chen, Chu (author)
Goodman, Gary E. (author)
Cox, Angela (author)
Taylor, Fiona (author)
Woll, Penella (author)
Brüske, Irene (author)
Wichmann, H-Erich (author)
Manz, Judith (author)
Muley, Thomas R. (author)
Risch, Angela (author)
Rosenberger, Albert (author)
Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (author)
Johansson, MikaelUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)mijo0025 (author)
Shepherd, Frances A. (author)
Tsao, Ming-Sound (author)
Arnold, Susanne M. (author)
Haura, Eric B. (author)
Bolca, Ciprian (author)
Holcatova, Ivana (author)
Janout, Vladimir (author)
Kontic, Milica (author)
Lissowska, Jolanta (author)
Mukeria, Anush (author)
Ognjanovic, Simona (author)
Orlowski, Tadeusz M. (author)
Scelo, Ghislaine (author)
Swiatkowska, Beata (author)
Zaridze, David (author)
Bakke, Per (author)
Skaug, Vidar (author)
Zienolddiny, Shanbeh (author)
Duell, Eric J. (author)
Butler, Lesley M. (author)
Koh, Woon-Puay (author)
Gao, Yu-Tang (author)
Houlston, Richard S. (author)
McLaughlin, John (author)
Stevens, Victoria L. (author)
Joubert, Philippe (author)
Lamontagne, Maxime (author)
Nickle, David C. (author)
Obeidat, Ma'en (author)
Timens, Wim (author)
Zhu, Bin (author)
Song, LeiNational Institutes of Health, United States(Swepub:lu)med-ls1 (author)
Kachuri, Linda (author)
Artigas, Maria Soler (author)
Tobin, Martin D. (author)
Wain, Louise V. (author)
Rafnar, Thorunn (author)
Thorgeirsson, Thorgeir E. (author)
Reginsson, Gunnar W. (author)
Stefansson, Kari (author)
Hancock, Dana B. (author)
Bierut, Laura J. (author)
Spitz, Margaret R. (author)
Gaddis, Nathan C. (author)
Lutz, Sharon M. (author)
Gu, Fangyi (author)
Johnson, Eric O. (author)
Kamal, Ahsan (author)
Pikielny, Claudio (author)
Zhu, Dakai (author)
Lindström, Sara (author)
Jiang, Xia (author)
Tyndale, Rachel F. (author)
Chenevix-Trench, Georgia (author)
Beesley, Jonathan (author)
Bossé, Yohan (author)
Chanock, Stephen (author)
Brennan, Paul (author)
Landi, Maria Teresa (author)
Amos, Christopher I. (author)
International Agency for Research on Cancer, World Health OrganizationUniversity of Toronto (creator_code:org_t)
SpiroMeta Consortium

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In:Nature Genetics: Nature Publishing Group49:7, s. 1126-11321061-40361546-1718

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By the author/editor: McKay, James D.; Hung, Rayjean J.; Han, Younghun; Zong, Xuchen; Carreras-Torres, ...; Christiani, Davi ...; show more...; Caporaso, Neil E ...; Johansson, Matti ...; Xiao, Xiangjun; Li, Yafang; Byun, Jinyoung; Dunning, Alison; Pooley, Karen A.; Qian, David C.; Ji, Xuemei; Liu, Geoffrey; Timofeeva, Maria ...; Bojesen, Stig E.; Wu, Xifeng; Le Marchand, Loi ...; Albanes, Demetri ...; Bickeböller, Hei ...; Aldrich, Melinda ...; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lamber ...; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthe ...; Andrew, Angeline ...; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A ...; Pesatori, Angela ...; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob ...; Mellemgaard, And ...; Saliba, Walid; Haiman, Christop ...; Wilkens, Lynne R ...; Fernandez-Somoan ...; Fernandez-Tardon ...; van der Heijden, ...; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael ...; Marcus, Michael ...; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, An ...; Tumino, Rosario; Doherty, Jennife ...; Barnett, Matt P.; Chen, Chu; Goodman, Gary E.; Cox, Angela; Taylor, Fiona; Woll, Penella; Brüske, Irene; Wichmann, H-Eric ...; Manz, Judith; Muley, Thomas R.; Risch, Angela; Rosenberger, Alb ...; Grankvist, Kjell; Johansson, Mikae ...; Shepherd, France ...; Tsao, Ming-Sound; Arnold, Susanne ...; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolan ...; Mukeria, Anush; Ognjanovic, Simo ...; Orlowski, Tadeus ...; Scelo, Ghislaine; Swiatkowska, Bea ...; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Sha ...; Duell, Eric J.; Butler, Lesley M ...; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richar ...; McLaughlin, John; Stevens, Victori ...; Joubert, Philipp ...; Lamontagne, Maxi ...; Nickle, David C.; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Kachuri, Linda; Artigas, Maria S ...; Tobin, Martin D.; Wain, Louise V.; Rafnar, Thorunn; Thorgeirsson, Th ...; Reginsson, Gunna ...; Stefansson, Kari; Hancock, Dana B.; Bierut, Laura J.; Spitz, Margaret ...; Gaddis, Nathan C ...; Lutz, Sharon M.; Gu, Fangyi; Johnson, Eric O.; Kamal, Ahsan; Pikielny, Claudi ...; Zhu, Dakai; Lindström, Sara; Jiang, Xia; Tyndale, Rachel ...; Chenevix-Trench, ...; Beesley, Jonatha ...; Bossé, Yohan; Chanock, Stephen; Brennan, Paul; Landi, Maria Ter ...; Amos, Christophe ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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