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  • Wahlin, BengtUmeå universitet,Reumatologi (författare)

Atherosclerosis in rheumatoid arthritis : associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Clinical and Experimental Rheumatology S.A.S.2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-158135
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158135URI
  • https://doi.org/10.55563/clinexprheumatol/gs3o43DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146705336URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Previously included in thesis in manuscript form. 
  • Objectives: Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aims of this study were to study the associations between subsets of T-cells, subclinical atherosclerosis assessed by intima-media thickness (IMT) and serological status for CMV in patients with RA.Methods: Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were included in a prospective study of atherosclerosis. Controls matched for age and sex were also included (n=44). Ultrasound measurement of IMT in the common carotid artery was undertaken at inclusion (T0), after 1.5 years (T1.5) and after 11 years (T11). At T11, flow-cytometry analysis was undertaken to investigate subsets of T-cells. Serological analysis for CMV was undertaken from samples collected at T0.Results: At T0, 66% of the patients and controls were CMV immunoglobulin G-positive. CMV-IgG positive patients had a significantly more rapid increase in IMT at T1.5, compared with controls and CMV-IgG negative patients. CMV-IgG positive patients had a significantly higher percentage of T-cells lacking CD28 (both CD4+CD28null and CD8+CD28null T-cells) than CMV-IgG negative patients. Increased levels of CD4+CD28null and CD8+CD28null T-cells were significantly associated with IMT at T11, adjusted for systolic blood pressure. CX3CR1 was expressed in CD4+ and CD8+ CD28null T-cells, but CX3CR1 per se was not associated with increased IMT.Conclusions: Presence of CMV IgG-antibodies in patients with RA is associated with altered T-cell-populations and an increased burden of atherosclerosis. A possible protective effect of antiviral treatment in CMV-positive patients with new-onset RA should be considered.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Fasth, Andreas (författare)
  • Karp, KjellUmeå universitet,Klinisk fysiologi(Swepub:umu)kjka0001 (författare)
  • Lejon, Kristina,1967-Umeå universitet,Immunologi/immunkemi(Swepub:umu)krle0001 (författare)
  • Malmström, VivianneKarolinska Institutet (författare)
  • Rahbar, AfsarKarolinska Institutet (författare)
  • Wållberg-Jonsson, Solveig,1953-Umeå universitet,Reumatologi(Swepub:umu)sowa0001 (författare)
  • Södergren, Anna,1977-Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)anayxt97 (författare)
  • Umeå universitetReumatologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical and Experimental Rheumatology: Clinical and Experimental Rheumatology S.A.S.39:3, s. 578-5860392-856X1593-098X

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