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Atherosclerosis in ...
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Wahlin, BengtUmeå universitet,Reumatologi
(författare)
Atherosclerosis in rheumatoid arthritis : associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Clinical and Experimental Rheumatology S.A.S.2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-158135
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158135URI
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https://doi.org/10.55563/clinexprheumatol/gs3o43DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146705336URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Previously included in thesis in manuscript form.
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Objectives: Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aims of this study were to study the associations between subsets of T-cells, subclinical atherosclerosis assessed by intima-media thickness (IMT) and serological status for CMV in patients with RA.Methods: Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were included in a prospective study of atherosclerosis. Controls matched for age and sex were also included (n=44). Ultrasound measurement of IMT in the common carotid artery was undertaken at inclusion (T0), after 1.5 years (T1.5) and after 11 years (T11). At T11, flow-cytometry analysis was undertaken to investigate subsets of T-cells. Serological analysis for CMV was undertaken from samples collected at T0.Results: At T0, 66% of the patients and controls were CMV immunoglobulin G-positive. CMV-IgG positive patients had a significantly more rapid increase in IMT at T1.5, compared with controls and CMV-IgG negative patients. CMV-IgG positive patients had a significantly higher percentage of T-cells lacking CD28 (both CD4+CD28null and CD8+CD28null T-cells) than CMV-IgG negative patients. Increased levels of CD4+CD28null and CD8+CD28null T-cells were significantly associated with IMT at T11, adjusted for systolic blood pressure. CX3CR1 was expressed in CD4+ and CD8+ CD28null T-cells, but CX3CR1 per se was not associated with increased IMT.Conclusions: Presence of CMV IgG-antibodies in patients with RA is associated with altered T-cell-populations and an increased burden of atherosclerosis. A possible protective effect of antiviral treatment in CMV-positive patients with new-onset RA should be considered.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fasth, Andreas
(författare)
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Karp, KjellUmeå universitet,Klinisk fysiologi(Swepub:umu)kjka0001
(författare)
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Lejon, Kristina,1967-Umeå universitet,Immunologi/immunkemi(Swepub:umu)krle0001
(författare)
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Malmström, VivianneKarolinska Institutet
(författare)
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Rahbar, AfsarKarolinska Institutet
(författare)
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Wållberg-Jonsson, Solveig,1953-Umeå universitet,Reumatologi(Swepub:umu)sowa0001
(författare)
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Södergren, Anna,1977-Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)anayxt97
(författare)
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Umeå universitetReumatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical and Experimental Rheumatology: Clinical and Experimental Rheumatology S.A.S.39:3, s. 578-5860392-856X1593-098X
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