Tyck till om SwePub Sök
här!
Search: WFRF:(Manning Alisa)
> (2015-2019) >
Variation in maturi...
Variation in maturity-onset diabetes of the young genes influence response to interventions for diabetes prevention
-
- Billings, Liana K. (author)
- Harvard Medical School,Massachusetts General Hospital,NorthShore University HealthSystem
-
- Jablonski, Kathleen A (author)
- George Washington University
-
- Warner, A. Sofia (author)
- Massachusetts General Hospital
-
show more...
-
- Cheng, Yu Chien (author)
- NorthShore University HealthSystem,University of Chicago
-
- McAteer, Jarred B. (author)
- Massachusetts General Hospital
-
- Tipton, Laura (author)
- George Washington University
-
Shuldiner, Alan R. (author)
-
- Ehrmann, David A (author)
- University of Chicago
-
- Manning, Alisa K. (author)
- Broad Institute,Harvard Medical School,Massachusetts General Hospital
-
- Dabelea, Dana (author)
- Colorado School of Public Health
-
- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
-
- Kahn, Steven E (author)
- University of Washington
-
- Pollin, Toni I (author)
- University of Maryland, Baltimore
-
- Knowler, William C (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
-
- Altshuler, David (author)
- Harvard Medical School,Broad Institute
-
- Florez, Jose C. (author)
- Massachusetts General Hospital,Harvard Medical School,George Washington University,Broad Institute
-
show less...
-
(creator_code:org_t)
-
- 2017-04-27
- 2017
- English 12 s.
-
In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 102:8, s. 2678-2689
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the Diabetes Prevention Program (DPP), involving 27 US academic institutions. We genotyped 22 missense and 221 common variants in the MODY-causing genes in the participants in the DPP. Participants and Interventions: The study included 2806 genotyped DPP participants randomized to receive intensive lifestyle intervention (n = 935), metformin (n = 927), or placebo (n = 944). Main Outcome Measures: Association of MODY genetic variants with diabetes incidence at a median of 3 years and measures of 1-year β-Cell function, insulinogenic index, and oral disposition index. Analyses were stratified by treatment group for significant single-nucleotide polymorphism 3 treatment interaction (Pint, 0.05). Sequence kernel association tests examined the association between an aggregate of rare missense variants and insulinogenic traits. Results: After 1 year, the minor allele of rs3212185 (HNF4A) was associated with improved β-Cell function in the metformin and lifestyle groups but not the placebo group; the minor allele of rs6719578 (NEUROD1) was associated with an increase in insulin secretion in the metformin group but not in the placebo and lifestyle groups. Conclusions: These results provide evidence that genetic variation among MODY genes may influence response to insulin-sensitizing interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Billings, Liana ...
-
Jablonski, Kathl ...
-
Warner, A. Sofia
-
Cheng, Yu Chien
-
McAteer, Jarred ...
-
Tipton, Laura
-
show more...
-
Shuldiner, Alan ...
-
Ehrmann, David A
-
Manning, Alisa K ...
-
Dabelea, Dana
-
Franks, Paul W.
-
Kahn, Steven E
-
Pollin, Toni I
-
Knowler, William ...
-
Altshuler, David
-
Florez, Jose C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University