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Sökning: WFRF:(Liloglou Triantafillos) > Kiemeney Lambertus A > Timens Wim > Genome-wide associa...

  • Lesseur, CorinaSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States (författare)

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-03-05
  • Public Library of Science (PLoS),2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-181786
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181786URI
  • https://doi.org/10.1371/journal.pgen.1009254DOI
  • https://lup.lub.lu.se/record/f1281cc1-b007-45f2-87f6-45aaffe1c8beURI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ferreiro-Iglesias, AidaSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • McKay, James D.Section of Genetics, Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Bossé, YohanDepartment of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Canada (författare)
  • Johansson, MattiasSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Gaborieau, ValerieSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Landi, Maria TeresaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Christiani, David C.Department of Environmental Health, Harvard TH Chan School of Public Health, Massachusetts General Hospital, MA, Boston, United States,University of Washington (författare)
  • Caporaso, Neil C.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Bojesen, Stig E.Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark (författare)
  • Amos, Christopher I.Department of Medicine, Baylor college of Medicine, TX, Houston, United States (författare)
  • Shete, SanjayDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, TX, Houston, United States (författare)
  • Liu, GeoffreyLunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, Canada (författare)
  • Rennert, GadiClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel (författare)
  • Albanes, DemetriosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
  • Aldrich, Melinda C.Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States (författare)
  • Tardon, AdoninaFaculty of Medicine, University of Oviedo, CIBERESP, Oviedo, Spain (författare)
  • Chen, ChuDepartment of Epidemiology, University of Washington School of Public Health and Community Medicine, WA, Seattle, United States (författare)
  • Triantafillos, LiloglouInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University (författare)
  • Field, John K.Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University (författare)
  • Teare, Marion DawnSchool of Health and Related Research, University Of Sheffield, Sheffield, United Kingdom,Sheffield Hallam University (författare)
  • Kiemeney, Lambertus A.Radboud University Medical Center, Nijmegen, Netherlands (författare)
  • Diergaarde, BrendaDepartment of Human Genetics, University of Pittsburgh, PA, Pittsburgh, United States; Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Ferris, Robert L.UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Zienolddiny, ShanbehNational Institute of Occupational Health, Oslo, Norway (författare)
  • Lam, StephenBritish Columbia Cancer Agency, Vancouver, Canada (författare)
  • Olshan, Andrew F.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States (författare)
  • Weissler, Mark C.Department of Otolaryngology/Head and Neck Surgery, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States (författare)
  • Lacko, MartinDepartment of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands (författare)
  • Risch, AngelaUniversity of Salzburg, Department of Biosciences and Cancer Cluster Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany (författare)
  • Bickeböller, HeikeDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany (författare)
  • Ness, Andy R.National Institute for Health Research (NIHR), Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; Bristol Dental School, University of Bristol, Bristol, United Kingdom (författare)
  • Thomas, SteveBristol Dental School, University of Bristol, Bristol, United Kingdom (författare)
  • Le Marchand, LoicEpidemiology Program, University of Hawaii Cancer Center, University of Hawaii, HI, Honolulu, United States (författare)
  • Schabath, Matthew B.Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States (författare)
  • Wünsch-Filho, VictorFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil (författare)
  • Tajara, Eloiza H.Department of Molecular Biology, School of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil (författare)
  • Andrew, Angeline S.Biomedical Data Science, Geisel School of Medicine at Dartmouth, Dartmouth College, NH, Hanover, United States (författare)
  • Clifford, Gary M.Infections Section, Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Lazarus, PhilipDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States (författare)
  • Grankvist, KjellUmeå University,Umeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (författare)
  • Johansson, MikaelUmeå University,Umeå universitet,Onkologi(Swepub:umu)mijo0025 (författare)
  • Arnold, SusanneMarkey Cancer Center, University of Kentucky, KY, Lexington, United States (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
  • Brunnström, HansLund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb (författare)
  • Boccia, StefaniaSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy; Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy,Catholic University of the Sacred Heart, Rome (författare)
  • Cadoni, GabriellaDipartimento Patologia Testa Collo e Organi di Senso, Istituto di Clinica Otorinolaringoiatrica, Università Cattolica del Sacro Cuore, Roma, Italy; Dipartimento di Scienze dell’Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy (författare)
  • Timens, WimDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; GRIAC Research Institute, University of Groningen, Groningen, Netherlands (författare)
  • Obeidat, Ma'enCentre for Heart Lung Innovation, St Paul’s Hospital, The University of British Columbia, Vancouver, Canada (författare)
  • Xiao, XiangjunDepartment of Medicine, Baylor college of Medicine, TX, Houston, United States (författare)
  • Houlston, Richard S.Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom (författare)
  • Hung, Rayjean J.Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada (författare)
  • Brennan, PaulSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United StatesSection of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France (creator_code:org_t)
  • et al.

Sammanhörande titlar

  • Ingår i:PLOS Genetics: Public Library of Science (PLoS)17:31553-73901553-7404

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