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Sökning: onr:"swepub:oai:DiVA.org:umu-185763" > Fjell Anders M. > The genetic organiz...

  • Fjell, Anders M.Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (författare)

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • eLife Sciences Publications Ltd,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-185763
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185763URI
  • https://doi.org/10.7554/eLife.66466DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single nucleotide polymorphisms-based analyses of 38127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Grydeland, HåkonResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Wang, YunpengResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Amlien, IngeResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Bartrés-Faz, DavidDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain (författare)
  • Brandmaier, Andreas M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom (författare)
  • Düzel, SandraCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Elman, JeremyCenter for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States (författare)
  • Franz, CarolCenter for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States (författare)
  • Håberg, Asta K.Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway (författare)
  • Kietzmann, Tim C.MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands (författare)
  • Kievit, Rogier A.MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom (författare)
  • Kremen, William S.Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States; Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States (författare)
  • Krogsrud, Stine K.Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Kühn, SimoneCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany (författare)
  • Lindenberger, UlmanCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom (författare)
  • Macià, DidacDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain (författare)
  • Mowinckel, Athanasia M.Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Nyberg, Lars,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway(Swepub:umu)lany0001 (författare)
  • Panizzon, Matthew S.Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States (författare)
  • Solé-Padullés, CristinaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain (författare)
  • Sørensen, ØysteinResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Westerhausen, RenéResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (författare)
  • Walhovd, Kristine B.Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayResearch Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:eLIFE: eLife Sciences Publications Ltd102050-084X

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