Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: WFRF:(Nordmark Gunnel) > Systemic phenotype ...

Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

Acar-Denizli, N. (författare): Univ Politecn Cataluna, Dept Stat & Opera tions Res, Barcelona, Spain.,University of Barcelona

Horvath, I. -F (författare): University of Debrecen

Mandl, Thomas (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp Malmö, Dept Rheumatol, Lund, Sweden.

visa fler...

Priori, R. (författare): Sapienza Univ Rome, Rheumatol Clin, Dept Internal Med & Med Specialties, Rome, Italy.,Sapienza University of Rome

Vissink, A. (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands.,Hanze University of Applied Sciences

Hernandez-Molina, G. (författare): Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico.,Instituto Nacional de Ciencias Médicas y Nutrición

Armagan, B. (författare): Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey.,Hacettepe University

Praprotnik, S. (författare): Univ Med Ctr, Dept Rheumatol, Ljubljana, Slovenia.,McMaster University Medical Centre,Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India.

Sebastian, A. (författare): Wroclaw Med Univ, Dept Rheumatol & Internal Med, Wroclaw, Poland.,Wrocław Medical University

Bartoloni, E. (författare): Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy.,University of Perugia

Rischmueller, M. (författare): Univ Adelaide, Queen Elizabeth Hosp, Dept Rheumatol, Discipline Med, Adelaide, SA, Australia.,University of Adelaide

Pasoto, S. G. (författare): Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Rheumatol Div, Sao Paulo, Brazil.,Hospital das Clínicas da Universidade de São Paulo,University Hospital 'Santa Maria della Misericordia',Univ Hosp Santa Maria della Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.

Nordmark, Gunnel (författare): Uppsala University,Uppsala universitet,Reumatologi

Nakamura, H. (författare): Nagasaki Univ, Grad Sch Biomed Sci, Div Adv Prevent Med Sci, Dept Immunol & Rheumatol, Nagasaki, Japan.,Nagasaki University

Fernandes Moca Trevisani, V. (författare): Univ Fed Sao Paulo, Sao Paulo, Brazil.,Federal University of São Paulo,Federal University of Espírito Santo,Hosp Clin, Dept Rheumatol, San Lorenzo, Paraguay.,Univ Fed Espirito Santo, Dept Med, Vitoria, Brazil.

Retamozo, S. (författare): Inst Modelo Cardiol Privado SRL, Cordoba, Argentina.;Inst Univ Ciencias Biomed Cordoba IUCBC, Cordoba, Argentina.,Instituto Modelo de Cardiología Privado SRL,Univ Paris Sud, Hop Univ Paris Sud, AP HP, Ctr Immunol Viral Infect & Autoimmune Dis,INSERM, Paris, France.,Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain.

Carsons, S. E. (författare): NYU Long Isl Sch Med, Div Rheumatol Allergy & Immunol, Mineola, NY USA.

Maure-Noia, B. (författare): Complexo Hosp Univ Vigo, Dept Autoimmune Dis, Vigo, Spain.,University Hospital Complex Of Vigo

Sanchez-Berna, I. (författare): Hosp Rey Juan Carlos de Mostoles, Dept Internal Med, Madrid, Spain.,Hospital Rey Juan Carlos de Móstoles

Lopez-Dupla, M. (författare): Hosp Joan 23, Dept Internal Med, Tarragona, Spain.,Hospital Joan XXIII

Fonseca-Aizpuru, E. (författare): Hosp Cabuenes, Dept Internal Med, Gijon, Spain.,University Hospital Cabueñes

Melchor Diaz, S. (författare): Hosp 12 Octubre, Dept Rheumatol, Madrid, Spain.,Royal Observatory of Madrid,Univ Paris VII, Hop Lariboisiere, AP HP, Serv Med Interne 2, Paris, France.

Vazquez, M. (författare): Hosp Clin, Dept Rheumatol, San Lorenzo, Paraguay.,Hospital de Clínicas "José de San Martín"

Diaz Cuiza, P. E. (författare): Seguro Social Univ, Dept Reumatol, Sucre, Bolivia.;Consultorio Privado Reumatol, Sucre, Bolivia.

de Miguel Campo, B. (författare): Hosp 12 Octubre, Dept Internal Med, Madrid, Spain.,Univ Pisa, Rheumatol Unit, Pisa, Italy.

Ng, W. -F (författare): University of Newcastle upon Tyne

Rasmussen, A. (författare): Oklahoma Med Res Fdn, Genes & Human Dis Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.

Dong, X. (författare): Peking Union Med Coll Hosp, Dept Rheumatol, Beijing, Peoples R China.,Peking Union Medical College

Li, X. (författare): Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China.,Anhui Provincial Hospital

Baldini, C. (författare): Univ Pisa, Rheumatol Unit, Pisa, Italy.,University of Pisa

Seror, R. (författare): Univ Paris Sud, Hop Univ Paris Sud, AP HP, Ctr Immunol Viral Infect & Autoimmune Dis,INSERM, Paris, France.,Center For Immunology Of Viral Infections And Autoimmune Diseases

Gottenberg, J. -E (författare): University of Strasbourg

Kruize, A. A. (författare): Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands.,University Medical Center Utrecht

Sandhya, P. (författare): Christian Med Coll & Hosp, Dept Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India.,Christian Medical College & Hospital

Gandolfo, S. (författare): Univ Hosp Santa Maria della Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy.

Kwok, S. -K (författare): Catholic University of Korea

Kvarnstrom, M. (författare): Karolinska Institutet,Karolinska Inst, Div Expt Rheumatol, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.

Solans, R. (författare): Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain.,Vall d'Hebron University Hospital

Sene, D. (författare): Univ Paris VII, Hop Lariboisiere, AP HP, Serv Med Interne 2, Paris, France.

Suzuki, Y. (författare): Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.,Kanazawa University Hospital

Isenberg, D. A. (författare): UCL, Div Med, Ctr Rheumatol, London, England.,University College London Hospital

Valim, V. (författare): Univ Fed Espirito Santo, Dept Med, Vitoria, Brazil.,Brest Univ, Rheumatol Dept, INSERM 1227, Brest, France.

Hofauer, B. (författare): Tech Univ Munich, Otorhinolaryngol Head & Neck Surg, Munich, Germany.,Technical University of Munich,Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands.

Giacomelli, R. (författare): Univ Aquila, Sch Med, Clin Unit Rheumatol, Laquila, Italy.,University of L'Aquila

Devauchelle-Pensec, V. (författare): Brest Univ, Rheumatol Dept, INSERM 1227, Brest, France.,University Hospital of Brest

Atzeni, F. (författare): Univ Messina, IRCCS Galeazzi Orthopaed Inst, Milan & Rheumatol Unit, Messina, Italy.,University of Messina

Gheita, T. A. (författare): Cairo Univ, Kasr Al Ainy Sch Med, Rheumatol Dept, Cairo, Egypt.,Cairo University

Morel, J. (författare): Teaching Hosp, Dept Rheumatol, Montpellier, France.;Univ Montpellier, Montpellier, France.

Izzo, R. (författare): Sapienza Univ Rome, Rheumatol Clin, Dept Internal Med & Med Specialties, Rome, Italy.,Sapienza University of Rome

Kalyoncu, U. (författare): Hacettepe Univ, Fac Med, Dept Internal Med, Ankara, Turkey.

Szanto, A. (författare): Univ Debrecen, Div Clin Immunol, Fac Med, Debrecen, Hungary.

Olsson, Peter (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp Malmö, Dept Rheumatol, Lund, Sweden.

Bootsma, H. (författare): Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands.,University of Groningen

Ramos-Casals, M. (författare): Univ Barcelona, Sjogren Syndrome Res Grp AGAUR, Lab Autoimmune Dis Josep Font, IDIBAPS CELLEX,Dept Autoimmune Dis,ICMiD,Hosp Cli, Barcelona, Spain.,Hospital Clínic of Barcelona

Kostov, B. (författare): Univ Politecn Cataluna, Dept Stat & Opera tions Res, Barcelona, Spain.;Consorci Atencio Primaria Salut Barcelona Esquerr, Primary Care Ctr Corts, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Primary Healthcare Transversal Res Grp, Barcelona, Spain.,Polytechnic University of Catalonia

Brito-Zeron, P. (författare): Univ Barcelona, Sjogren Syndrome Res Grp AGAUR, Lab Autoimmune Dis Josep Font, IDIBAPS CELLEX,Dept Autoimmune Dis,ICMiD,Hosp Cli, Barcelona, Spain.;Hosp CIMA Sanitas, Dept Med, Autoimmune Dis Unit, Barcelona, Spain.,Hospital Clínic of Barcelona,Autonomous University of Barcelona

visa färre...

Univ Politecn Cataluna, Dept Stat & Opera tions Res, Barcelona, Spain University of Barcelona (creator_code:org_t)

CLINICAL & EXPER RHEUMATOLOGY, 2020
2020
Engelska.
Ingår i: Clinical and Experimental Rheumatology. - : CLINICAL & EXPER RHEUMATOLOGY. - 0392-856X .- 1593-098X. ; 38:4; Suppl. 126, s. S85-S94

Relaterad länk:: https://www.clinexpr...; visa fler...; https://pubmed.ncbi....; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Objective: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjogren's syndrome (pSS) fulfilling the 2002 classification criteria.Methods: The Big Data Sjogren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on clinical research in SS of the 5 continents was collected. Combination patterns of anti-Ro/SSA-La/SSB antibodies at the time of diagnosis defined the following four immunological phenotypes: double positive (combined Ro/SSA and La/SSB,) isolated anti-Ro/SSA, isolated anti-La/SSB, and immunonegative.Results: The cohort included 12,084 patients (11,293 females, mean 52.4 years) with recorded ESSDAI scores available. Among them, 279 (2.3%) had isolated anti-La/SSB antibodies. The mean total ESSDAI score at diagnosis of patients with pSS carrying isolated anti-La/SSB was 6.0, and 80.4% of patients had systemic activity (global ESSDAI score >= 1) at diagnosis. The domains with the highest frequency of active patients were the biological (42.8%), glandular (36.8%) and articular (31.2%) domains. Patients with isolated anti-La/ SSB showed a higher frequency of active patients in all ESSDAI domains but two (articular and peripheral nerve) in comparison with immune-negative patients, and even a higher absolute frequency in six clinical ESSDAI domains in comparison with patients with isolated anti-Ro/SSA. In addition, patients with isolated anti-La/SSB showed a higher frequency of active patients in two ESSDAI domains (pulmonary and glandular) with respect to the most active immunological subset (double-positive antibodies). Meanwhile, systemic activity detected in patients with isolated anti-La/SSB was overwhelmingly low. Even in ESSDAI domains where patients with isolated anti-La/SSB had the highest frequencies of systemic activity (lymphadenopathy and muscular), the percentage of patients with moderate or high activity was lower in comparison with the combined Ro/SSA and La/SSB group.Conclusion: Patients carrying isolated La/SSB antibodies represent a very small subset of patients with a systemic SS phenotype characterised by a significant frequency of active patients in most clinical ESSDAI domains but with a relative low frequency of the highest severe organ-specific involvements. Primary SS still remains the best clinical diagnosis for this subset of patients.

Hitta via bibliotek

Clinical and Experimental Rheumatology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Acar-Denizli, N.; Horvath, I. -F; Mandl, Thomas; Priori, R.; Vissink, A.; Hernandez-Molina ...; visa fler...; Armagan, B.; Praprotnik, S.; Sebastian, A.; Bartoloni, E.; Rischmueller, M.; Pasoto, S. G.; Nordmark, Gunnel; Nakamura, H.; Fernandes Moca T ...; Retamozo, S.; Carsons, S. E.; Maure-Noia, B.; Sanchez-Berna, I ...; Lopez-Dupla, M.; Fonseca-Aizpuru, ...; Melchor Diaz, S.; Vazquez, M.; Diaz Cuiza, P. E ...; de Miguel Campo, ...; Ng, W. -F; Rasmussen, A.; Dong, X.; Li, X.; Baldini, C.; Seror, R.; Gottenberg, J. - ...; Kruize, A. A.; Sandhya, P.; Gandolfo, S.; Kwok, S. -K; Kvarnstrom, M.; Solans, R.; Sene, D.; Suzuki, Y.; Isenberg, D. A.; Valim, V.; Hofauer, B.; Giacomelli, R.; Devauchelle-Pens ...; Atzeni, F.; Gheita, T. A.; Morel, J.; Izzo, R.; Kalyoncu, U.; Szanto, A.; Olsson, Peter; Bootsma, H.; Ramos-Casals, M.; Kostov, B.; Brito-Zeron, P.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

Artiklar i publikationen: Clinical and Exp ...

Av lärosätet: Uppsala universitet; Lunds universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub