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Sökning: WFRF:(Besevic J) > Metabolic signature...

Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort

Rothwell, Joseph A. (författare)
Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France
Murphy, Neil (författare)
International Agency for Research on Cancer, Lyon, France
Bešević, Jelena (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Kliemann, Nathalie (författare)
International Agency for Research on Cancer, Lyon, France
Jenab, Mazda (författare)
International Agency for Research on Cancer, Lyon, France
Ferrari, Pietro (författare)
International Agency for Research on Cancer, Lyon, France
Achaintre, David (författare)
International Agency for Research on Cancer, Lyon, France
Gicquiau, Audrey (författare)
International Agency for Research on Cancer, Lyon, France
Vozar, Béatrice (författare)
International Agency for Research on Cancer, Lyon, France
Scalbert, Augustin (författare)
International Agency for Research on Cancer, Lyon, France
Huybrechts, Inge (författare)
International Agency for Research on Cancer, Lyon, France
Freisling, Heinz (författare)
International Agency for Research on Cancer, Lyon, France
Prehn, Cornelia (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Adamski, Jerzy (författare)
Research Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
Cross, Amanda J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Pala, Valeria Maria (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Boutron-Ruault, Marie-Christine (författare)
Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
Dahm, Christina C. (författare)
Department of Public Health, Aarhus University, Aarhus C, Denmark
Overvad, Kim (författare)
Department of Public Health, Aarhus University, Aarhus C, Denmark
Gram, Inger Torhild (författare)
Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Sandanger, Torkjel M. (författare)
Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Skeie, Guri (författare)
Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Jakszyn, Paula (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
Tsilidis, Kostas K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Aleksandrova, Krasimira (författare)
Nutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Hughes, David J. (författare)
School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
van Guelpen, Bethany (författare)
Umeå universitet,Onkologi
Bodén, Stina (författare)
Umeå universitet,Onkologi
Sánchez, Maria-José (författare)
CIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Schmidt, Julie A. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Katzke, Verena (författare)
Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
Kühn, Tilman (författare)
Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
Colorado-Yohar, Sandra (författare)
Department of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
Bueno-de-Mesquita, Bas (författare)
Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands
Vineis, Paolo (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
Eriksen, Anne Kirstine (författare)
Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
Aune, Dagfinn (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, Lyon, France
Severi, Gianluca (författare)
Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
Chajès, Véronique (författare)
International Agency for Research on Cancer, Lyon, France
Gunter, Marc J. (författare)
International Agency for Research on Cancer, Lyon, France
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 (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:5, s. e1061-e1082
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Colorectal Neoplasm
Risk Factors
Targeted Metabolomics
World Cancer Research Fund/American Institute for Cancer Research Recommendations
Oncology
onkologi

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