Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk

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Tian, YuDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China (författare)

Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk

Artikel/kapitelEngelska2022

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2022-05-05
Oxford University Press,2022
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LIBRIS-ID:oai:DiVA.org:umu-198687
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198687URI
https://doi.org/10.1093/jnci/djac094DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489519URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150486069URI

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BACKGROUND: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. METHODS: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants. RESULTS: The use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P < 1.2 × 10-4). CONCLUSION: Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.

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Kim, Andre E.Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Bien, Stephanie A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Qu, ConghuiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Harrison, Tabitha A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Carreras-Torres, RobertColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
Díez-Obrero, VirginiaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
Dimou, NikiNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Drew, David A.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States (författare)
Hidaka, AkihisaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Huyghe, Jeroen R.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Jordahl, Kristina M.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
Morrison, JohnDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Murphy, NeilNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Obón-Santacana, MireiaColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
Ulrich, Cornelia M.Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Ose, JenniferHuntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Peoples, Anita R.Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Ruiz-Narvaez, Edward A.Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States (författare)
Shcherbina, AnnaBiomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States (författare)
Stern, Mariana C.Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Su, Yu-RuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States (författare)
van Duijnhoven, Franzel J BDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands (författare)
Arndt, VolkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Baurley, James W.Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia (författare)
Berndt, Sonja I.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Bishop, D TimothyLeeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom (författare)
Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Buchanan, Daniel D.Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia (författare)
Chan, Andrew T.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
Figueiredo, Jane C.Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Gallinger, StevenLunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada (författare)
Gruber, Stephen B.Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105 (författare)
Hoffmeister, MichaelDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Jenkins, Mark A.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia (författare)
Joshi, Amit D.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
Keku, Temitope O.Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States (författare)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi(Swepub:uu)susla720 (författare)
Le Marchand, LoicUniversity of Hawaii Cancer Center, HI, Honolulu, United States (författare)
Li, LiDepartment of Family Medicine, University of Virginia, VA, Charlottesville, United States (författare)
Giles, Graham G.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia (författare)
Milne, Roger L.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia (författare)
Nan, HongmeiDepartment of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States (författare)
Nassir, RamiDepartment of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia (författare)
Ogino, ShujiBroad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States (författare)
Budiarto, ArifBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia (författare)
Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
Potter, John D.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand (författare)
Prentice, Ross L.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States (författare)
Rennert, GadDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel (författare)
Sakoda, Lori C.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States (författare)
Schoen, Robert E.Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States (författare)
Slattery, Martha L.Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States (författare)
Thibodeau, Stephen N.Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States (författare)
van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
White, EmilyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Medicinsk epidemiologi(Swepub:uu)alwol516 (författare)
Woods, Michael O.Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada (författare)
Wu, Anna H.Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Campbell, Peter T.Department of Population Science, American Cancer Society, GA, Atlanta, United States (författare)
Casey, GrahamCenter for Public Health Genomics, University of Virginia, VA, Charlottesville, United States (författare)
Conti, David V.Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Kundaje, AnshulDepartment of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States (författare)
Lewinger, Juan PabloDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Moreno, VictorColorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain (författare)
Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
Pardamean, BensBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia (författare)
Thomas, Duncan C.Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Tsilidis, Konstantinos K.Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece (författare)
Peters, UlrikePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
Gauderman, W JamesDivision of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States (författare)
Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, ChinaDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (creator_code:org_t)

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Ingår i:Journal of the National Cancer Institute: Oxford University Press114:8, s. 1135-11480027-88741460-2105

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