Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

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Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort

Claeys, Liesel (författare): Centre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

De Saeger, Sarah (författare): Centre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Department of Biotechnology and Food Technology, Faculty of Science, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa

Scelo, Ghislaine (författare): Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

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Biessy, Carine (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

Casagrande, Corinne (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

Nicolas, Genevieve (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

Korenjak, Michael (författare): Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

Fervers, Beatrice (författare): Department Prevention Cancer Environment, Centre Léon Bérard, U1296 INSERM Radiation, Defense, Health and Environment, 28 Rue Laënnec, Lyon, France

Heath, Alicia K. (författare): Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus ,Norfolk Place, London, United Kingdom

Krogh, Vittorio (författare): Epidemiology and Prevention Unit, Fondazione IRCCS Istituto dei Tumori di Milano, 1 Via Venezian, Milan, Italy,Istituto Nazionale dei Tumori

Luján-Barroso, Leila (författare): Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, Granvia de L-Hospitalet 199-203, 08908 L'Hospitalet de Llobregat, Spain

Castilla, Jesús (författare): Navarra Public Health Institute-IdiSNA, Leyre 15, Pamplona, Spain; Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), C. Monforte de Lemos 3-5, Madrid, Spain,CIBER Epidemiology and Public Health (CIBERESP)

Ljungberg, Börje, Professor, 1949- (författare): Umeå University,Umeå universitet,Urologi och andrologi

Rodriguez-Barranco, Miguel (författare): Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), C. Monforte de Lemos 3-5, Madrid, Spain; alusian School of Public Health (EASP), Cta. del Observatorio, Granada, Spain; Instituto de Investigación Biosanitaria ibs. Granada, 15 Av. de Madrid, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)

Ericson, Ulrika (författare): Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups

Santiuste, Carmen (författare): Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), C. Monforte de Lemos 3-5, Madrid, Spain; Department of Epidemiology, Murcia Regional Heath Council, IMIB-Arrixaca, 11 Ronda de Levante, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)

Catalano, Alberto (författare): Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Italy

Overvad, Kim (författare): Department of Public Health, Aarhus University, Bartholins Allé 2, Denmark

Brustad, Magritt (författare): Department of Community Medicine, Arctic University of Norway, Hansines veg 18, Norway,UiT The Arctic University of Norway, Tromsø

Gunter, Marc J. (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

Zavadil, Jiri (författare): Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

De Boevre, Marthe (författare): Centre of Excellence in Mycotoxicology and Public Health, Department of Bioanalysis, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium

Huybrechts, Inge (författare): Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 150 Cours Albert Thomas, Lyon, France

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2022-08-30
2022
Engelska.
Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 14:17

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BACKGROUND: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox's proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day.RESULTS: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development.CONCLUSIONS: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

epidemiology
Europe
exposure
external assessment
kidney cancer
mycotoxins
prevention
renal cancer
epidemiology
Europe
exposure
external assessment
kidney cancer
mycotoxins
prevention
renal cancer

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Näringslära

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