Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization

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Dam, VeerleJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands,Interuniversity Cardiology Institute of the Netherlands (författare)

Genetically Determined Reproductive Aging and Coronary Heart Disease : A Bidirectional 2-sample Mendelian Randomization

Artikel/kapitelEngelska2022

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2022-03-20
The Endocrine Society,2022
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LIBRIS-ID:oai:DiVA.org:umu-203194
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-203194URI
https://doi.org/10.1210/clinem/dgac171DOI
https://lup.lub.lu.se/record/e3d18d3f-9f96-46cb-92e9-2cfaf4c14900URI

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Språk:engelska
Sammanfattning på:engelska

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Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
coronary heart disease
Mendelian Randomization
reproductive aging
risk factors
coronary heart disease
Mendelian Randomization
reproductive aging
risk factors
aging
coronary artery disease
female
genetics
genome-wide association study
human
male
Mendelian randomization analysis
procedures
single nucleotide polymorphism
Aging
Coronary Disease
Female
Genome-Wide Association Study
Humans
Male
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Biuppslag (personer, institutioner, konferenser, titlar ...)

Onland-Moret, N. CharlotteJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
Burgess, StephenMRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom (författare)
Chirlaque, Maria-DoloresDepartment of Epidemiology, Regional Health Authority, IMIB-Arrixaca, Murcia University, Murcia, Spain (författare)
Peters, Sanne A. EJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; The George Institute for Global Health, Imperial College London, London, United Kingdom (författare)
Schuit, EwoudJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
Tikk, KajaDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium, DKFZ, Heidelberg, Germany (författare)
Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
Oliver-Williams, ClareMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom (författare)
Wood, Angela MMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
Tjønneland, AnneDanish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Dahm, Christina CDepartment of Public Health, Aarhus University, Aarhus, Denmark (författare)
Overvad, KimDepartment of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark (författare)
Boutron-Ruault, Marie-ChristineINSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones, and Women's Health Team, Institut Gustave Roussy, Villejuif, France (författare)
Schulze, Matthias BDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (författare)
Trichopoulou, AntoniaHellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece (författare)
Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy (författare)
Krogh, VittorioEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (författare)
Tumino, RosarioCancer Registry and Histopathology Department, "Civic - M.P. Arezzo" hospital, ASP Ragusa, Ragusa, Italy (författare)
Matullo, GiuseppeDepartment of Medical Sciences, University of Torino, Torino, Italy; Italian Institute for Genomic Medicine–IIGM/HuGeF, Torino, Italy (författare)
Panico, SalvatoreDipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy (författare)
Boer, Jolanda M. ANational Institute for Public Health and the Environment, Bilthoven, Netherlands (författare)
Verschuren, W. M. MoniqueJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands (författare)
Waaseth, MaritDepartment of Pharmacy, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway (författare)
PCrossed D sign©rez, Maria JosCrossed D sign© SánchezEscuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (författare)
Amiano, PilarCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain (författare)
Imaz, LiherCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain (författare)
Moreno-Iribas, ConchiInstituto de Salud Pública de Navarra, IdiSNA, Navarre Institute for Health Research, REDISSEC, Pamplona, Spain (författare)
Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (författare)
Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105 (författare)
Nordendahl, MariaUmeå universitet,Onkologi,Allmänmedicin(Swepub:umu)maacln97 (författare)
Wennberg, Patrik,1972-Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002 (författare)
Key, Timothy JNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (författare)
Riboli, ElioDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
Santiuste, CarmenCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Authority, IMIB-Arrixaca, Murcia, Spain (författare)
Kaaks, RudolfDivision of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany (författare)
Katzke, VerenaDivision of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany (författare)
Langenberg, ClaudiaMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
Wareham, Nicholas JMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom (författare)
Schunkert, HeribertDeutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany (författare)
Erdmann, JeanetteInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany (författare)
Willenborg, ChristinaInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany (författare)
Hengstenberg, ChristianDepartment of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria (författare)
Kleber, Marcus EVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (författare)
Delgado, GracielaVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (författare)
März, WinfriedVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria (författare)
Kanoni, StavroulaWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (författare)
Dedoussis, GeorgeDepartment of Nutrition-Dietetics/Harokopio University, Athens, Greece (författare)
Deloukas, PanosWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Centre for Genomic Health, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia (författare)
Nikpay, MajidRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada (författare)
Mcpherson, RuthRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada (författare)
Scholz, MarkusInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany (författare)
Teren, AndrejLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Heart Center Leipzig, Leipzig, Germany (författare)
Butterworth, Adam SMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (författare)
Van Der Schouw, Yvonne TJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, NetherlandsInteruniversity Cardiology Institute of the Netherlands (creator_code:org_t)

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Ingår i:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society107:7, s. E2952-E29610021-972X1945-7197

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Av författaren/redakt...: Dam, Veerle; Onland-Moret, N. ...; Burgess, Stephen; Chirlaque, Maria ...; Peters, Sanne A. ...; Schuit, Ewoud; visa fler...; Tikk, Kaja; Weiderpass, Elis ...; Oliver-Williams, ...; Wood, Angela M; Tjønneland, Anne; Dahm, Christina ...; Overvad, Kim; Boutron-Ruault, ...; Schulze, Matthia ...; Trichopoulou, An ...; Ferrari, Pietro; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Matullo, Giusepp ...; Panico, Salvator ...; Boer, Jolanda M. ...; Verschuren, W. M ...; Waaseth, Marit; PCrossed D sign© ...; Amiano, Pilar; Imaz, Liher; Moreno-Iribas, C ...; Melander, O.; Harlid, Sophia, ...; Nordendahl, Mari ...; Wennberg, Patrik ...; Key, Timothy J; Riboli, Elio; Santiuste, Carme ...; Kaaks, Rudolf; Katzke, Verena; Langenberg, Clau ...; Wareham, Nichola ...; Schunkert, Herib ...; Erdmann, Jeanett ...; Willenborg, Chri ...; Hengstenberg, Ch ...; Kleber, Marcus E; Delgado, Graciel ...; März, Winfried; Kanoni, Stavroul ...; Dedoussis, Georg ...; Deloukas, Panos; Nikpay, Majid; Mcpherson, Ruth; Scholz, Markus; Teren, Andrej; Butterworth, Ada ...; Van Der Schouw, ...; visa färre...

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