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Prospective association of daily steps with cardiovascular disease : a harmonized meta-analysis

Paluch, Amanda E. (författare)
Department of Kinesiology, Institute for Applied Life Sciences, University of Massachusetts Amherst (A.E.P., S.B.
Bajpai, Shivangi (författare)
Department of Kinesiology, Institute for Applied Life Sciences, University of Massachusetts Amherst (A.E.P., S.B.
Ballin, Marcel (författare)
Umeå universitet,Geriatrik
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Bassett, David R. (författare)
Department of Kinesiology, Recreation, Sport Studies, University of Tennessee, University of Alabama at Birmingham
Buford, Thomas W. (författare)
Departments of Medicine, University of Alabama at Birmingham; Birmingham/Atlanta Geriatric Research, Education, Clinical Center, Birmingham VA Medical Center, AL (T.W.B.)
Carnethon, Mercedes R. (författare)
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Mexico
Chernofsky, Ariel (författare)
Department of Biostatistics, Boston University
Dooley, Erin E. (författare)
Epidemiology (E.E.D.' K.P.G.), University of Alabama at Birmingham
Ekelund, Ulf (författare)
Department of Sport Medicine, Norwegian School of Sport Sciences, Norway; Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Norway
Evenson, Kelly R. (författare)
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill (K.R.E.)
Galuska, Deborah A. (författare)
Division of Nutrition, Physical Activity, Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, United States
Jefferis, Barbara J. (författare)
Department of Primary Care and Population Health, University College London Medical School, United Kingdom (B.J.J.), London, United Kingdom
Kong, Lingsong (författare)
Department of Kinesiology, Institute for Applied Life Sciences, University of Massachusetts Amherst (A.E.P., S.B.
Kraus, William E. (författare)
Duke Molecular Physiology Institute, Durham, United Kingdom; Department of Medicine, Duke University, Durham, United Kingdom
Larson, Martin G. (författare)
Department of Biostatistics, Boston University
Lee, I-Min (författare)
Brigham and Women's Hospital, Harvard Medical School and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States
Matthews, Charles E. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, United States
Newton, Robert L. (författare)
Pennington Biomedical Research Center, Baton Rouge, United States
Nordström, Anna (författare)
Umeå universitet,Avdelningen för hållbar hälsa,Geriatrik,School of Sport Sciences, UiT The Arctic University of Norway, Norway
Nordström, Peter (författare)
Umeå universitet,Geriatrik
Palta, Priya (författare)
Department of Medicine, Columbia University
Patel, Alpa V. (författare)
American Cancer Society, Population Science Department, Atlanta, United States
Pettee Gabriel, Kelley (författare)
Epidemiology (E.E.D.' K.P.G.), University of Alabama at Birmingham
Pieper, Carl F. (författare)
Department of Medicine, Duke University, Durham, United Kingdom
Pompeii, Lisa (författare)
Department of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine, Houston, United States
Rees-Punia, Erika (författare)
American Cancer Society, Population Science Department, Atlanta, United States
Spartano, Nicole L. (författare)
Departments of Endocrinology, Diabetes, Nutrition and Weight Management (N.L.S.), Boston University School of Medicine, MA, United States
Vasan, Ramachandran S. (författare)
Medicine and Epidemiology (R.S.V.), Boston University School of Medicine, MA, United States; Department of Medicine and Epidemiology, Boston University School of Public Health
Whincup, Peter H. (författare)
Population Health Research Institute, St George's' University of London, United Kingdom (P.H.W.), United Kingdom
Yang, Shengping (författare)
Pennington Biomedical Research Center, Baton Rouge, United States
Fulton, Janet E. (författare)
Division of Nutrition, Physical Activity, Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, United States
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Department of Kinesiology, Institute for Applied Life Sciences, University of Massachusetts Amherst (AE.P., S.B. Geriatrik (creator_code:org_t)
2023
2023
Engelska.
Ingår i: Circulation. - 0009-7322 .- 1524-4539. ; 147:2, s. 122-131
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines.METHODS: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance-weighted random effects models.RESULTS: The mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults.CONCLUSIONS: For older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician-patient communication and population health to reduce the risk of CVD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

cardiovascular disease
exercise
public health
risk reduction behavior

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ref (ämneskategori)
art (ämneskategori)

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