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Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk : a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Harewood, Rhea (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Rothwell, Joseph A. (författare)
Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Faculté de Médecine, Université Paris-Saclay, UVSQ, INSERM, Gustave Roussy, Villejuif, France
Bešević, Jelena (författare)
Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Viallon, Vivian (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Achaintre, David (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France; School of Plant Sciences and Food Security, Faculty of Biology, Tel-Aviv University, Tel Aviv-Yafo, Israel
Gicquiau, Audrey (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Rinaldi, Sabina (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Wedekind, Roland (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Prehn, Cornelia (författare)
Metabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany
Adamski, Jerzy (författare)
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, South Africa; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia
Schmidt, Julie A. (författare)
Department of Clinical Medicine, Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Olof Palmes Allé 43-45, Aarhus N, Denmark
Jacobs, Inarie (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Olsen, Anja (författare)
Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; The Department of Public Health, University of Aarhus, Aarhus, Denmark
Severi, Gianluca (författare)
Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Faculté de Médecine, Université Paris-Saclay, UVSQ, INSERM, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti”, University of Florence, Florence, Italy
Kaaks, Rudolf (författare)
German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Katzke, Verena (författare)
German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Prada, Marcela (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany
Masala, Giovanna (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
Agnoli, Claudia (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, Milan, Italy
Panico, Salvatore (författare)
Dipartimento Di Medicina Clinica E Chirurgia Federico Ii University, Naples, Italy
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Via Santena 7, Turin, Italy
Jakszyn, Paula Gabriela (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Castilla, Jesús (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública de Navarra – IdiSNA, Pamplona, Spain
Chirlaque, María-Dolores (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
Atxega, Amaia Aizpurua (författare)
Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Papier, Keren (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Tong, Tammy Y.N. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Summers, Scott A. (författare)
Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, UT, Salt Lake City, United States
Playdon, Mary (författare)
Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, UT, Salt Lake City, United States; Cancer Control and Population Sciences, Huntsman Cancer Institute, UT, Salt Lake City, United States
Cross, Amanda J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Keski-Rahkonen, Pekka (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Chajès, Véronique (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Murphy, Neil (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France
Gunter, Marc J. (författare)
International Agency for Research on Cancer (IARC), 25 Av. Tony Garnier, Lyon, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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International Agency for Research on Cancer (IARC), 25 Av Tony Garnier, Lyon, France Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Faculté de Médecine, Université Paris-Saclay, UVSQ, INSERM, Gustave Roussy, Villejuif, France (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 101
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain.Methods: In a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk.Findings: Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (ORper doubling 0.60, 95% CI 0.47–0.77) and acylakyl-phosphatidylcholine (PC ae) C34:3 (ORper doubling 0.71, 95% CI 0.59–0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer.Interpretation: Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations. Funding: World Cancer Research Fund (reference: 2013/1002); European Commission (FP7: BBMRI-LPC; reference: 313010).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Acylcarnitines
Colorectal cancer
Glycerophospholipids
Lipids
Metabolomics
Sphingolipids

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