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  • Brandsma, JoostClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (författare)

Stratification of asthma by lipidomic profiling of induced sputum supernatant

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-208055
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208055URI
  • https://doi.org/10.1016/j.jaci.2023.02.032DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153575959URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Asthma is a chronic respiratory disease with significant heterogeneity in its clinical presentation and pathobiology. There is need for improved understanding of respiratory lipid metabolism in asthma patients and its relation to observable clinical features.Objective: We performed a comprehensive, prospective, cross-sectional analysis of the lipid composition of induced sputum supernatant obtained from asthma patients with a range of disease severities, as well as from healthy controls.Methods: Induced sputum supernatant was collected from 211 adults with asthma and 41 healthy individuals enrolled onto the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) study. Sputum lipidomes were characterized by semiquantitative shotgun mass spectrometry and clustered using topologic data analysis to identify lipid phenotypes.Results: Shotgun lipidomics of induced sputum supernatant revealed a spectrum of 9 molecular phenotypes, highlighting not just significant differences between the sputum lipidomes of asthma patients and healthy controls, but also within the asthma patient population. Matching clinical, pathobiologic, proteomic, and transcriptomic data helped inform the underlying disease processes. Sputum lipid phenotypes with higher levels of nonendogenous, cell-derived lipids were associated with significantly worse asthma severity, worse lung function, and elevated granulocyte counts.Conclusion: We propose a novel mechanism of increased lipid loading in the epithelial lining fluid of asthma patients resulting from the secretion of extracellular vesicles by granulocytic inflammatory cells, which could reduce the ability of pulmonary surfactant to lower surface tension in asthmatic small airways, as well as compromise its role as an immune regulator.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Schofield, James P.R.National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom; Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom (författare)
  • Yang, XianData Science Institute, Imperial College, London, United Kingdom (författare)
  • Strazzeri, FabioMathematical Sciences, University of Southampton, Southampton, United Kingdom (författare)
  • Barber, ClairNational Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (författare)
  • Goss, Victoria M.Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (författare)
  • Koster, GrielofClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (författare)
  • Bakke, Per S.Department of Clinical Science, University of Bergen, Bergen, Norway (författare)
  • Caruso, MassimoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy (författare)
  • Chanez, PascalDepartment of Respiratory Diseases, Aix-Marseille University, Marseille, France (författare)
  • Dahlén, Sven-ErikInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (författare)
  • Fowler, Stephen J.Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (författare)
  • Horváth, IldikóDepartment of Pulmonology, Semmelweis University, Budapest, Hungary (författare)
  • Krug, NorbertFraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany (författare)
  • Montuschi, PaoloDepartment of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy; National Heart and Lung Institute, Imperial College, London, United Kingdom (författare)
  • Sanak, MarekDepartment of Medicine, Jagiellonian University, Krakow, Poland (författare)
  • Sandström, Thomas,1957-Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)thsa0001 (författare)
  • Shaw, Dominick E.National Institute for Health Research Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom (författare)
  • Chung, Kian FanNational Heart and Lung Institute, Imperial College, London, United Kingdom (författare)
  • Singer, FlorianDivision of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Paediatrics and Adolescent Medicine, Division of Paediatric Pulmonology and Allergology, Medical University of Graz, Graz, Austria (författare)
  • Fleming, Louise J.National Heart and Lung Institute, Imperial College, London, United Kingdom (författare)
  • Adcock, Ian M.National Heart and Lung Institute, Imperial College, London, United Kingdom (författare)
  • Pandis, IoannisData Science Institute, Imperial College, London, United Kingdom (författare)
  • Bansal, Aruna T.Acclarogen Ltd, St John's Innovation Centre, Cambridge, United Kingdom (författare)
  • Corfield, JulieAreteva Ltd, Nottingham, United Kingdom (författare)
  • Sousa, Ana R.Respiratory Therapy Unit, GlaxoSmithKline, London, United Kingdom (författare)
  • Sterk, Peter J.Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands (författare)
  • Sánchez-García, Rubén J.Mathematical Sciences, University of Southampton, Southampton, United Kingdom (författare)
  • Skipp, Paul J.Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom (författare)
  • Postle, Anthony D.Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (författare)
  • Djukanović, RatkoClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (författare)
  • Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United KingdomNational Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom; Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Allergy and Clinical Immunology: Elsevier152:1, s. 117-1250091-67491097-6825

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