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A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

Zhou, Sirui (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada
Butler-Laporte, Guillaume (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada
Nakanishi, Tomoko (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada; Kyoto-McGill International Collaborative School in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Research Fellow, Japan Society for the Promotion of Science, Tokyo, Japan
visa fler...
Morrison, David R. (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Afilalo, Jonathan (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Div Cardiol, Dept Med, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Department of Medicine, Division of Cardiology, McGill University, QC, Montréal, Canada
Afilalo, Marc (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Dept Emergency Med, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Emergency Medicine, Jewish General Hospital, McGill University, QC, Montréal, Canada
Laurent, Laetitia (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Pietzner, Maik (författare)
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Kerrison, Nicola (författare)
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Zhao, Kaiqiong (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada
Brunet-Ratnasingham, Elsa (författare)
Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.;Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada; Department of Microbiology, Infectiology and Immunology, Université de Montréal, QC, Montréal, Canada
Henry, Danielle (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Kimchi, Nofar (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Afrasiabi, Zaman (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Rezk, Nardin (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Bouab, Meriem (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Petitjean, Louis (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Guzman, Charlotte (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Xue, Xiaoqing (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Tselios, Chris (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Vulesevic, Branka (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Adeleye, Olumide (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Abdullah, Tala (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Almamlouk, Noor (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Chen, Yiheng (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada
Chassé, Michaël (författare)
Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada
Durand, Madeleine (författare)
Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada
Paterson, Clare (författare)
SomaLog Inc, Boulder, CO USA.,SomaLogic, Inc., CO, Boulder, United States
Normark, Johan (författare)
Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Immunologi/immunkemi,Wallenberg Center for Molecular Medicine, Umeå Universitet, Sverige
Frithiof, Robert (författare)
Uppsala universitet,Anestesiologi och intensivvård,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Lipcsey, Miklós (författare)
Uppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Hedenstierna Laboratory, CIRRUS, Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Hultström, Michael, 1978- (författare)
Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård,Anaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Greenwood, Celia M. T. (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Gerald Bronfman Dept Oncol, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Gerald Bronfman Department of Oncology, McGill University, QC, Montréal, Canada
Zeberg, Hugo (författare)
Karolinska Institutet,Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Langenberg, Claudia (författare)
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.;Charite Univ Med Berlin, Berlin Inst Hlth, Computat Med, Berlin, Germany.,MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Computational Medicine, Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany
Thysell, Elin (författare)
Umeå universitet,Patologi
Pollak, Michael (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Departments of Medicine and Oncology, McGill University, QC, Montréal, Canada
Mooser, Vincent (författare)
McGill Univ, Dept Human Genet, Montreal, PQ, Canada.,Department of Human Genetics, McGill University, QC, Montréal, Canada
Forgetta, Vincenzo (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada
Kaufmann, Daniel E. (författare)
Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.;Univ Montreal, Dept Med, Montreal, PQ, Canada.,Research Centre of the Centre Hospitalier de l’Université de Montréal, QC, Montréal, Canada; Department of Medicine, Université de Montréal, QC, Montréal, Canada
Richards, J. Brent (författare)
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kings Coll London, Dept Twin Res, London, England.,Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada; Department of Twin Research, King’s College London, London, United Kingdom
visa färre...
McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada. Lady Davis Institute, Jewish General Hospital, McGill University, QC, Montréal, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, QC, Montréal, Canada (creator_code:org_t)
2021-02-25
2021
Engelska.
Ingår i: Nature Medicine. - : Springer Nature. - 1078-8956 .- 1546-170X. ; 27:4, s. 659-667
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 × 10−8), hospitalization (OR = 0.61, P = 8 × 10−8) and susceptibility (OR = 0.78, P = 8 × 10−6). Measuring OAS1 levels in 504 individuals, we found that higher plasma OAS1 levels in a non-infectious state were associated with reduced COVID-19 susceptibility and severity. Further analyses suggested that a Neanderthal isoform of OAS1 in individuals of European ancestry affords this protection. Thus, evidence from MR and a case–control study support a protective role for OAS1 in COVID-19 adverse outcomes. Available pharmacological agents that increase OAS1 levels could be prioritized for drug development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

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