Genome-wide interaction analysis of folate for colorectal cancer risk

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Bouras, EmmanouilDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece (författare)

Genome-wide interaction analysis of folate for colorectal cancer risk

Artikel/kapitelEngelska2023

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Elsevier,2023
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LIBRIS-ID:oai:DiVA.org:umu-214758
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214758URI
https://doi.org/10.1016/j.ajcnut.2023.08.010DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:155073743URI

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Background: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC.Objectives: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk.Methods: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO).Results: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate.Conclusions: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
colorectal cancer
CRC
European
folate
folic acid
genome-wide
GWIS
interaction
SYN2
synapsin
TIMP4
tissue inhibitor of metalloproteinase 4

Biuppslag (personer, institutioner, konferenser, titlar ...)

Kim, Andre E.Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Lin, YiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Morrison, JohnDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Du, MengmengDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, New York, United States (författare)
Albanes, DemetriusDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Barry, Elizabeth L.Department of Epidemiology, Geisel School of Medicine at Dartmouth, NH, Hanover, United States (författare)
Baurley, James W.Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States (författare)
Berndt, Sonja I.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States (författare)
Bien, Stephanie A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Bishop, Timothy D.Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom (författare)
Brenner, HermannDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Budiarto, ArifBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia (författare)
Burnett-Hartman, AndreaInstitute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States (författare)
Campbell, Peter T.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States (författare)
Carreras-Torres, RobertUnit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain (författare)
Casey, GrahamCenter for Public Health Genomics, University of Virginia, VA, Charlottesville, United States (författare)
Cenggoro, Tjeng WawanBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia (författare)
Chan, Andrew T.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
Chang-Claude, JennyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany (författare)
Conti, David V.Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Cotterchio, MichelleOntario Health (Cancer Care Ontario), ON, Toronto, Canada (författare)
Devall, MatthewCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States; Department of Public Health Sciences, Center for Public Health Genomics, VA, Charlottesville, United States (författare)
Diez-Obrero, VirginiaUnit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain (författare)
Dimou, NikiNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Drew, David A.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States (författare)
Figueiredo, Jane C.Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States (författare)
Giles, Graham G.Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia (författare)
Gruber, Stephen B.Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States (författare)
Gunter, Marc J.Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Harrison, Tabitha A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Hidaka, AkihisaPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Hoffmeister, MichaelDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
Huyghe, Jeroen R.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Joshi, Amit D.Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States (författare)
Kawaguchi, Eric S.Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, Los Angeles, United States (författare)
Keku, Temitope O.Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States (författare)
Kundaje, AnshulDepartment of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States (författare)
Le Marchand, LoicUniversity of Hawaii Cancer Center, HI, Honolulu, United States (författare)
Lewinger, Juan PabloDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Li, LiDepartment of Family Medicine, University of Virginia, VA, Charlottesville, United States (författare)
Lynch, Brigid M.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia (författare)
Mahesworo, BharunoBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia (författare)
Männistö, SatuDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland (författare)
Moreno, VictorUnit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain (författare)
Murphy, NeilNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Newcomb, Polly A.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States (författare)
Obón-Santacana, MireiaUnit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain (författare)
Ose, JenniferHuntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Palmer, Julie R.Slone Epidemiology Center at Boston University, MA, Boston, United States (författare)
Papadimitriou, NikosNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
Pardamean, BensBioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia (författare)
Pellatt, Andrew J.Department of Cancer Medicine, MD Anderson Cancer Center, TX, Houston, United States (författare)
Peoples, Anita R.Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Platz, Elizabeth A.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
Potter, John D.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand (författare)
Qi, LihongDepartment of Public Health Sciences, University of California Davis, CA, Davis, United States (författare)
Qu, ConghuiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Rennert, GadDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel (författare)
Ruiz-Narvaez, EdwardDepartment of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States (författare)
Sakoda, Lori C.Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States (författare)
Schmit, Stephanie L.Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States (författare)
Shcherbina, AnnaDepartment of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States (författare)
Stern, Mariana C.Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Su, Yu-RuPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States (författare)
Tangen, Catherine M.SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States (författare)
Thomas, Duncan C.Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Tian, YuDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China (författare)
Um, Caroline Y.Department of Population Science, American Cancer Society, GA, Atlanta, United States (författare)
van Duijnhoven, Franzel JB.Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands (författare)
van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (författare)
Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States (författare)
Wang, JunDepartment of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
White, EmilyPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States (författare)
Wolk, AlicjaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
Woods, Michael O.Memorial University of Newfoundland, Discipline of Genetics, St John's, Canada (författare)
Ulrich, Cornelia M.Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States (författare)
Hsu, LiPublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States (författare)
Gauderman, W JamesDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (författare)
Peters, UlrikePublic Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States (författare)
Tsilidis, Konstantinos K.Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, GreeceDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States (creator_code:org_t)

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Ingår i:American Journal of Clinical Nutrition: Elsevier118:5, s. 881-8910002-91651938-3207

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Av författaren/redakt...: Bouras, Emmanoui ...; Kim, Andre E.; Lin, Yi; Morrison, John; Du, Mengmeng; Albanes, Demetri ...; visa fler...; Barry, Elizabeth ...; Baurley, James W ...; Berndt, Sonja I.; Bien, Stephanie ...; Bishop, Timothy ...; Brenner, Hermann; Budiarto, Arif; Burnett-Hartman, ...; Campbell, Peter ...; Carreras-Torres, ...; Casey, Graham; Cenggoro, Tjeng ...; Chan, Andrew T.; Chang-Claude, Je ...; Conti, David V.; Cotterchio, Mich ...; Devall, Matthew; Diez-Obrero, Vir ...; Dimou, Niki; Drew, David A.; Figueiredo, Jane ...; Giles, Graham G.; Gruber, Stephen ...; Gunter, Marc J.; Harrison, Tabith ...; Hidaka, Akihisa; Hoffmeister, Mic ...; Huyghe, Jeroen R ...; Joshi, Amit D.; Kawaguchi, Eric ...; Keku, Temitope O ...; Kundaje, Anshul; Le Marchand, Loi ...; Lewinger, Juan P ...; Li, Li; Lynch, Brigid M.; Mahesworo, Bharu ...; Männistö, Satu; Moreno, Victor; Murphy, Neil; Newcomb, Polly A ...; Obón-Santacana, ...; Ose, Jennifer; Palmer, Julie R.; Papadimitriou, N ...; Pardamean, Bens; Pellatt, Andrew ...; Peoples, Anita R ...; Platz, Elizabeth ...; Potter, John D.; Qi, Lihong; Qu, Conghui; Rennert, Gad; Ruiz-Narvaez, Ed ...; Sakoda, Lori C.; Schmit, Stephani ...; Shcherbina, Anna; Stern, Mariana C ...; Su, Yu-Ru; Tangen, Catherin ...; Thomas, Duncan C ...; Tian, Yu; Um, Caroline Y.; van Duijnhoven, ...; van Guelpen, Bet ...; Visvanathan, Kal ...; Wang, Jun; White, Emily; Wolk, Alicja; Woods, Michael O ...; Ulrich, Cornelia ...; Hsu, Li; Gauderman, W Jam ...; Peters, Ulrike; Tsilidis, Konsta ...; visa färre...

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