Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

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Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

Yasinska, Valentyna (författare): Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden

Gómez, Cristina (författare): Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Kolmert, Johan (författare): Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

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Ericsson, Magnus (författare): Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden; Laboratoire AntiDopage Français, Université Paris-Saclay, Châtenay-Malabry, France

Pohanka, Anton (författare): Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden

James, Anna (författare): Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Andersson, Lars I. (författare): Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden

Sparreman-Mikus, Maria (författare): Karolinska Institutet

Sousa, Ana R. (författare): Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom

Riley, John H. (författare): Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom

Bates, Stewart (författare): Respiratory and Speciality Group, GSK, Clinical Sciences, Stockley Park, United Kingdom

Bakke, Per S. (författare): Institute of Clinical Science, University of Bergen, Bergen, Norway

Kermani, Nazanin Zounemat (författare): National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom

Caruso, Massimo (författare): Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

Chanez, Pascal (författare): Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France

Fowler, Stephen J. (författare): Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

Geiser, Thomas (författare): Department of Pulmonary Medicine, University Hospital, University of Bern, Bern, Switzerland

Howarth, Peter H. (författare): Faculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom

Horváth, Ildikó (författare): Department of Public Health, Semmelweis University, Budapest, Hungary; National Koranyi Institute for Pulmonology, Budapest, Hungary

Krug, Norbert (författare): Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Montuschi, Paolo (författare): National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom; Department of Pharmacology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy

Sanak, Marek (författare): Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland

Behndig, Annelie F., 1963- (författare): Umeå universitet,Institutionen för folkhälsa och klinisk medicin

Shaw, Dominick E. (författare): Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom

Knowles, Richard G. (författare): Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, United Kingdom

Dahlén, Barbro (författare): Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden

van der Zee, Anke-Hilse Maitland (författare): Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

Sterk, Peter J. (författare): Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

Djukanovic, Ratko (författare): Faculty of Medicine, Southampton University, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Center, University Hospital Southampton, Southampton, United Kingdom

Adcock, Ian M. (författare): National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom

Chung, Kian Fan (författare): National Heart and Lung Institute and Data Science Institute, Imperial College London, London, United Kingdom

Wheelock, Craig E. (författare): Karolinska Institutet

Dahlén, Sven-Erik (författare): Clinical Lung and Allergy Research, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden; The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Jonsson, Eva Wikström (författare): Karolinska Institutet

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European Respiratory Society, 2023
2023
Engelska.
Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 9:5

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Rationale: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure.Methods: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry. Data were compared to that of mild-to-moderate asthmatics (MMA, n=70) and healthy subjects (HC, n=98) from the same study.Measurements and main results: The concentrations of urinary endogenous steroid metabolites were substantially lower in SA than in MMA or HC. These differences were more pronounced in SA patients with detectable urinary OCS metabolites. Their dehydroepiandrosterone sulfate (DHEA-S) concentrations were <5% of those in HC, and cortisol concentrations were below the detection limit in 75% of females and 82% of males. The concentrations of EAAS in OCS-positive patients, as well as patients on high-dose ICS only, were more suppressed in females than males (p<0.05). Low levels of DHEA were associated with features of more severe disease and were more prevalent in females (p<0.05). The association between low EAAS and corticosteroid treatment was replicated in 289 of the SA patients at follow-up after 12–18 months.Conclusion: The pronounced suppression of endogenous anabolic androgens in females might contribute to sex differences regarding the prevalence of severe asthma.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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Av lärosätet: Umeå universitet; Karolinska Institutet

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Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

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