Long-term side effects after treatment of Hodgkin's lymphoma

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Andersson, Anne,1966-Umeå universitet,Onkologi (författare)

Long-term side effects after treatment of Hodgkin's lymphoma

BokEngelska2011

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Umeå :Umeå universitet,2011
46 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-43287
ISBN:9789174591880
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-43287URI

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Språk:engelska
Sammanfattning på:engelska

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Umeå University medical dissertations,0346-6612 ;1416

Anmärkningar

Background Long-term side effects associated with the treatment of Hodgkin’s lymphoma (HL) have frequently been reported during the last decades. Studies have shown increased mortality in HL survivors. Following Hodgkin’s lymphoma, second malignancies (SM) and cardiovascular disease (CVD) are the most common causes of death in individuals treated for HL. This study investigates the incidence of side effects such as SM, CVD and infections in a cohort diagnosed with HL in Sweden between 1965 and 1995. In addition, this study identifies covariate risk factors for late side effects in order to develop strategies that prevent morbidity and mortality in HL survivors. Methods Using the Swedish Cancer Registry (SCR) at the National Board of Health and Welfare and the Multi-Generation Registry at Statistics (MGR) Sweden, we identified 6946 individuals diagnosed with HL between the years 1965 and 1995, and their first degree relatives (FDR) (n=17 858). In addition we identified the malignancies and inpatient care for CVD and infections for the HL cohort and their FDR. The standard incidence ratio (SIR) was calculated for the risk of SM, CVD and infections. For SM and CVD the risk also was stratified and calculated for family history of disease. The Swedish Hodgkin Intervention and Prevention study (SHIP), a prospective study, invited 702 individuals treated for HL at the age of 45 years or younger and who were treated in the region of Skåne, Uppsala or Umeå. The participants completed a questionnaire and were invited to an out-patient visit to an oncologist with clinical examination and blood tests. Any pathological findings were referred for further investigation. Results An increased risk for SM in HL long-term survivors was observed and seems to increase with the number of FDRs with cancer. There was also an increased risk for inpatient care due to congestive heart failure (CHF) and coronary artery disease (CAD). A family history of CHF and CAD further increased the risk for these diseases. The risk for inpatient care due to infections was increased and remained increased after 20 years or longer. The risk for infections was associated with splenectomy and hypothyroidism. Radiotherapy was an independent risk factor for cardiovascular disease in the cohort of the prospective study. ConclusionLong-term survivors from HL have an increased risk for developing late side effects such as SM, CVD and infections. Since many HL patients are young and the cure rate from the disease is high, it is of great importance to offer focused surveillance programs to selected individuals who are at high risk, e.g. individuals who received radiotherapy as part of their treatment and who have other known risk factors for cardiovascular disease such as hypertension, hypercholesterolemia, family history and smoking.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Hodgkin
survivorship
long-term side effects
cardiovascular disease
second malignancy
infections
prevention
Oncology
Onkologi
onkologi
Oncology

Biuppslag (personer, institutioner, konferenser, titlar ...)

Melin, Beatrice,Adj professorUmeå universitet,Onkologi(Swepub:umu)bema0010 (preses)
Näslund, Ulf,Adj professorUmeå universitet,Medicin(Swepub:umu)ulna0002 (preses)
Enblad, Gunilla,Adj professorUppsala universitet (preses)
Holte, Harald,MD, PhDDepartment of Oncology, Division of Cancer Medicine and Surgery, Oslo university (opponent)
Umeå universitetOnkologi (creator_code:org_t)

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Av författaren/redakt...: Andersson, Anne, ...; Melin, Beatrice, ...; Näslund, Ulf, Ad ...; Enblad, Gunilla, ...; Holte, Harald, M ...

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Delar i serien: Umeå University ...

Av lärosätet: Umeå universitet

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