Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

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Kirchhoff, TomasMem Sloan Kettering Cancer Centre, USA (author)

Breast cancer risk and 6q22.33 : combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Article/chapterEnglish2012

Publisher, publication year, extent ...

2012-06-29
Public library of science,2012
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-60144
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60144URI
https://doi.org/10.1371/journal.pone.0035706DOI
https://lup.lub.lu.se/record/3001546URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:124891753URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79692URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
genome-wide association
susceptibility loci
variants
alleles
FGFR2
gene
MEDICINE

Added entries (persons, corporate bodies, meetings, titles ...)

Gaudet, Mia MMem Sloan Kettering Cancer Centre, USA,University of Medical Centre Utrecht, Netherlands (author)
Antoniou, Antonis CUniversity of Cambridge, England,University of Pisa, Italy Pisa University Hospital, Italy,Yorkshire Regional Genet Serv, England (author)
McGuffog, LesleyUniversity of Cambridge, England (author)
Humphreys, Manjeet KUniversity of Cambridge, England (author)
Dunning, Alison MUniversity of Cambridge, England (author)
Bojesen, Stig EUniversity of Copenhagen, Denmark (author)
Nordestgaard, Børge GUniversity of Copenhagen, Denmark University of Copenhagen, Denmark (author)
Flyger, HenrikUniversity of Copenhagen, Denmark (author)
Kang, DaeheeSeoul National University, South Korea National Cancer Centre, South Korea University of Ulsan, South Korea (author)
Yoo, Keun-YoungSeoul National University, South Korea National Cancer Centre, South Korea University of Ulsan, South Korea (author)
Noh, Dong-YoungSeoul National University, South Korea National Cancer Centre, South Korea University of Ulsan, South Korea (author)
Ahn, Sei-HyunSeoul National University, South Korea National Cancer Centre, South Korea University of Ulsan, South Korea (author)
Dork, ThiloHannover Medical Sch, Germany Hannover Medical Sch, Germany (author)
Schürmann, PeterHannover Medical Sch, Germany Hannover Medical Sch, Germany (author)
Karstens, Johann HHannover Medical Sch, Germany Hannover Medical Sch, Germany,Queensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia (author)
Hillemanns, PeterHannover Medical Sch, Germany Hannover Medical Sch, Germany (author)
Couch, Fergus JMayo Clin, MN USA Mayo Clin, MN USA (author)
Olson, JanetMayo Clin, MN USA (author)
Vachon, CelineMayo Clin, MN USA (author)
Wang, XianshuMayo Clin, MN USA (author)
Cox, AngelaUniversity of Sheffield, England (author)
Brock, IanUniversity of Sheffield, England (author)
Elliott, GraemeUniversity of Sheffield, England (author)
Reed, Malcolm W RUniversity of Sheffield, England (author)
Burwinkel, BarbaraGerman Cancer Research Centre, Germany,Queensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia,Netherlands Cancer Institute, Netherlands,University Hospital Maastricht, Netherlands (author)
Meindl, AlfonsTechnical University of Munich, Germany,Leiden University, Netherlands (author)
Brauch, HiltrudDr Margarete Fischer Bosch Institute Clin Pharmacol, Germany University of Tubingen, Germany University of Tubingen, Germany (author)
Hamann, UteDeutsch Krebsforschungszentrum, Germany (author)
Ko, Yon-DschunEvangel Kliniken Bonn gGmbH, Germany (author)
Broeks, AnnegienNetherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands (author)
Schmidt, Marjanka KNetherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands (author)
Van 't Veer, Laura JNetherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands (author)
Braaf, Linde MNetherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands Netherlands Cancer Institute, Netherlands (author)
Johnson, NicholaInstitute Cancer Research, England (author)
Fletcher, OliviaInstitute Cancer Research, England (author)
Gibson, LornaLondon School Hyg and Trop Med, England (author)
Peto, JulianLondon School Hyg and Trop Med, England,Vrije University, Netherlands (author)
Turnbull, ClareInstitute Cancer Research, England,University of Cambridge, England (author)
Seal, SheilaKarolinska Institutet,Institute Cancer Research, England (author)
Renwick, AnthonyInstitute Cancer Research, England (author)
Rahman, NazneenInstitute Cancer Research, England (author)
Wu, Pei-EiAcademic Sinica, Taiwan (author)
Yu, Jyh-CherngTri Serv Gen Hospital, Taiwan (author)
Hsiung, Chia-NiAcademic Sinica, Taiwan (author)
Shen, Chen-YangAcademic Sinica, Taiwan (author)
Southey, Melissa CUniversity of Melbourne, Australia Cancer Council, Australia University of Melbourne, Australia (author)
Hopper, John LUniversity of Melbourne, Australia (author)
Hammet, FleurUniversity of Melbourne, Australia (author)
Van Dorpe, ThijsKatholieke University of Leuven, Belgium (author)
Dieudonne, Anne-SophieKatholieke University of Leuven, Belgium (author)
Hatse, SigridKatholieke University of Leuven, Belgium (author)
Lambrechts, DietherVesalius Research Centre, Belgium (author)
Andrulis, Irene LKarolinska Institutet,Cancer Care Ontario, Canada Mt Sinai Hospital, Canada University of Toronto, Canada (author)
Bogdanova, NataliaNN Alexandrov Research Institute Oncology and Medical Radiol, Byelarus (author)
Antonenkova, NataliaNN Alexandrov Research Institute Oncology and Medical Radiol, Byelarus (author)
Rogov, Juri INN Alexandrov Research Institute Oncology and Medical Radiol, Byelarus (author)
Prokofieva, DariaRussian Academic Science, Russia,University of Cambridge, England University of Cambridge, England (author)
Bermisheva, MarinaRussian Academic Science, Russia (author)
Khusnutdinova, ElzaRussian Academic Science, Russia (author)
van Asperen, Christi JLeiden University, Netherlands (author)
Tollenaar, Robert A E MUniversity of Eastern Finland, Finland Kuopio University Hospital, Finland (author)
Hooning, Maartje JErasmus MC, Netherlands (author)
Devilee, PeterLeiden University, Netherlands (author)
Margolin, SaraKarolinska Institute, Sweden Karolinska University, Sweden (author)
Lindblom, AnnikaKarolinska Institute, Sweden (author)
Milne, Roger LSpanish National Cancer Centre, Spain (author)
Arias, José IgnacioMonte Naranco Hospital, Spain (author)
Zamora, M PilarLa Paz University Hospital, Spain (author)
Benítez, JavierSpanish National Cancer Centre, Spain Centre Invest Biomed Red Enfermedades Rares, Spain (author)
Severi, GianlucaCancer Council, Australia University of Melbourne, Australia (author)
Baglietto, LauraCancer Council, Australia University of Melbourne, Australia (author)
Giles, Graham GCancer Council, Australia University of Melbourne, Australia (author)
Spurdle, Amanda B (author)
Beesley, JonathanQueensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia (author)
Chen, XiaoqingQueensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia (author)
Holland, Helene (author)
Healey, SueQueensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia (author)
Wang-Gohrke, ShanUniversity of Ulm, Germany (author)
Chang-Claude, JennyGerman Cancer Research Centre DFKZ, Germany (author)
Mannermaa, Arto (author)
Kosma, Veli-MattiUniversity of Eastern Finland, Finland Kuopio University Hospital, Finland (author)
Kauppinen, JaanaUniversity of Eastern Finland, Finland Kuopio University Hospital, Finland (author)
Kataja, VesaVaasa Central Hospital, Finland Kuopio University Hospital, Finland (author)
Agnarsson, Bjarni ALandspitali University Hospital, Iceland University of Iceland, Iceland (author)
Caligo, Maria A (author)
Godwin, Andrew KFox Chase Cancer Centre, PA 19111 USA (author)
Nevanlinna, HeliUniversity of Helsinki, Finland (author)
Heikkinen, TuomasUniversity of Helsinki, Finland (author)
Fredericksen, ZacharyMayo Clin, MN USA (author)
Lindor, NoralaneMayo Clin, MN USA (author)
Nathanson, Katherine LUniversity of Penn, PA 19104 USA University of Penn, PA 19104 USA (author)
Domchek, Susan MUniversity of Penn, PA 19104 USA University of Penn, PA 19104 USA (author)
Loman, NiklasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Lund Hospital, Sweden(Swepub:lu)onk-nlo (author)
Karlsson, PerSahlgrens University Hospital, Sweden (author)
Stenmark Askmalm, MarieÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)marst93 (author)
Melin, BeatriceUmeå universitet,Onkologi,Umeå University, Sweden(Swepub:umu)bema0010 (author)
von Wachenfeldt, AnnaKarolinska University Hospital, Sweden (author)
Hogervorst, Frans B L (author)
Verheus, MartijnNetherlands Cancer Institute, Netherlands (author)
Rookus, Matti ANetherlands Cancer Institute, Netherlands (author)
Seynaeve, CarolineErasmus MC, Netherlands (author)
Oldenburg, Rogier AErasmus MC, Netherlands (author)
Ligtenberg, Marjolijn JRadboud University of Nijmegen, Netherlands (author)
Ausems, Margreet G E M (author)
Aalfs, Cora MAmsterdam Medical Centre, Netherlands (author)
Gille, Hans J P (author)
Wijnen, Juul TVrije University, Netherlands (author)
Gómez García, Encarna B (author)
Peock, SusanUniversity of Cambridge, England (author)
Cook, MargaretUniversity of Cambridge, England (author)
Oliver, Clare T (author)
Frost, DebraUniversity of Cambridge, England (author)
Luccarini, CraigUniversity of Cambridge, England (author)
Pichert, GabriellaGuys and St Thomas NHS Fdn Trust, England (author)
Davidson, RosemarieYorkhill Hospital, Scotland (author)
Chu, Carol (author)
Eccles, DianaPrincess Anne Hospital, England (author)
Ong, Kai-RenBirmingham Womens Hospital Healthcare NHS Trust, England (author)
Cook, JackieSheffield Childrens Hospital, England (author)
Douglas, FionaNewcastle Tyne Hospital NHS Trust, England,University of Cambridge, England University of Cambridge, England (author)
Hodgson, ShirleyUniversity of London, England (author)
Evans, D GarethCentral Manchester University Hospital National Health Serv NHS Fdn, England (author)
Eeles, RosalindInstitute Cancer Research, England Royal Marsden NHS Fdn Trust, England (author)
Gold, BertNCI, MD USA (author)
Pharoah, Paul D P (author)
Offit, KennethMem Sloan Kettering Cancer Centre, NY 10021 USA (author)
Chenevix-Trench, GeorgiaQueensland Institute Medical Research, Australia Peter MacCallum Cancer Centre, Australia (author)
Easton, Douglas F (author)
Mem Sloan Kettering Cancer Centre, USAUniversity of Medical Centre Utrecht, Netherlands (creator_code:org_t)

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By the author/editor: Kirchhoff, Tomas; Gaudet, Mia M; Antoniou, Antoni ...; McGuffog, Lesley; Humphreys, Manje ...; Dunning, Alison ...; show more...; Bojesen, Stig E; Nordestgaard, Bø ...; Flyger, Henrik; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Dork, Thilo; Schürmann, Peter; Karstens, Johann ...; Hillemanns, Pete ...; Couch, Fergus J; Olson, Janet; Vachon, Celine; Wang, Xianshu; Cox, Angela; Brock, Ian; Elliott, Graeme; Reed, Malcolm W ...; Burwinkel, Barba ...; Meindl, Alfons; Brauch, Hiltrud; Hamann, Ute; Ko, Yon-Dschun; Broeks, Annegien; Schmidt, Marjank ...; Van 't Veer, Lau ...; Braaf, Linde M; Johnson, Nichola; Fletcher, Olivia; Gibson, Lorna; Peto, Julian; Turnbull, Clare; Seal, Sheila; Renwick, Anthony; Rahman, Nazneen; Wu, Pei-Ei; Yu, Jyh-Cherng; Hsiung, Chia-Ni; Shen, Chen-Yang; Southey, Melissa ...; Hopper, John L; Hammet, Fleur; Van Dorpe, Thijs; Dieudonne, Anne- ...; Hatse, Sigrid; Lambrechts, Diet ...; Andrulis, Irene ...; Bogdanova, Natal ...; Antonenkova, Nat ...; Rogov, Juri I; Prokofieva, Dari ...; Bermisheva, Mari ...; Khusnutdinova, E ...; van Asperen, Chr ...; Tollenaar, Rober ...; Hooning, Maartje ...; Devilee, Peter; Margolin, Sara; Lindblom, Annika; Milne, Roger L; Arias, José Igna ...; Zamora, M Pilar; Benítez, Javier; Severi, Gianluca; Baglietto, Laura; Giles, Graham G; Spurdle, Amanda ...; Beesley, Jonatha ...; Chen, Xiaoqing; Holland, Helene; Healey, Sue; Wang-Gohrke, Sha ...; Chang-Claude, Je ...; Mannermaa, Arto; Kosma, Veli-Matt ...; Kauppinen, Jaana; Kataja, Vesa; Agnarsson, Bjarn ...; Caligo, Maria A; Godwin, Andrew K; Nevanlinna, Heli; Heikkinen, Tuoma ...; Fredericksen, Za ...; Lindor, Noralane; Nathanson, Kathe ...; Domchek, Susan M; Loman, Niklas; Karlsson, Per; Stenmark Askmalm ...; Melin, Beatrice; von Wachenfeldt, ...; Hogervorst, Fran ...; Verheus, Martijn; Rookus, Matti A; Seynaeve, Caroli ...; Oldenburg, Rogie ...; Ligtenberg, Marj ...; Ausems, Margreet ...; Aalfs, Cora M; Gille, Hans J P; Wijnen, Juul T; Gómez García, En ...; Peock, Susan; Cook, Margaret; Oliver, Clare T; Frost, Debra; Luccarini, Craig; Pichert, Gabriel ...; Davidson, Rosema ...; Chu, Carol; Eccles, Diana; Ong, Kai-Ren; Cook, Jackie; Douglas, Fiona; Hodgson, Shirley; Evans, D Gareth; Eeles, Rosalind; Gold, Bert; Pharoah, Paul D ...; Offit, Kenneth; Chenevix-Trench, ...; Easton, Douglas ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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