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Genetic Risk of Pro...
Genetic Risk of Progression to Type 2 Diabetes and Response to Intensive Lifestyle or Metformin in Prediabetic Women With and Without a History of Gestational Diabetes Mellitus
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- Sullivan, Shannon D. (författare)
- MedStar Washington Hospital Center,Colorado School of Public Health
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- Jablonski, Kathleen A. (författare)
- George Washington University
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- Florez, Jose C. (författare)
- Harvard Medical School,Broad Institute,Massachusetts General Hospital
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Dabelea, Dana (författare)
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- Franks, Paul W. (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Medicin,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,Skåne University Hospital
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- Dagogo-Jack, Sam (författare)
- University of Tennessee
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- Kim, Catherine (författare)
- University of Michigan
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- Knowler, William C. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Christophi, Costas A. (författare)
- George Washington University
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- Ratner, Robert (författare)
- American Diabetes Association
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(creator_code:org_t)
- 2014-03-08
- 2014
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 37:4, s. 909-911
- Relaterad länk:
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https://care.diabete...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- OBJECTIVE The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS We asked if genetic variability could account for these differences by comparing beta-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS beta-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to beta-cell dysfunction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sullivan, Shanno ...
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Jablonski, Kathl ...
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Florez, Jose C.
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Dabelea, Dana
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Franks, Paul W.
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Dagogo-Jack, Sam
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visa fler...
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Kim, Catherine
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Knowler, William ...
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Christophi, Cost ...
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Ratner, Robert
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Umeå universitet
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Lunds universitet