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Interim analysis of...
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Pettersson, D.Karolinska Institutet
(författare)
Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-02-12
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Oxford University Press (OUP),2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-125800
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125800URI
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https://doi.org/10.1002/bjs.6914DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120264908URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: To address issues regarding the fractionation of radiotherapy (RT) and timing of surgery for rectal cancer, a multicentre trial has randomized patients to preoperative short-course RT with two different intervals to surgery, or long-course RT with delayed surgery. The present interim analysis assessed feasibility, compliance and complications after RT and surgery. METHODS: Some 303 patients were randomized to either short-course RT (5 x 5 Gy) and surgery within 1 week (group 1), short-course RT and surgery after 4-8 weeks (group 2) or long-course RT (25 x 2 Gy) and surgery after 4-8 weeks (group 3). RESULTS: Demographic data were similar between groups and there were few protocol violations (5.0-6 per cent). Eight patients (2.6 per cent) developed radiation-induced acute toxicity. There were no significant differences in postoperative complications between groups (46.6, 40.0 and 32 per cent in groups 1, 2 and 3 respectively; P = 0.164). Patients receiving short-course RT with surgery 11-17 days after the start of RT had the highest complication rate (24 of 37). CONCLUSION: Compliance was acceptable and severe acute toxicity was low, irrespective of fractionation. Short-course RT with immediate surgery had a tendency towards more postoperative complications, but only if surgery was delayed beyond 10 days after the start of RT. Registration number: NCT00904813 (http://www.clinicaltrials.gov).
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Cedermark, B.
(författare)
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Holm, T.Karolinska Institutet
(författare)
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Radu, CalinUppsala universitet,Enheten för onkologi
(författare)
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Påhlman, LarsUppsala universitet,Kolorektalkirurgi(Swepub:uu)larspahl
(författare)
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Glimelius, BengtKarolinska Institutet,Uppsala universitet,Enheten för onkologi(Swepub:uu)bengglim
(författare)
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Martling, AnnaKarolinska Institutet
(författare)
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Karolinska InstitutetEnheten för onkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Surgery: Oxford University Press (OUP)97:4, s. 580-5870007-13231365-2168
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