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The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease : a Meta-Analysis Study

Lambert, Jean-Charles (author)
Sleegers, Kristel (author)
Gonzalez-Perez, Antonio (author)
show more...
Ingelsson, Martin (author)
Uppsala universitet,Geriatrik,Molekylär geriatrik
Beecham, Gary W. (author)
Hiltunen, Mikko (author)
Combarros, Onofre (author)
Bullido, Maria J. (author)
Brouwers, Nathalie (author)
Bettens, Karolien (author)
Berr, Claudine (author)
Pasquier, Florence (author)
Richard, Florence (author)
DeKosky, Steven T. (author)
Hannequin, Didier (author)
Haines, Jonathan L. (author)
Tognoni, Gloria (author)
Fievet, Nathalie (author)
Dartigues, Jean-Francois (author)
Tzourio, Christophe (author)
Engelborghs, Sebastiaan (author)
Arosio, Beatrice (author)
Coto, Elicer (author)
De Deyn, Peter (author)
Del Zompo, Maria (author)
Mateo, Ignacio (author)
Boada, Merce (author)
Antunez, Carmen (author)
Lopez-Arrieta, Jesus (author)
Epelbaum, Jacques (author)
Schjcide, Brit-Marcn Michaud (author)
Frank-Garcia, Ana (author)
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik,Molekylär geriatrik
Helisalmi, Seppo (author)
Porcellini, Elisa (author)
Pilotto, Alberto (author)
Forti, Paola (author)
Ferri, Raffaele (author)
Delepine, Marc (author)
Zelenika, Diana (author)
Lathrop, Mark (author)
Scarpini, Elio (author)
Siciliano, Gabriele (author)
Solfrizzi, Vincenzo (author)
Sorbi, Sandro (author)
Spalletta, Gianfranco (author)
Ravaglia, Giovanni (author)
Valdivieso, Fernando (author)
Vepsäläinen, Saila (author)
University of Eastern Finland, Institute of Clinical Medicine / Neurology
Alvarez, Victoria (author)
Bosco, Paolo (author)
Mancuso, Michelangelo (author)
Panza, Francesco (author)
Nacmias, Benedetta (author)
Bossu, Paola (author)
Hanon, Olivier (author)
Piccardi, Paola (author)
Annoni, Giorgio (author)
Mann, David (author)
Marambaud, Philippe (author)
Seripa, Davide (author)
Galimberti, Daniela (author)
Tanzi, Rudolph E. (author)
Bertram, Lars (author)
Lendon, Corinne (author)
Lannfelt, Lars (author)
Uppsala universitet,Geriatrik,Molekylär geriatrik
Licastro, Federico (author)
Campion, Dominique (author)
Pericak-Vance, Margaret A. (author)
Soininen, Hilkka (author)
Van Broeckhoven, Christine (author)
Alperovitch, Annick (author)
Ruiz, Agustin (author)
Kamboh, M. Ilyas (author)
Amouyel, Philippe (author)
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 (creator_code:org_t)
2010
2010
English.
In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 22:1, s. 247-255
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.

Keyword

Age at onset
Alzheimer's disease
apolipoprotein E
CALHM1
polymorphism
MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Lambert, Jean-Ch ...
Sleegers, Kriste ...
Gonzalez-Perez, ...
Ingelsson, Marti ...
Beecham, Gary W.
Hiltunen, Mikko
show more...
Combarros, Onofr ...
Bullido, Maria J ...
Brouwers, Nathal ...
Bettens, Karolie ...
Berr, Claudine
Pasquier, Floren ...
Richard, Florenc ...
DeKosky, Steven ...
Hannequin, Didie ...
Haines, Jonathan ...
Tognoni, Gloria
Fievet, Nathalie
Dartigues, Jean- ...
Tzourio, Christo ...
Engelborghs, Seb ...
Arosio, Beatrice
Coto, Elicer
De Deyn, Peter
Del Zompo, Maria
Mateo, Ignacio
Boada, Merce
Antunez, Carmen
Lopez-Arrieta, J ...
Epelbaum, Jacque ...
Schjcide, Brit-M ...
Frank-Garcia, An ...
Giedraitis, Vilm ...
Helisalmi, Seppo
Porcellini, Elis ...
Pilotto, Alberto
Forti, Paola
Ferri, Raffaele
Delepine, Marc
Zelenika, Diana
Lathrop, Mark
Scarpini, Elio
Siciliano, Gabri ...
Solfrizzi, Vince ...
Sorbi, Sandro
Spalletta, Gianf ...
Ravaglia, Giovan ...
Valdivieso, Fern ...
Vepsäläinen, Sai ...
Alvarez, Victori ...
Bosco, Paolo
Mancuso, Michela ...
Panza, Francesco
Nacmias, Benedet ...
Bossu, Paola
Hanon, Olivier
Piccardi, Paola
Annoni, Giorgio
Mann, David
Marambaud, Phili ...
Seripa, Davide
Galimberti, Dani ...
Tanzi, Rudolph E ...
Bertram, Lars
Lendon, Corinne
Lannfelt, Lars
Licastro, Federi ...
Campion, Dominiq ...
Pericak-Vance, M ...
Soininen, Hilkka
Van Broeckhoven, ...
Alperovitch, Ann ...
Ruiz, Agustin
Kamboh, M. Ilyas
Amouyel, Philipp ...
show less...
Articles in the publication
Journal of Alzhe ...
By the university
Uppsala University

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