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Immunohistochemical...
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Fiorentino, MichelangeloDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
(författare)
Immunohistochemical Expression of BRCA1 and Lethal Prostate Cancer
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Philadelphia, USA :American Association for Cancer Research,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-135583
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135583URI
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https://doi.org/10.1158/0008-5472.CAN-09-4100DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41451URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120578854URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BRCA1 functions as a tumor suppressor; recent work suggests that BRCA1 may also induce cell cycle arrest to allow for DNA repair. We hypothesized that BRCA1 expression in prostate tumor tissue may be associated with prostate cancer progression through regulation of the cell cycle. We used immunohistochemistry to evaluate BRCA1 protein expression in archival tumor samples from 393 prostate cancer cases in the Physicians' Health Study. The men were followed prospectively from diagnosis to development of metastases and mortality. Fifteen percent of tumors stained positive for BRCA1. BRCA1-positive tumors had substantially increased tumor proliferation index compared with negative tumors (47.0 Ki67-positive nuclei versus 10.3, P = 0.0016) and were more likely to develop lethal cancer compared with BRCA1-negative tumors (hazard ratio, 4.6; 95% confidence interval, 2.4-8.7). These findings strengthen the hypothesis that BRCA1 plays a role in cell cycle control and show that BRCA1 is a marker of clinical prostate cancer prognosis. Cancer Res; 70(8); 3136-9. (C) 2010 AACR.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Judson, GregoryDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Penney, KathrynDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Flavin, RichardDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
(författare)
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Stark, JenniferDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Fiore, ChristopherDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
(författare)
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Fall, Katja,1971-Karolinska Institutet,Uppsala University Hospital(Swepub:oru)kafl
(författare)
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Martin, NeilDepartment of Epidemiology, Harvard School of Public Health, Boston, USA; Radiation Oncology, Brigham and Women's Hospital, Boston, USA
(författare)
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Ma, JingDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
(författare)
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Sinnott, JenniferDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Biostatistics, Harvard School of Public Health, Boston, USA
(författare)
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Giovannucci, EdwardDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA
(författare)
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Stampfer, MeirDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA
(författare)
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Sesso, Howard D.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
(författare)
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Kantoff, Philip W.Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA; Broad Institute, Cambridge, USA
(författare)
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Finn, StephenDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
(författare)
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Loda, MassimoDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA; Broad Institute, Cambridge, USA
(författare)
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Mucci, LoreleiDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(författare)
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Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USADepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cancer ResearchPhiladelphia, USA : American Association for Cancer Research70:8, s. 3136-31390008-54721538-7445
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Till lärosätets databas
- Av författaren/redakt...
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Fiorentino, Mich ...
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Judson, Gregory
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Penney, Kathryn
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Flavin, Richard
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Stark, Jennifer
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Fiore, Christoph ...
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visa fler...
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Fall, Katja, 197 ...
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Martin, Neil
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Ma, Jing
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Sinnott, Jennife ...
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Giovannucci, Edw ...
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Stampfer, Meir
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Sesso, Howard D.
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Kantoff, Philip ...
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Finn, Stephen
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Loda, Massimo
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Mucci, Lorelei
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visa färre...
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Cancer Research
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Uppsala universitet
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