Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: swepub > Overweight, obesity...

Overweight, obesity, and risk of cardiometabolic multimorbidity : pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

Kivimäki, Mika (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Finnish Institute of Occupational Health, Helsinki, Finland,UCL, Dept Epidemiol & Publ Hlth, London, England; Univ Helsinki, Dept Publ Hlth, Fac Med, Helsinki, Finland; Finnish Inst Occupat Hlth, Helsinki, Finland

Kuosma, Eeva (författare): Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Dept Publ Hlth, Fac Med, Helsinki, Finland

Ferrie, Jane E. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England; Univ Bristol, Sch Social & Community Med, Bristol, Avon, England

visa fler...

Luukkonen, Ritva (författare): Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Dept Publ Hlth, Fac Med, Helsinki, Finland

Nyberg, Solja T. (författare): Karolinska Institutet

Alfredsson, Lars (författare): Karolinska Institutet

Batty, G David. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England

Brunner, Eric J. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England

Fransson, Eleonor I., 1971- (författare): Stockholms universitet,Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,HHJ. ARN-J (Aging Research Network - Jönköping),Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden / Stress Research Institute, Stockholm University, Stockholm, Sweden / School of Health Sciences, Jönköping University, Jönköping, Sweden,Stressforskningsinstitutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Stockholm Univ, Stress Res Inst, Stockholm, Sweden; Jönköping Univ, Sch Hlth Sci, Jönköping, Sweden

Goldberg, Marcel (författare): Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France,INSERM, UMS 011, Population Based Epidemiol Cohorts Unit, Villejuif, France

Knutsson, Anders, 1942- (författare): Mittuniversitetet,Avdelningen för hälsovetenskap,Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden,Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden

Koskenvuo, Markku (författare): Department of Public Health, University of Helsinki, Helsinki, Finland,Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

Nordin, Maria (författare): Umeå universitet,Institutionen för psykologi,Stress Research Institute, Stockholm University, Stockholm, Sweden / Department of Psychology, Umeå University, Umeå, Sweden,Stockholm Univ, Stress Res Inst, Stockholm, Sweden; Umeå Univ, Dept Psychol, Umeå, Sweden

Oksanen, Tuula (författare): Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland

Pentti, Jaana (författare): Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland

Rugulies, Reiner (författare): Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark / National Research Centre for the Working Environment, Copenhagen, Denmark,Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark; Univ Copenhagen, Dept Psychol, Copenhagen, Denmark; Natl Res Ctr Working Environm, Copenhagen, Denmark

Shipley, Martin J. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England

Singh-Manoux, Archana (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France,UCL, Dept Epidemiol & Publ Hlth, London, England; INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, Villejuif, France

Steptoe, Andrew (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England

Suominen, Sakari B. (författare): Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Public Health, University of Turku, Turku, Finland, Folkhälsan Research Center, Helsinki, Finland, University of Skövde, Skövde, Sweden,Individ och samhälle, Individual and Society (VIDSOC),Univ Turku, Dept Publ Hlth, Turku, Finland; Folkhälsan Res Ctr, Helsinki, Finland; Univ Skövde, Skövde, Sweden

Theorell, Töres (författare): Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France

Vahtera, Jussi (författare): Department of Public Health, University of Turku, Turku, Finland / Turku University Hospital, Turku, Finland,Univ Turku, Dept Publ Hlth, Turku, Finland; Turku Univ Hosp, Turku, Finland

Virtanen, Marianna (författare): Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland

Westerholm, Peter (författare): Uppsala universitet,Arbets- och miljömedicin

Westerlund, Hugo (författare): Stockholms universitet,Stressforskningsinstitutet,Stockholm Univ, Stress Res Inst, Stockholm, Sweden

Zins, Marie (författare): Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France,INSERM, UMS 011, Population Based Epidemiol Cohorts Unit, Villejuif, France

Hamer, Mark (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / National Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England; Loughborough Univ Technol, Natl Ctr Sport & Exercise Med, Loughborough, Leics, England

Bell, Joshua A. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, London, England; Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England

Tabak, Adam G. (författare): Department of Epidemiology and Public Health, University College London, London, United Kingdom / 1st Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary,UCL, Dept Epidemiol & Publ Hlth, London, England; Semmelweis Univ, Dept Med 1, Fac Med, Budapest, Hungary

Jokela, Markus (författare): Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland,Univ Helsinki, Inst Behav Sci, Helsinki, Finland

visa färre...

(creator_code:org_t)

The Lancet Publishing Group, 2017
2017
Engelska.
Ingår i: The Lancet Public Health. - : The Lancet Publishing Group. - 2468-2667. ; 2:6, s. e277-e285

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://his.diva-por... (primary) (Raw object); https://miun.diva-po... (primary) (Raw object); https://hj.diva-port... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

BACKGROUND: Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is poorly understood. Here we aimed to establish the risk of incident cardiometabolic multimorbidity (ie, at least two from: type 2 diabetes, coronary heart disease, and stroke) in adults who are overweight and obese compared with those who are a healthy weight.METHODS: ) to achieve sufficient case numbers for analysis. The main outcome was cardiometabolic multimorbidity (ie, developing at least two from: type 2 diabetes, coronary heart disease, and stroke). Incident cardiometabolic multimorbidity was ascertained via resurvey or linkage to electronic medical records (including hospital admissions and death). We analysed data from each cohort separately using logistic regression and then pooled cohort-specific estimates using random-effects meta-analysis.FINDINGS: Participants were 120 813 adults (mean age 51·4 years, range 35-103; 71 445 women) who did not have diabetes, coronary heart disease, or stroke at study baseline (1973-2012). During a mean follow-up of 10·7 years (1995-2014), we identified 1627 cases of multimorbidity. After adjustment for sociodemographic and lifestyle factors, compared with individuals with a healthy weight, the risk of developing cardiometabolic multimorbidity in overweight individuals was twice as high (odds ratio [OR] 2·0, 95% CI 1·7-2·4; p<0·0001), almost five times higher for individuals with class I obesity (4·5, 3·5-5·8; p<0·0001), and almost 15 times higher for individuals with classes II and III obesity combined (14·5, 10·1-21·0; p<0·0001). This association was noted in men and women, young and old, and white and non-white participants, and was not dependent on the method of exposure assessment or outcome ascertainment. In analyses of different combinations of cardiometabolic conditions, odds ratios associated with classes II and III obesity were 2·2 (95% CI 1·9-2·6) for vascular disease only (coronary heart disease or stroke), 12·0 (8·1-17·9) for vascular disease followed by diabetes, 18·6 (16·6-20·9) for diabetes only, and 29·8 (21·7-40·8) for diabetes followed by vascular disease.INTERPRETATION: The risk of cardiometabolic multimorbidity increases as BMI increases; from double in overweight people to more than ten times in severely obese people compared with individuals with a healthy BMI. Our findings highlight the need for clinicians to actively screen for diabetes in overweight and obese patients with vascular disease, and pay increased attention to prevention of vascular disease in obese individuals with diabetes.FUNDING: NordForsk, Medical Research Council, Cancer Research UK, Finnish Work Environment Fund, and Academy of Finland.

Hitta via bibliotek

The Lancet Public Health (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: The Lancet Publi ...; The Lancet

Av lärosätet: Högskolan i Skövde; Umeå universitet; Mittuniversitetet; Jönköping University; Stockholms universitet; Uppsala universitet; visa fler...; Karolinska Institutet; visa färre...

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Overweight, obesity, and risk of cardiometabolic multimorbidity : pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub