Temperature stability and denaturation of serum albumin

• It has been shown by Svedberg and Sjögren1 that at ordinary temperature serum albumin is stable (that is, homogeneous with regard to molecular weight) in a region of pH varying between 4 and 9. These authors have also shown that outside of the stability region, but not too far from it, the serum albumin molecule is dissociated into smaller molecules. This first stage of breaking up of the molecule probably means the formation of particles of half the weight of the original molecule. The complete breaking up of the molecule follows immediately after this stage. The first stage has been shown to be reversible with regard to the molecular weight.

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NATURVETENSKAP  -- Kemi -- Fysikalisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Physical Chemistry (hsv//eng)

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