Tyck till om SwePub Sök här!
WFRF:(Palotie Aarno)
Search: WFRF:(Palotie Aarno) > Effects of pnpla3 i...
- 5 of 64
- Previous record
- Next record
- To hitlist
Effects of pnpla3 i148m on hepatic lipid and very low-density lipoprotein metabolism in humans.
-
- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
-
- Adiels, Martin, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
-
- Björnson, Elias, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory
- show more...
- Matikainen, Niina (author)
- Söderlund, Sanni (author)
- Rämö, Joel (author)
- Ripatti, Pietari (author)
- Ripatti, Samuli (author)
- Palotie, Aarno (author)
- Ainola, Mari (author)
- Hakkarainen, Antti (author)
- Packard, Chris J (author)
- Taskinen, Marja-Riitta (author)
- show less...
- (creator_code:org_t)
- 2021-09-26
- 2022
- English.
- In: Journal of internal medicine. - : Wiley. - 1365-2796 .- 0954-6820. ; 291:2, s. 218-223
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The PNPLA3-148M variant is associated with liver steatosis but its influence on metabolism of triglyceride-rich lipoproteins remains unclear. Here we investigated the kinetics of large, triglyceride-rich VLDL1 and smaller VLDL2 in homozygotes for the PNPLA3-148M variant.The kinetics of apoB100 and triglyceride in VLDL subfractions was analysed in nine subjects homozygous for PNPLA3-148M and nine subjects homozygous for PNPLA3-148I (controls). Liver fat was >3-fold higher in the 148M subjects. Production rates for apoB100 and triglyceride in VLDL1 did not differ significantly between the two groups. Likewise, production rates for VLDL2 -apoB100 and -triglyceride, and fractional clearance rates for both apoB100 and triglyceride in VLDL1 and VLDL2 , were not significantly different.Despite the higher liver fat content in PNPLA3-148M homozygotes, there was no increase in VLDL production. Equally, VLDL production was maintained at normal levels despite the putative impairment in cytosolic lipid hydrolysis in these subjects. This article is protected by copyright. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Journal of internal medicine (Search for host publication in LIBRIS)
To the university's database
- 5 of 64
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Borén, Jan, 1963
- Adiels, Martin, ...
- Björnson, Elias, ...
- Matikainen, Niin ...
- Söderlund, Sanni
- Rämö, Joel
- show more...
- Ståhlman, Marcus ...
- Ripatti, Pietari
- Ripatti, Samuli
- Palotie, Aarno
- Mancina, Roselli ...
- Ainola, Mari
- Hakkarainen, Ant ...
- Romeo, Stefano, ...
- Packard, Chris J
- Taskinen, Marja- ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Journal of inter ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
