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A prognostic model predicting autologous transplantation outcomes in children, adolescents and young adults with Hodgkin lymphoma
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- Satwani, P. (author)
- Columbia Univ, Dept Pediat, Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA.
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- Ahn, K. W. (author)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- Carreras, J. (author)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Keating, A. (author)
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- Columbia Univ, Dept Pediat, Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY 10027 USA Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
- 2015-08-03
- 2015
- English.
- In: Bone Marrow Transplantation. - : Springer Science and Business Media LLC. - 0268-3369 .- 1476-5365. ; 50:11, s. 1416-1423
- Journal article (peer-reviewed)
Abstract
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- Autologous hematopoietic cell transplantation (AutoHCT) is a potentially curative treatment modality for relapsed/ refractory Hodgkin lymphoma (HL). However, no large studies have evaluated pretransplant factors predictive of outcomes of AutoHCT in children, adolescents and young adults (CAYA, age < 30 years). In a retrospective study, we analyzed 606 CAYA patients (median age 23 years) with relapsed/refractory HL who underwent AutoHCT between 1995 and 2010. The probabilities of PFS at 1, 5 and 10 years were 66% (95% confidence interval (CI): 62-70), 52% (95% CI: 48-57) and 47% (95% CI: 42-51), respectively. Multivariate analysis for PFS demonstrated that at the time of AutoHCT patients with Karnofsky/Lansky score >= 90, no extranodal involvement and chemosensitive disease had significantly improved PFS. Patients with time from diagnosis to first relapse of < 1 year had a significantly inferior PFS. A prognostic model for PFS was developed that stratified patients into low-, intermediate-and high-risk groups, predicting for 5-year PFS probabilities of 72% (95% CI: 64-80), 53% (95% CI: 47-59) and 23% (95% CI: 9-36), respectively. This large study identifies a group of CAYA patients with relapsed/refractory HL who are at high risk of progression after AutoHCT. Such patients should be targeted for novel therapeutic and/or maintenance approaches post-AutoHCT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- art (subject category)
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- Satwani, P.
- Ahn, K. W.
- Carreras, J.
- Abdel-Azim, H.
- Cairo, M. S.
- Cashen, A.
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- Chen, A. I.
- Cohen, J. B.
- Costa, L. J.
- Dandoy, C.
- Fenske, T. S.
- Freytes, C. O.
- Ganguly, S.
- Gale, R. P.
- Ghosh, N.
- Hertzberg, M. S.
- Hayashi, R. J.
- Kamble, R. T.
- Kanate, A. S.
- Keating, A.
- Kharfan-Dabaja, ...
- Lazarus, H. M.
- Marks, D. I.
- Nishihori, T.
- Olsson, R. F.
- Prestidge, T. D.
- Rolon, J. M.
- Savani, B. N.
- Vose, J. M.
- Wood, W. A.
- Inwards, D. J.
- Bachanova, V.
- Smith, S. M.
- Maloney, D. G.
- Sureda, A.
- Hamadani, M.
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- MEDICAL AND HEALTH SCIENCES
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- Uppsala University
- Karolinska Institutet
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