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WFRF:(Sahni A)
 

Sökning: WFRF:(Sahni A) > Widespread Expansio...

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

Yang, Xinping (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou 510515, Guangdong, Peoples R China.
Coulombe-Huntington, Jasmin (författare)
McGill Univ, Dept Bioengn, Montreal, PQ H3A 0C3, Canada.;Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada.
Kang, Shuli (författare)
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;Univ So Calif, Dept Biol Sci, Mol & Computat Biol Program, Los Angeles, CA 90089 USA.
visa fler...
Sheynkman, Gloria M. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Hao, Tong (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Richardson, Aaron (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Sun, Song (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
Yang, Fan (författare)
Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
Shen, Yun A. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Murray, Ryan R. (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Univ Helsinki, Biomedicum Helsinki 1, FIN-00290 Helsinki, Finland.
Spirohn, Kerstin (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Begg, Bridget E. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;MIT, Dept Biol, Cambridge, MA 02139 USA.
Duran-Frigola, Miquel (författare)
Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain.
MacWilliams, Andrew (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Tecan US Inc, Morrisville, NC 27560 USA.
Pevzner, Samuel J. (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.;Boston Univ, Sch Med, Boston, MA 02118 USA.
Zhong, Quan (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Wright State Univ, Dept Biol Sci, Dayton, OH 45435 USA.
Trigg, Shelly A. (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Univ Calif San Diego, Dept Biol Sci, La Jolla, CA 92093 USA.
Tam, Stanley (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
Ghamsari, Lila (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Genocea Biosci Inc, Cambridge, MA 02140 USA.
Sahni, Nidhi (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Yi, Song (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Rodriguez, Maria D. (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Cedars Sinai Med Ctr, Biomed Sci & Translat Med, Los Angeles, CA 90048 USA.
Balcha, Dawit (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Tan, Guihong (författare)
Costanzo, Michael (författare)
Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.
Andrews, Brenda (författare)
Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.
Boone, Charles (författare)
Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.
Zhou, Xianghong J. (författare)
Univ So Calif, Dept Biol Sci, Mol & Computat Biol Program, Los Angeles, CA 90089 USA.
Salehi-Ashtiani, Kourosh (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;New York Univ Abu Dhabi, Div Sci & Math, Abu Dhabi, U Arab Emirates.;New York Univ Abu Dhabi, Ctr Genom & Syst Biol CGSB, Abu Dhabi, U Arab Emirates.
Charloteaux, Benoit (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Univ Liege, Unit Anim Genom, GIGA R, B-4000 Liege, Belgium.;Univ Liege, Fac Vet Med, B-4000 Liege, Belgium.
Chen, Alyce A. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Calderwood, Michael A. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Aloy, Patrick (författare)
Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain.;ICREA, Barcelona 08010, Catalonia, Spain.
Roth, Frederick P. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada.;Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.;Canadian Inst Adv Res, Toronto, ON M5G 1Z8, Canada.
Hill, David E. (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
Iakoucheva, Lilia M. (författare)
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
Xia, Yu (författare)
Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;McGill Univ, Dept Bioengn, Montreal, PQ H3A 0C3, Canada.
Vidal, Marc (författare)
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA.;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
visa färre...
Dana Farber Canc Inst, Genom Anal Network Perturbat Ctr Excellence Genom, Boston, MA 02215 USA;Dana Farber Canc Inst, Ctr Canc Syst Biol CCSB, Boston, MA 02215 USA.;Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.;Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou 510515, Guangdong, Peoples R China. McGill Univ, Dept Bioengn, Montreal, PQ H3A 0C3, Canada.;Univ Montreal, Inst Res Immunol & Canc, Montreal, PQ H3C 3J7, Canada. (creator_code:org_t)
Elsevier BV, 2016
2016
Engelska.
Ingår i: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 164:4, s. 805-817
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs. The majority of isoform pairs share less than 50% of their interactions. In the global context of interactome network maps, alternative isoforms tend to behave like distinct proteins rather than minor variants of each other. Interaction partners specific to alternative isoforms tend to be expressed in a highly tissue-specific manner and belong to distinct functional modules. Our strategy, applicable to other functional characteristics, reveals a widespread expansion of protein interaction capabilities through alternative splicing and suggests that many alternative "isoforms'' are functionally divergent (i.e., "functional alloforms'').

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

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