Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

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Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Drakvik, E. (författare): Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, Stockholm, Sweden,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden;Stockholm Univ, ACES, SE-10691 Stockholm, Sweden

Altenburger, R. (författare): Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany

Aoki, Y. (författare): National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan,Natl Inst Environm Studies, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan

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Backhaus, Thomas, 1967 (författare): Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg, Department of Biological and Environmental Sciences, Gothenburg, Sweden,Univ Gothenburg, Dept Biol & Environm Sci, Box 461, SE-40530 Gothenburg, Sweden

Bahadori, T. (författare): US Environmental Protection Agency, 1200 Pennsylvania Ave, NW, MC 8201R, Washington, DC, USA,US EPA, 1200 Penn Ave NW,MC 8201R, Washington, DC 20460 USA

Barouki, R. (författare): Université de Paris, Inserm Unit 1124, Paris, France,Univ Paris, Inserm Unit 1124, 45 Rue St Peres, F-75006 Paris, France

Brack, W. (författare): Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany; RWTH Aachen University Institute for Environmental Research, ABBt-aachen Biology, Aachen, Germany,UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany;Rhein Westfal TH Aachen, Inst Environm Res, ABBt Aachen Biol, Worringerweg 1, D-52074 Aachen, Germany

Cronin, M. T. D. (författare): Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UK,Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England

Demeneix, B. (författare): Muséum National d'Histoire Naturelle (MNHN) UMR 7221 (CNRS/MNHN), Paris, France,CNRS, MNHN, UMR 7221, 7 Rue Cuvier, F-75005 Paris, France

Hougaard Bennekou, S. (författare): Danish Technical University, FOOD, Kemitorvet 201. Lyngby, Denmark,Danish Tech Univ, FOOD, Kemitorvet 201, DK-2800 Lyngby, Denmark

van Klaveren, J. (författare): National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands

Kneuer, C. (författare): German Federal Institute for Risk Assessment, Pesticide Safety, German Federal Institute for Risk Assessment, Berlin, Germany,German Fed Inst Risk Assessment, Pesticide Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany

Kolossa-Gehring, M. (författare): German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany

Lebret, E. (författare): National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Utrecht, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Univ Utrecht, IRAS, Yalelaan 2, NL-3584 CM Utrecht, Netherlands

Posthuma, L. (författare): National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Radboud University, Department of Environmental Science, Institute for Water and Wetland Research, Nijmegen, the Netherlands,Natl Inst Publ Hlth & Environm RIVM, POB 1, NL-3720 BA Bilthoven, Netherlands;Radboud Univ Nijmegen, Dept Environm Sci, Inst Water & Wetland Res, Nijmegen, Netherlands

Reiber, L. (författare): German Environment Agency (UBA), Berlin, Germany,German Environm Agcy UBA, Correnspl 1, D-14195 Berlin, Germany

Rider, C. (författare): National Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC, USA,NIEHS, Natl Toxicol Program, 111 TW Alexander Dr,POB 12233,MD K2-12, Res Triangle Pk, NC 27709 USA

Ruegg, Joëlle (författare): Karolinska Institutet,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden

Testa, G. (författare): University of Milan, Department of Oncology, Via S. Sofia, 9/1, 20122 Milan, Italy; IEO European Institute of Oncology, Milan, Italy,Univ Milan, Dept Oncol, Via S Sofia 9-1, I-20122 Milan, Italy;IEO, Via Adamello 16, I-20139 Milan, Italy

van der Burg, B. (författare): BioDetection Systems, Amsterdam, the Netherlands,BioDetect Syst, Sci Pk 406, NL-1098 XH Amsterdam, Netherlands

van der Voet, H. (författare): Wageningen University & Research, Wageningen, the Netherlands,Wageningen Univ & Res, Droevendaalsesteeg 1, NL-6708 PB Wageningen, Netherlands

Warhurst, A. M. (författare): CHEM Trust, 34b York Way, London N1 9AB, England

van de Water, B. (författare): Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands,Leiden Univ, Leiden Acad Ctr Drug Res, POB 9502, NL-2300 RA Leiden, Netherlands

Yamazaki, K. (författare): Ministry of the Environment, Japan, Chiyoda-ku, Tokyo, Japan,Minist Environm Japan, Chiyoda Ku, 1-2-2 Kasumigaseki, Tokyo 1008975, Japan

Öberg, M. (författare): Karolinska Institutet

Bergman, Åke, 1950- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Stockholm University, ACES, Stockholm, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, China,Stockholm Univ, ACES, SE-10691 Stockholm, Sweden;Orebro Univ, Dept Sci & Technol, SE-70182 Orebro, Sweden;Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China

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Elsevier BV, 2020
2020
Engelska.
Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 134

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: • We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures. • Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors. • Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps. • A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient. © 2019 The Authors

Ämnesord

NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)

Nyckelord

Chemical mixtures
Combined exposure
Environmental chemicals
Mixture risk assessment
Risk management
Animals
Environmental management
Hazardous materials
Hazards
Health risks
Indicators (chemical)
Metabolites
Mixtures
Pollution control
Public health
Anthropogenic chemicals
Joint Research centers
Precautionary approach
Stakeholder engagement
Transformation products
Risk assessment
dangerous goods
drug mixture
human
letter
wildlife
Chemical mixtures

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