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  • Geyer, Holly L.Mayo Clin, Div Hosp Internal Med, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)

The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life : An analysis by the MPN QOL International Study Group

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-04-12
  • Wiley,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-299896
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-299896URI
  • https://doi.org/10.1002/cncr.30013DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133811232URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUNDPatients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODSA total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTSOverall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P<.001), with 64% of patients with MPN describing some degree of sexual dysfunction and 43% experiencing severe symptoms. The presence of sexual symptoms correlated closely with all domains of patient functionality (physical, social, cognitive, emotional, and role functioning) and were associated with a reduced quality of life. Sexual problems also were found to be associated with other MPN symptoms, particularly depression and nocturnal and microvascular-related symptoms. Sexual dysfunction was more severe in patients aged >65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. ConclusionsThe results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management. Cancer 2016;122:1888-96. (c) 2016 American Cancer Society. Sexuality problems impact all domains of functionality, depression, microvascular symptoms, and overall quality of life among patients with myeloproliferative neoplasms. These problems correlate with patient age, the presence of cytopenias, transfusion requirements, and common therapies for myeloproliferative neoplasms. See also pages 1804-6.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andreasson, BjornNU Hosp Org, Internal Med, Uddevalla, Sweden. (författare)
  • Kosiorek, Heidi E.Mayo Clin, Sect Biostat, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)
  • Dueck, Amylou C.Mayo Clin, Sect Biostat, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)
  • Scherber, Robyn M.Oregon Hlth & Sci Univ, Dept Hematol & Oncol, Portland, OR 97201 USA. (författare)
  • Martin, Kari A.Mayo Clin, Dept Psychiat, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)
  • Butler, Kristina A.Mayo Clin, Dept Gynecol, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)
  • Harrison, Claire N.Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England. (författare)
  • Radia, Deepti H.Guys & St Thomas NHS Fdn Trust, Dept Haematol, London, England. (författare)
  • Cervantes, FranciscoUniv Barcelona, Dept Hematol, Hosp Clin, IDIBAPS, Barcelona, Spain. (författare)
  • Kiladjian, Jean-JacquesHosp St Louis, Clin Invest Ctr, Paris, France. (författare)
  • Reiter, AndreasUniv Mannheim, Med Clin, D-68131 Mannheim, Germany. (författare)
  • Birgegård, GunnarUppsala universitet,Hematologi(Swepub:uu)gunnarbg (författare)
  • Passamonti, FrancescoUniv Pavia, Dept Hematol, IRCCS Fdn San Matteo Polyclin, Via Palestro 3, I-27100 Pavia, Italy. (författare)
  • Senyak, ZhenyaMPN Forum, Asheville, NC USA. (författare)
  • Vannucchi, Alessandro M.Circolo Hosp, Div Hematol, Varese, Italy. (författare)
  • Paoli, ChiaraUniv Florence, Dept Med, Florence, Italy. (författare)
  • Xiao, ZhijianChinese Acad Med Sci, Inst Hematol, MDS & MPN Ctr, Tianjin, Peoples R China.;Chinese Acad Med Sci, Blood Dis Hosp, Tianjin, Peoples R China.;Peking Union Med Coll, Tianjin, Peoples R China. (författare)
  • Samuelsson, JanKarolinska Institutet (författare)
  • Mesa, Ruben A.Mayo Clin, Div Hematol Oncol, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA. (författare)
  • Mayo Clin, Div Hosp Internal Med, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA.NU Hosp Org, Internal Med, Uddevalla, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer: Wiley122:12, s. 1888-18960008-543X1097-0142

Internetlänk

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  • Cancer (Sök värdpublikationen i LIBRIS)

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