Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data

Tyck till om SwePub Sök här!

Converging evidence suggests that bipolar disorder (BD) is associated with white matter (WM) abnormalities. Meta-analyses of voxel based morphometry (VBM) data is commonly performed using published coordinates, however this method is limited since it ignores non-significant data. Obtaining statistical maps from studies (T-maps) as well as raw MRI datasets increases accuracy and allows for a comprehensive analysis of clinical variables. We obtained coordinate data (7-studies), T-Maps (12-studies, including unpublished data) and raw MRI datasets (5-studies) and analysed the 24 studies using Seed-based d Mapping (SDM). A VBM analysis was conducted to verify the results in an independent sample. The meta-analysis revealed decreased WM volume in the posterior corpus callosum extending to WM in the posterior cingulate cortex. This region was significantly reduced in volume in BD patients in the independent dataset (p=0.003) but there was no association with clinical variables. We identified a robust WM volume abnormality in BD patients that may represent a trait marker of the disease and used a novel methodology to validate the findings.

Emsell, Louise (författare)
Yip, Sarah W (författare)
Dima, Danai (författare)
Giannakopoulos, Panteleimon (författare)
Zarei, Mojtaba (författare)
Tognin, Stefania (författare)
Arnone, Danilo (författare)
James, Anthony (författare)
Haller, SvenUppsala universitet,Radiologi,Affidea CDRC Ctr Diagnost Radiol Carouge, Carouge, Switzerland; Univ Hosp Freiburg, Dept Neuroradiol, Freiburg, Germany; Univ Geneva, Fac Med, Geneva, Switzerland(Swepub:uu)sveha228 (författare)
Frangou, Sophia (författare)
Goodwin, Guy M (författare)
McDonald, Colm (författare)
Kempton, Matthew J (författare)
Uppsala universitetRadiologi (creator_code:org_t)

Ingår i:Neuroscience and Biobehavioral Reviews: Elsevier BV84, s. 162-1700149-76341873-7528

Av författaren/redakt...: Pezzoli, Stefani ...; Emsell, Louise; Yip, Sarah W; Dima, Danai; Giannakopoulos, ...; Zarei, Mojtaba; visa fler...; Tognin, Stefania; Arnone, Danilo; James, Anthony; Haller, Sven; Frangou, Sophia; Goodwin, Guy M; McDonald, Colm; Kempton, Matthew ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.