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Genome-wide associa...
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Otto, Marcia C. de OliveiraUniv Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA
(författare)
Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids : Results from the CHARGE Consortium
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-05-08
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Public Library of Science (PLoS),2018
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-356495
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356495URI
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https://doi.org/10.1371/journal.pone.0196951DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.
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Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
(författare)
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Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
(författare)
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King, Irena B.Univ New Mexico, Albuquerque, NM USA
(författare)
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Wu, Jason H. Y.Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; Univ New South Wales, Fac Med, Sydney, NSW, Australia
(författare)
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Manichaikul, AniUniv Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
(författare)
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Rich, Stephen S.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
(författare)
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Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA
(författare)
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Chen, Y. D.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA USA
(författare)
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Fornage, MyriamUniv Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Key Lab Nutr & Metab, Houston, TX USA
(författare)
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Weihua, GuanUniv Minnesota, Dept Biostat, Minneapolis, MN USA
(författare)
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Aslibekyan, StellaUniv Kentucky, Coll Publ Hlth, Lexington, KY USA
(författare)
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Irvin, Marguerite R.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
(författare)
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Kabagambe, Edmond K.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
(författare)
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Arnett, Donna K.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA
(författare)
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Jensen, Majken K.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA;Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Boston, MA USA
(författare)
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McKnight, BarbaraUniv Washington, Dept Biostat, Seattle, WA USA
(författare)
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Psaty, Bruce M.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA
(författare)
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Steffen, Lyn M.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
(författare)
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Smith, Caren E.Tufts Univ, Jean Mayer USDA HNRCA, Nutr & Genom Lab, Boston, MA USA
(författare)
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Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(författare)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(författare)
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Hu, Frank B.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
(författare)
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Rimm, Eric B.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA
(författare)
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Siscovick, David S.New York Acad Med, New York, NY USA
(författare)
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Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA
(författare)
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Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USAUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
(creator_code:org_t)
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Ingår i:PLOS ONE: Public Library of Science (PLoS)13:51932-6203
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Otto, Marcia C. ...
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Lemaitre, Rozenn ...
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Sun, Qi
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King, Irena B.
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Wu, Jason H. Y.
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Manichaikul, Ani
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visa fler...
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Rich, Stephen S.
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Tsai, Michael Y.
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Chen, Y. D.
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Fornage, Myriam
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Weihua, Guan
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Aslibekyan, Stel ...
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Irvin, Marguerit ...
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Kabagambe, Edmon ...
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Arnett, Donna K.
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Jensen, Majken K ...
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McKnight, Barbar ...
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Psaty, Bruce M.
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Steffen, Lyn M.
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Smith, Caren E.
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Risérus, Ulf, 19 ...
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Lind, Lars
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Hu, Frank B.
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Rimm, Eric B.
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Siscovick, David ...
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Mozaffarian, Dar ...
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