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Sökning: WFRF:(Guan Weihua) > (2018) > Genome-wide associa...

  • Otto, Marcia C. de OliveiraUniv Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA (författare)

Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids : Results from the CHARGE Consortium

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-05-08
  • Public Library of Science (PLoS),2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-356495
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356495URI
  • https://doi.org/10.1371/journal.pone.0196951DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Odd-numbered chain saturated fatty acids (OCSFA) have been associated with potential health benefits. Although some OCSFA (e.g., C15:0 and C17:0) are found in meats and dairy products, sources and metabolism of C19:0 and C23:0 are relatively unknown, and the influence of non-dietary determinants, including genetic factors, on circulating levels of OCSFA is not established.Objective: To elucidate the biological processes that influence circulating levels of OCSFA by investigating associations between genetic variation and OCSFA.Design: We performed a meta-analysis of genome-wide association studies (GWAS) of plasma phospholipid/erythrocyte levels of C15:0, C17:0, C19:0, and C23:0 among 11,494 individuals of European descent. We also investigated relationships between specific single nucleotide polymorphisms (SNPs) in the lactase (LCT) gene, associated with adult-onset lactase intolerance, with circulating levels of dairy-derived OCSFA, and evaluated associations of candidate sphingolipid genes with C23:0 levels.Results: We found no genome-wide significant evidence that common genetic variation is associated with circulating levels of C15:0 or C23:0. In two cohorts with available data, we identified one intronic SNP (rs13361131) in myosin X gene (MYO10) associated with C17:0 level (P = 1.37×10−8), and two intronic SNP (rs12874278 and rs17363566) in deleted in lymphocytic leukemia 1 (DLEU1) region associated with C19:0 level (P = 7.07×10−9). In contrast, when using a candidate-gene approach, we found evidence that three SNPs in LCT (rs11884924, rs16832067, and rs3816088) are associated with circulating C17:0 level (adjusted P = 4×10−2). In addition, nine SNPs in the ceramide synthase 4 (CERS4) region were associated with circulating C23:0 levels (adjusted P<5×10−2).Conclusions: Our findings suggest that circulating levels of OCSFA may be predominantly influenced by non-genetic factors. SNPs associated with C17:0 level in the LCT gene may reflect genetic influence in dairy consumption or in metabolism of dairy foods. SNPs associated with C23:0 may reflect a role of genetic factors in the synthesis of sphingomyelin.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA (författare)
  • Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA (författare)
  • King, Irena B.Univ New Mexico, Albuquerque, NM USA (författare)
  • Wu, Jason H. Y.Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; Univ New South Wales, Fac Med, Sydney, NSW, Australia (författare)
  • Manichaikul, AniUniv Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA (författare)
  • Rich, Stephen S.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA (författare)
  • Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA (författare)
  • Chen, Y. D.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Los Angeles Biomed Res Inst, Torrance, CA USA (författare)
  • Fornage, MyriamUniv Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Key Lab Nutr & Metab, Houston, TX USA (författare)
  • Weihua, GuanUniv Minnesota, Dept Biostat, Minneapolis, MN USA (författare)
  • Aslibekyan, StellaUniv Kentucky, Coll Publ Hlth, Lexington, KY USA (författare)
  • Irvin, Marguerite R.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA (författare)
  • Kabagambe, Edmond K.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA (författare)
  • Arnett, Donna K.Univ Kentucky, Coll Publ Hlth, Lexington, KY USA (författare)
  • Jensen, Majken K.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA;Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Boston, MA USA (författare)
  • McKnight, BarbaraUniv Washington, Dept Biostat, Seattle, WA USA (författare)
  • Psaty, Bruce M.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA (författare)
  • Steffen, Lyn M.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA (författare)
  • Smith, Caren E.Tufts Univ, Jean Mayer USDA HNRCA, Nutr & Genom Lab, Boston, MA USA (författare)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
  • Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (författare)
  • Hu, Frank B.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA (författare)
  • Rimm, Eric B.Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA; Channing Div Network Med, Boston, MA USA; Harvard Med Sch, Boston, MA USA (författare)
  • Siscovick, David S.New York Acad Med, New York, NY USA (författare)
  • Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA USA (författare)
  • Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USAUniv Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: Public Library of Science (PLoS)13:51932-6203

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  • PLOS ONE (Sök värdpublikationen i LIBRIS)

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