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  • Watts, Eleanor L.Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England (författare)

Low Free Testosterone and Prostate Cancer Risk : A Collaborative Analysis of 20 Prospective Studies

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • Elsevier,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-368367
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368367URI
  • https://doi.org/10.1016/j.eururo.2018.07.024DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective: To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants: Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis: Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations: Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69-0.86; p < 0.001) compared with men with higher concentrations (2nd-10th tenths of the distribution). Heterogeneity was present by tumour grade (p(het) = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67-0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95-2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions: Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary: In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer. (c) 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Appleby, Paul N.Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England (författare)
  • Perez-Cornago, AuroraUniv Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England (författare)
  • Bueno-de-Mesquita, H. BasNatl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Malaya, Dept Social & Prevent Med, Kuala Lumpur, Malaysia (författare)
  • Chan, June M.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Urol, San Francisco, CA USA (författare)
  • Chen, ChuFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA (författare)
  • Cohn, Barbara A.Publ Hlth Inst, Child Hlth & Dev Studies, Berkeley, CA USA (författare)
  • Cook, Michael B.US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA (författare)
  • Flicker, LeonUniv Western Australia, Sch Med, Perth, WA, Australia;Univ Western Australia, Med Res Ctr, Western Australian Ctr Hlth & Ageing, Perth, WA, Australia (författare)
  • Freedman, Neal D.US Natl Canc Inst, Div Canc Epidemiol & Genet, Bethesda, MD USA (författare)
  • Giles, Graham G.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia (författare)
  • Giovannucci, EdwardHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA;Publ Hlth Directorate, Asturias, Spain;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA (författare)
  • Gislefoss, Randi E.Inst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway (författare)
  • Hankey, Graeme J.Univ Western Australia, Sch Med, Perth, WA, Australia (författare)
  • Kaaks, RudolfGerman Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany (författare)
  • Knekt, PaulNatl Inst Hlth & Welf, Helsinki, Finland (författare)
  • Kolonel, Laurence N.Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA (författare)
  • Kubo, TatsuhikoUniv Occupat & Environm Hlth, Dept Prevent Med & Community Hlth, Kitakyushu, Fukuoka, Japan (författare)
  • Le Marchand, LoicUniv Hawaii, Ctr Canc, Honolulu, HI 96822 USA (författare)
  • Luben, Robert N.Univ Cambridge, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge, England (författare)
  • Luostarinen, TapioInst Stat & Epidemiol Canc Res, Finnish Canc Registry, Helsinki, Finland (författare)
  • Mannisto, SatuNatl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland (författare)
  • Metter, E. JeffreyUniv Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA (författare)
  • Mikami, KazuyaKyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Urol, Kyoto, Japan (författare)
  • Milne, Roger L.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia (författare)
  • Ozasa, KotaroRadiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan (författare)
  • Platz, Elizabeth A.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA (författare)
  • Quiros, J. RamonPubl Hlth Directorate, Asturias, Spain (författare)
  • Rissanen, HarriNatl Inst Hlth & Welf, Helsinki, Finland (författare)
  • Sawada, NorieNatl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan (författare)
  • Stampfer, MeirHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA (författare)
  • Stanczyk, Frank Z.Univ Southern Calif, Keck Sch Med, Div Reprod Endocrinol & Infertil, Los Angeles, CA USA (författare)
  • Stattin, PärUppsala universitet,Urologkirurgi(Swepub:uu)parst892 (författare)
  • Tamakoshi, AkikoHokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan (författare)
  • Tangen, Catherine M.Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA (författare)
  • Thompson, Ian M.Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA (författare)
  • Tsilidis, Konstantinos K.Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece (författare)
  • Tsugane, ShoichiroNatl Canc Ctr, Epidemiol & Prevent Grp, Ctr Publ Hlth Sci, Tokyo, Japan (författare)
  • Ursin, GiskeInst Epidemiol Canc Res, Canc Registry Norway, Oslo, Norway;Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway;Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA (författare)
  • Vatten, LarsNorwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth, Trondheim, Norway (författare)
  • Weiss, Noel S.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA (författare)
  • Yeap, Bu B.Univ Western Australia, Sch Med, Perth, WA, Australia;Fiona Stanley Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia (författare)
  • Allen, Naomi E.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England (författare)
  • Key, Timothy J.Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England (författare)
  • Travis, Ruth C.Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England (författare)
  • Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, EnglandNatl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands;Imperial Coll London, Dept Epidemiol & Biostat, London, England;Univ Malaya, Dept Social & Prevent Med, Kuala Lumpur, Malaysia (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Urology: Elsevier74:5, s. 585-5940302-28381873-7560

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