A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels

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Lunzer, MarkusTU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163-MC, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)

Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one-and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.

Shi, LiyangUppsala universitet,Polymerkemi(Swepub:uu)liysh777 (författare)
Andriotis, Orestis G.TU Wien, Inst Lightweight Design & Struct Biomech, Getreidemarkt 9-317, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
Gruber, PeterTU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
Markovic, MaricaTU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
Thurner, Philipp J.TU Wien, Inst Lightweight Design & Struct Biomech, Getreidemarkt 9-317, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
Ossipov, Dmitri A.Karolinska Institutet,Uppsala universitet,Polymerkemi,Department of Biosciences and Nutrition, Karolinska Institutet Novum, Stockholm, Sweden(Swepub:uu)dos10703 (författare)
Liska, RobertTU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163-MC, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
Ovsianikov, AleksandrTU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria (författare)
TU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163-MC, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, AustriaPolymerkemi (creator_code:org_t)

Ingår i:Angewandte Chemie International Edition: WILEY-V C H VERLAG GMBH57:46, s. 15122-151271433-78511521-3773

Av författaren/redakt...: Lunzer, Markus; Shi, Liyang; Andriotis, Orest ...; Gruber, Peter; Markovic, Marica; Thurner, Philipp ...; visa fler...; Ossipov, Dmitri ...; Liska, Robert; Ovsianikov, Alek ...; visa färre...

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