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Sökning: WFRF:(Jack Clifford R.) > Forskningsöversikt > Kukull Walter A. > Limbic-predominant ...

  • Nelson, Peter T.Univ Kentucky, 311 Sanders Brown Ctr Aging, Lexington, KY 40536 USA (författare)

Limbic-predominant age-related TDP-43 encephalopathy (LATE) : consensus working group report

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-04-30
  • Oxford University Press (OUP),2019
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-393763
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393763URI
  • https://doi.org/10.1093/brain/awz099DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • A correction has been published: Brain, Volume 142, Issue 7, July 2019, Page e37, https://doi.org/10.1093/brain/awz163
  • We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a stereotypical TDP-43 proteinopathy in older adults, with or without coexisting hippocampal sclerosis pathology. LATE-NC is a common TDP-43 proteinopathy, associated with an amnestic dementia syndrome that mimicked Alzheimer's-type dementia in retrospective autopsy studies. LATE is distinguished from frontotemporal lobar degeneration with TDP-43 pathology based on its epidemiology (LATE generally affects older subjects), and relatively restricted neuroanatomical distribution of TDP-43 proteinopathy. In community-based autopsy cohorts, similar to 25% of brains had sufficient burden of LATE-NC to be associated with discernible cognitive impairment. Many subjects with LATE-NC have comorbid brain pathologies, often including amyloid-beta plaques and tauopathy. Given that the oldest-old' are at greatest risk for LATE-NC, and subjects of advanced age constitute a rapidly growing demographic group in many countries, LATE has an expanding but under-recognized impact on public health. For these reasons, a working group was convened to develop diagnostic criteria for LATE, aiming both to stimulate research and to promote awareness of this pathway to dementia. We report consensus-based recommendations including guidelines for diagnosis and staging of LATE-NC. For routine autopsy workup of LATE-NC, an anatomically-based preliminary staging scheme is proposed with TDP-43 immunohistochemistry on tissue from three brain areas, reflecting a hierarchical pattern of brain involvement: amygdala, hippocampus, and middle frontal gyrus. LATE-NC appears to affect the medial temporal lobe structures preferentially, but other areas also are impacted. Neuroimaging studies demonstrated that subjects with LATE-NC also had atrophy in the medial temporal lobes, frontal cortex, and other brain regions. Genetic studies have thus far indicated five genes with risk alleles for LATE-NC: GRN, TMEM106B, ABCC9, KCNMB2, and APOE. The discovery of these genetic risk variants indicate that LATE shares pathogenetic mechanisms with both frontotemporal lobar degeneration and Alzheimer's disease, but also suggests disease-specific underlying mechanisms. Large gaps remain in our understanding of LATE. For advances in prevention, diagnosis, and treatment, there is an urgent need for research focused on LATE, including in vitro and animal models. An obstacle to clinical progress is lack of diagnostic tools, such as biofluid or neuroimaging biomarkers, for ante-mortem detection of LATE. Development of a disease biomarker would augment observational studies seeking to further define the risk factors, natural history, and clinical features of LATE, as well as eventual subject recruitment for targeted therapies in clinical trials.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dickson, Dennis W.Mayo Clin, Jacksonville, FL 32224 USA (författare)
  • Trojanowski, John Q.Univ Penn, Philadelphia, PA 19104 USA (författare)
  • Jack, Clifford R., Jr.Mayo Clin, Rochester, MN USA (författare)
  • Boyle, Patricia A.Rush Univ, Med Ctr, Chicago, IL 60612 USA (författare)
  • Arfanakis, KonstantinosRush Univ, Med Ctr, Chicago, IL 60612 USA;IIT, Chicago, IL 60616 USA (författare)
  • Rademakers, RosaMayo Clin, Jacksonville, FL 32224 USA (författare)
  • Alafuzoff, IrinaUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)irial548 (författare)
  • Attems, JohannesNewcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England (författare)
  • Brayne, CarolUniv Cambridge, Cambridge, England (författare)
  • Coyle-Gilchrist, Ian T. S.Univ Cambridge, Cambridge, England (författare)
  • Chui, Helena C.Univ Southern Calif, Los Angeles, CA USA (författare)
  • Fardo, David W.Univ Kentucky, 311 Sanders Brown Ctr Aging, Lexington, KY 40536 USA (författare)
  • Flanagan, Margaret E.Univ Minnesota, Minneapolis, MN USA (författare)
  • Halliday, GlendaUniv Sydney, Brain & Mind Ctr, Sydney, NSW, Australia;Cent Clin Sch, Fac Med & Hlth, Sydney, NSW, Australia (författare)
  • Hokkanen, Suvi R. K.Univ Cambridge, Cambridge, England (författare)
  • Hunter, SallyUniv Cambridge, Cambridge, England (författare)
  • Jicha, Gregory A.Univ Kentucky, 311 Sanders Brown Ctr Aging, Lexington, KY 40536 USA (författare)
  • Katsumata, YurikoUniv Kentucky, 311 Sanders Brown Ctr Aging, Lexington, KY 40536 USA (författare)
  • Kawas, Claudia H.Univ Calif Irvine, Irvine, CA USA (författare)
  • Keene, C. DirkUniv Washington, Seattle, WA 98195 USA (författare)
  • Kovacs, Gabor G.Med Univ Vienna, Inst Neurol, Vienna, Austria (författare)
  • Kukull, Walter A.Univ Washington, Seattle, WA 98195 USA (författare)
  • Levey, Allan I.Emory Univ, Atlanta, GA 30322 USA (författare)
  • Makkinejad, NazaninIIT, Chicago, IL 60616 USA (författare)
  • Montine, Thomas J.Stanford Univ, Stanford, CA 94305 USA (författare)
  • Murayama, ShigeoTokyo Metropolitan Geriatr Hosp, Tokyo, Japan;Inst Gerontol, Tokyo, Japan (författare)
  • Murray, Melissa E.Mayo Clin, Jacksonville, FL 32224 USA (författare)
  • Nag, SukritiRush Univ, Med Ctr, Chicago, IL 60612 USA (författare)
  • Rissman, Robert A.Univ Calif San Diego, San Diego, CA 92103 USA;Harvard Univ, Cambridge, MA 02138 USA (författare)
  • Seeley, William W.Univ Calif San Francisco, San Francisco, CA 94143 USA (författare)
  • Sperling, Reisa A. (författare)
  • White, Charles L., IIIUniv Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA (författare)
  • Yu, LeiRush Univ, Med Ctr, Chicago, IL 60612 USA (författare)
  • Schneider, Julie A.Rush Univ, Med Ctr, Chicago, IL 60612 USA (författare)
  • Univ Kentucky, 311 Sanders Brown Ctr Aging, Lexington, KY 40536 USAMayo Clin, Jacksonville, FL 32224 USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Brain: Oxford University Press (OUP)142, s. 1503-15270006-89501460-2156

Internetlänk

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  • Brain (Sök värdpublikationen i LIBRIS)

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