Maintenance Tyrosine Kinase Inhibitors Following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia: A Center for International Blood and Marrow Transplant Research Study

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DeFilipp, Zachariah (author)

Maintenance Tyrosine Kinase Inhibitors Following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia : A Center for International Blood and Marrow Transplant Research Study

Article/chapterEnglish2020

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Elsevier,2020
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-402673
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-402673URI
https://doi.org/10.1016/j.bbmt.2019.10.017DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:143145300URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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It remains unknown whether the administration of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 after allogeneic hematopoietic cell transplantation (HCT) is associated with improved outcomes for patients with chronic myelogenous leukemia (CML). In this registry study, we analyzed clinical outcomes of 390 adult patients with CML who underwent transplantation between 2007 and 2014 and received maintenance TKI following HCT (n = 89) compared with no TKI maintenance (n = 301), as reported to the Center for International Blood and Marrow Transplant Research. All patients received TKI therapy before HCT. The majority of patients had a disease status of first chronic phase at HCT (n = 240; 62%). The study was conducted as a landmark analysis, excluding patients who died, relapsed, had chronic graft-versus-host disease, or were censored before day +100 following HCT. Of the 89 patients who received TKI maintenance, 77 (87%) received a single TKI and the other 12 (13%) received multiple sequential TKIs. The most common TKIs used for maintenance were dasatinib (n = 50), imatinib (n = 27), and nilotinib (n = 27). As measured from day +100, the adjusted estimates for 5-year relapse (maintenance, 35% versus no maintenance, 26%; P = .11), leukemia-free survival (maintenance, 42% versus no maintenance, 44%; P = .65), or overall survival (maintenance, 61% versus no maintenance, 57%; P = .61) did not differ significantly between patients receiving TKI maintenance or no maintenance. These results remained unchanged in multivariate analysis and were not modified by disease status before transplantation. In conclusion, our data from this day +100 landmark analysis do not demonstrate a significant impact of maintenance TKI therapy on clinical outcomes. The optimal approach to TKI administration in the post-transplantation setting in patients with CML remains undetermined.

Subject headings and genre

NATURVETENSKAP Biologi Immunologi hsv//swe
NATURAL SCIENCES Biological Sciences Immunology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
Allogeneic hematopoietic cell transplantation
Chronic myelogenous leukemia
Maintenance
Tyrosine kinase inhibitor

Added entries (persons, corporate bodies, meetings, titles ...)

Ancheta, Richard (author)
Liu, Ying (author)
Hu, Zhen-Huan (author)
Gale, Robert Peter (author)
Snyder, David (author)
Schouten, Harry C (author)
Kalaycio, Matt (author)
Hildebrandt, Gerhard C (author)
Ustun, Celalettin (author)
Daly, Andrew (author)
Ganguly, Siddhartha (author)
Inamoto, Yoshihiro (author)
Litzow, Mark (author)
Szer, Jeffrey (author)
Savoie, Mary Lynn (author)
Hossain, Nasheed (author)
Kharfan-Dabaja, Mohamed A (author)
Hamadani, Mehdi (author)
Reshef, RanKarolinska Institutet (author)
Bajel, Ashish (author)
Schultz, Kirk R (author)
Gadalla, Shahinaz (author)
Gerds, Aaron (author)
Liesveld, Jane (author)
Juckett, Mark B (author)
Kamble, Rammurti (author)
Hashmi, Shahrukh (author)
Abdel-Azim, Hisham (author)
Solh, Melhem (author)
Bacher, Ulrike (author)
Lazarus, Hillard (author)
Olsson, RichardUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)riols677 (author)
Cahn, Jean-Yves (author)
Grunwald, Michael R (author)
Savani, Bipin N (author)
Yared, Jean (author)
Rowe, Jacob M (author)
Cerny, Jan (author)
Chaudhri, Naeem A (author)
Aljurf, Mahmoud (author)
Beitinjaneh, Amer (author)
Seo, Sachiko (author)
Nishihori, Taiga (author)
Hsu, Jack W (author)
Ramanathan, Muthalagu (author)
Alyea, Edwin (author)
Popat, Uday (author)
Sobecks, Ronald (author)
Saber, Wael (author)
Karolinska InstitutetCentrum för klinisk forskning i Sörmland (CKFD) (creator_code:org_t)

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In:Biology of blood and marrow transplantation: Elsevier26:3, s. 472-4791083-87911523-6536

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By the author/editor: DeFilipp, Zachar ...; Ancheta, Richard; Liu, Ying; Hu, Zhen-Huan; Gale, Robert Pet ...; Snyder, David; show more...; Schouten, Harry ...; Kalaycio, Matt; Hildebrandt, Ger ...; Ustun, Celaletti ...; Daly, Andrew; Ganguly, Siddhar ...; Inamoto, Yoshihi ...; Litzow, Mark; Szer, Jeffrey; Savoie, Mary Lyn ...; Hossain, Nasheed; Kharfan-Dabaja, ...; Hamadani, Mehdi; Reshef, Ran; Bajel, Ashish; Schultz, Kirk R; Gadalla, Shahina ...; Gerds, Aaron; Liesveld, Jane; Juckett, Mark B; Kamble, Rammurti; Hashmi, Shahrukh; Abdel-Azim, Hish ...; Solh, Melhem; Bacher, Ulrike; Lazarus, Hillard; Olsson, Richard; Cahn, Jean-Yves; Grunwald, Michae ...; Savani, Bipin N; Yared, Jean; Rowe, Jacob M; Cerny, Jan; Chaudhri, Naeem ...; Aljurf, Mahmoud; Beitinjaneh, Ame ...; Seo, Sachiko; Nishihori, Taiga; Hsu, Jack W; Ramanathan, Muth ...; Alyea, Edwin; Popat, Uday; Sobecks, Ronald; Saber, Wael; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Immunology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

Articles in the publication: Biology of blood ...

By the university: Uppsala University; Karolinska Institutet

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