Tyck till om SwePub Sök
här!
Sökning: WFRF:(Sabater Lleal Maria) >
Organ-on-a-chip tec...
Organ-on-a-chip technology : a novel approach to investigate cardiovascular diseases
-
- Paloschi, Valentina (författare)
- Department for Vascular and Endovascular Surgery, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany;German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Berlin, Germany
-
- Sabater-Lleal, Maria (författare)
- Karolinska Institutet
-
- Middelkamp, Heleen (författare)
- BIOS/Lab on a Chip, University of Twente, Enschede, The Netherlands
-
visa fler...
-
- Vivas, Aisen (författare)
- BIOS/Lab on a Chip, University of Twente, Enschede, The Netherlands;Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands
-
- Johansson, Sofia (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Mikrosystemteknik,EMBLA
-
- van der Meer, Andries (författare)
- Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands
-
- Tenje, Maria (författare)
- Uppsala universitet,Mikrosystemteknik,Science for Life Laboratory, SciLifeLab,EMBLA
-
- Maegdefessel, Lars (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2021-03-17
- 2021
- Engelska.
-
Ingår i: Cardiovascular Research. - : Oxford University Press. - 0008-6363 .- 1755-3245. ; 117:14, s. 2742-2754
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. Several models of hearts-on-chips and vessels-on-chips have been demonstrated to recapitulate fundamental aspects of the human cardiovascular system in the recent past. These 2D and 3D systems include synchronized beating cardiomyocytes in hearts-on-chips and vessels-on-chips with layer-based structures and the inclusion of physiological and pathological shear stress conditions. The opportunities to discover novel targets and to perform drug testing with chip-based platforms have substantially enhanced, thanks to the utilization of patient-derived cells and precise control of their microenvironment. These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care. However, certain technical and biological challenges remain, making the global utilization of OoCs to tackle unanswered questions in cardiovascular science still rather challenging. This review article aims to introduce and summarize published work on hearts- and vessels-on chips but also to provide an outlook and perspective on how these advanced in vitro systems can be used to tailor disease models with patient-specific characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Organs-on-chips
- Cell culture
- Cardiovascular
- Heart
- Personalized medicine
- Teknisk fysik med inriktning mot mikrosystemteknik
- Engineering Science with specialization in Microsystems Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas