SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Bralten Janita)
 

Sökning: WFRF:(Bralten Janita) > Insulinopathies of ...

Insulinopathies of the brain? : Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Fanelli, Giuseppe (författare)
Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy.;Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
Franke, Barbara (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands.
De Witte, Ward (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
visa fler...
Ruisch, I. Hyun (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, Groningen, Netherlands.
Haavik, Jan (författare)
Univ Bergen, Dept Biomed, Bergen, Norway.;Haukeland Hosp, Div Psychiat, Bergen, Norway.
van Gils, Veerle (författare)
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
Jansen, Willemijn J. (författare)
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
Vos, Stephanie J. B. (författare)
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
Lind, Lars (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Buitelaar, Jan K. (författare)
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands.
Banaschewski, Tobias (författare)
Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany.
Dalsgaard, Soren (författare)
Aarhus Univ, Natl Ctr Register Based Res, Aarhus, Denmark.;Lundbeck Fdn Initiat Integrat Psychiat Res, PSYCH, Aarhus, Denmark.
Serretti, Alessandro (författare)
Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy.
Mota, Nina Roth (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
Poelmans, Geert (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
Bralten, Janita (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
visa färre...
Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy;Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands. Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands. (creator_code:org_t)
2022-02-14
2022
Engelska.
Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 12:1
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD). Dysregulation of insulin signalling has been implicated in these neuropsychiatric disorders, and shared genetic factors might partly underlie this observed multimorbidity. We investigated the genetic overlap between AD, ASD, and OCD with MetS, obesity, and T2DM by estimating pairwise global genetic correlations using the summary statistics of the largest available genome-wide association studies for these phenotypes. Having tested these hypotheses, other potential brain "insulinopathies" were also explored by estimating the genetic relationship of six additional neuropsychiatric disorders with nine insulin-related diseases/traits. Stratified covariance analyses were then performed to investigate the contribution of insulin-related gene sets. Significant negative genetic correlations were found between OCD and MetS (r(g) = -0.315, p = 3.9 x 10(-8)), OCD and obesity (r(g) = -0.379, p = 3.4 x 10(-5)), and OCD and T2DM (r(g) = -0.172, p = 3 x 10(-4)). Significant genetic correlations with insulin-related phenotypes were also found for anorexia nervosa (AN), attention-deficit/hyperactivity disorder (ADHD), major depressive disorder, and schizophrenia (p < 6.17 x 10(-4)). Stratified analyses showed negative genetic covariances between AD, ASD, OCD, ADHD, AN, bipolar disorder, schizophrenia and somatic insulinopathies through gene sets related to insulin signalling and insulin receptor recycling, and positive genetic covariances between AN and T2DM, as well as ADHD and MetS through gene sets related to insulin processing/secretion (p < 2.06 x 10(-4)). Overall, our findings suggest the existence of two dusters of neuropsychiatric disorders, in which the genetics of insulin-related diseases/traits may exert divergent pleiotropic effects. These results represent a starting point for a new research line on "insulinopathies" of the brain.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy