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Sökning: WFRF:(Li Yuan) > A D-peptide ligand ...

A D-peptide ligand of neuropeptide Y receptor Y-1 serves as nanocarrier traversing of the blood brain barrier and targets glioma

Li, Yanying (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Pan, Yuanbo (författare)
Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou 310003, Zhejiang, Peoples R China.
Wang, Yinjie (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
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Jiang, Zhenqi (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
Akakuru, Ozioma U. (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Li, Mingli (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Zhang, Xianyun (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
Yuan, Bo (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
Xing, Jie (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Luo, Lijia (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
Larhammar, Dan, 1956- (författare)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Larhammar: Farmakologi
Wu, Aiguo (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
Li, Juan (författare)
Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China.
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Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, Zhejiang Engn Res Ctr Biomed Mat,CAS Key Lab Magne, Ningbo 315201, Peoples R China;Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou 310003, Zhejiang, Peoples R China. (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: Nano Today. - : Elsevier. - 1748-0132 .- 1878-044X. ; 44
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Diseases of the central nervous system (CNS) are challenging for drug treatment because the blood-brain barrier (BBB) restricts entry of drugs into the brain tissue. Therefore, strategies for drug transport across the BBB are an important component in development of CNS drug therapies. Here, a D-amino acid ligand of the neuropeptide Y (NPY) receptor Y1 is described, (D)[Asn(28), Pro(30), Trp(32)]-DNPY (25-36) (termed DAPT), with 2.5 times higher number of hydrogen bonds interacting with the receptor, based on docking into a structural model, than the corresponding peptide with standard L-amino acids (LAPT). Using in vitro BBB models, in vivo healthy mice with intact BBB, and U87-MG orthotopic tumor-bearing mice, we demonstrate that DAPT exhibits significantly higher ability than LAPT to serve as nanocarrier across the BBB and specifically targets gliomas. Using DAPT nanomicelles loaded with IRDye780, it was possible to achieve excellent photothermal therapeutic and photoacoustic cancer imaging. Thus, this study demonstrates the importance of ligand stability and affinity in Y1 receptor-mediated transcytosis and paves the way for versatile brain tumor imaging and therapy using nanomicelles.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Nyckelord

D-amino acid peptide
Blood brain barrier
Transcytosis
Glioma
Y-1 receptor

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