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Global Effect of Mo...
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Magnussen, ChristinaUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
(författare)
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Massachusetts Medical Society,2023
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-520627
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520627URI
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https://doi.org/10.1056/nejmoa2206916DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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A list of the investigators in the Global Cardiovascular Risk Consortium is provided in the Supplementary Appendix, available at NEJM.org.
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Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)Harmonized individual-level data from a global cohort showed that more than half the cases of incident cardiovascular disease and one fifth of deaths may be attributable to five modifiable risk factors.
Ämnesord och genrebeteckningar
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Cardiovascular disease
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Cardiovascular risk factors
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Risk factor modification
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Global
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Population-attributable fraction
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Geographical comparison
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Myocardial infarction
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Coronary heart disease
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Stroke
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Heart disease
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Nutrition
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Nutrition
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Nutrition
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Nutrition
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ojeda, Francisco M.Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
(författare)
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Leong, Darryl P.McMaster Univ, Dept Med Cardiol, Hamilton, ON, Canada
(författare)
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Alegre-Diaz, Jesus
(författare)
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Amouyel, PhilippeUniv Lille, INSERM, Ctr Hosp Univ Lille,Epidemiol & Public Hlth Dept, Inst Pasteur Lille,UMR1167 RID AGE Risk Factors &, Lille, France
(författare)
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Aviles-Santa, LarissaNatl Inst Minor Hlth & Hlth Dispar, Div Clin & Hlth Serv Res, NIH, Bethesda, MD USA
(författare)
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De Bacquer, DirkUniv Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium
(författare)
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Ballantyne, Christie M.Baylor Coll Med, Dept Med, Houston, TX USA
(författare)
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Bernabé-Ortiz, AntonioUniv Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Lima, Peru
(författare)
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Bobak, MartinUCL, Dept Epidemiol & Publ Hlth, London, England
(författare)
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Brenner, HermannHeidelberg Univ, Network Aging Res, Heidelberg, Germany
(författare)
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Carrillo-Larco, Rodrigo M.Emory Univ, Rollins Sch Publ Hlth, Emory Global Diabet Res Ctr, Atlanta, GA USA;Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA
(författare)
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de Lemos, JamesUniv Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA;Univ Nacl Autonoma Mexico, Expt Med Res Unit, Sch Med, Mexico City, DF, Mexico
(författare)
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Dobson, AnnetteUniv Queensland, Sch Publ Hlth, Brisbane, Qld, Australia
(författare)
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Dörr, MarcusUniv Med Greifswald, Dept Internal Med B, Greifswald, Germany;Greifswald Medical School; DZHK Partner Site Greifswald, Greifswald, Germany
(författare)
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Donfrancesco, ChiaraIst Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Rome, Italy
(författare)
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Drygas, WojciechNatl Inst Cardiol, Dept Epidemiol Cardiovasc Dis Prevent & Hlth Prom, Warsaw, Poland;Lazarski Univ, Warsaw, Poland
(författare)
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Dullaart, Robin P.Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands
(författare)
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Engström, GunnarLund Univ, Dept Clin Sci Malmö, Malmö, Sweden
(författare)
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Ferrario, Marco M.Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy
(författare)
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Ferrières, JeanToulouse Rangueil Univ Hosp, INSERM, UMR1295, Dept Cardiol, Toulouse, France
(författare)
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de Gaetano, GiovanniIRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
(författare)
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Goldbourt, UriTel Aviv Univ, Dept Epidemiol, Sch Publ Hlth, Tel Aviv, Israel
(författare)
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Gonzalez, ClicerioInst Nacl Salud Publ, Ctr Estudios Diabet, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico
(författare)
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Grassi, GuidoUniv Milano Bicocca, Med Clin, Milan, Italy
(författare)
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Hodge, Allison M.Canc Council Victoria, Div Canc Epidemiol, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia
(författare)
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Hveem, KristianNorwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, HUNT Trondelag Hlth Study Res Ctr, Levanger, Norway;KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway
(författare)
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Iacoviello, LiciaUniv Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy;IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy
(författare)
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Ikram, M. KamranErasmus MC, Dept Neurol, Rotterdam, Netherlands;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
(författare)
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Irazola, VilmaInst Clin Effectiveness & Hlth Policy, Dept Chron Dis, Buenos Aires, DF, Argentina
(författare)
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Jobe, ModouLondon Sch Hyg & Trop Med, Med Res Council Unit Gambia, Banjul, Gambia
(författare)
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Jousilahti, PekkaFinnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
(författare)
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Kaleebu, PontianoUganda Virus Res Inst, Med Res Council, Entebbe, Uganda;London Sch Hyg & Trop Med, Uganda Res Unit, Entebbe, Uganda
(författare)
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Kavousi, MaryamErasmus MC, Dept Epidemiol, Rotterdam, Netherlands
(författare)
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Kee, FrankQueens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
(författare)
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Khalili, DavoodShahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran
(författare)
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Koenig, WolfgangGerman Heart Ctr, DZHK Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Munich, Germany:Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany
(författare)
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Kontsevaya, AnnaMinist Healthcare Russian Federat, Natl Res Ctr Therapy & Prevent Med, Moscow, Russia
(författare)
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Kuulasmaa, KariFinnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
(författare)
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Lackner, Karl J.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany;DZHK Partner Site Rhine Main, Mainz, Germany
(författare)
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Leistner, David M.Univ Heart & Vasc Ctr Frankfurt, DZHK Partner Site Rhine Main, Frankfurt, Germany
(författare)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind
(författare)
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Linneberg, AllanUniv Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
(författare)
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Lorenz, ThiessUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
(författare)
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Lyngbakken, Magnus NakremAkershus Univ Hosp, Div Med, Dept Cardiol, Lorenskog, Norway;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Cardiac Biomarkers, Fac Med, Oslo, Norway
(författare)
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Malekzadeh, RezaUniv Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Liver & Pancreaticobiliary Dis Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Oncol Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran
(författare)
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Malyutina, SofiaRussian Acad Sci, Res Inst Internal & Prevent Med, Branch Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia
(författare)
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Mathiesen, Ellisiv B.Arctic Univ Norway, Univ Tromso, Dept Clin Med, Tromso, Norway
(författare)
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Melander, OlleLund Univ, Dept Clin Sci Malmö, Malmö, Sweden
(författare)
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Metspalu, AndresUniv Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia
(författare)
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Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(författare)
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Blankenberg, StefanUniv Med Ctr Hamburg Eppendorf, Dept Cardiol, Univ Heart & Vasc Ctr, Ctr Populat Hlth Innovat, Martinistr 52, D-20246 Hamburg, Germany University of Hamburg;University Medical Center Hamburg-Eppendorf
(författare)
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Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, GermanyUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:New England Journal of Medicine: Massachusetts Medical Society389:14, s. 1273-12850028-47931533-4406
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Magnussen, Chris ...
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Ojeda, Francisco ...
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Leong, Darryl P.
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Alegre-Diaz, Jes ...
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Amouyel, Philipp ...
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Aviles-Santa, La ...
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De Bacquer, Dirk
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de Lemos, James
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Drygas, Wojciech
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Engström, Gunnar
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Goldbourt, Uri
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Hveem, Kristian
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