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  • Magnussen, ChristinaUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany (författare)

Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Massachusetts Medical Society,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-520627
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520627URI
  • https://doi.org/10.1056/nejmoa2206916DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • A list of the investigators in the Global Cardiovascular Risk Consortium is provided in the Supplementary Appendix, available at NEJM.org.
  • Background Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.Methods We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.Results Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).Conclusions Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.)Harmonized individual-level data from a global cohort showed that more than half the cases of incident cardiovascular disease and one fifth of deaths may be attributable to five modifiable risk factors.

Ämnesord och genrebeteckningar

  • Cardiovascular disease
  • Cardiovascular risk factors
  • Risk factor modification
  • Global
  • Population-attributable fraction
  • Geographical comparison
  • Myocardial infarction
  • Coronary heart disease
  • Stroke
  • Heart disease
  • Nutrition
  • Nutrition
  • Nutrition
  • Nutrition

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ojeda, Francisco M.Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany (författare)
  • Leong, Darryl P.McMaster Univ, Dept Med Cardiol, Hamilton, ON, Canada (författare)
  • Alegre-Diaz, Jesus (författare)
  • Amouyel, PhilippeUniv Lille, INSERM, Ctr Hosp Univ Lille,Epidemiol & Public Hlth Dept, Inst Pasteur Lille,UMR1167 RID AGE Risk Factors &, Lille, France (författare)
  • Aviles-Santa, LarissaNatl Inst Minor Hlth & Hlth Dispar, Div Clin & Hlth Serv Res, NIH, Bethesda, MD USA (författare)
  • De Bacquer, DirkUniv Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium (författare)
  • Ballantyne, Christie M.Baylor Coll Med, Dept Med, Houston, TX USA (författare)
  • Bernabé-Ortiz, AntonioUniv Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Lima, Peru (författare)
  • Bobak, MartinUCL, Dept Epidemiol & Publ Hlth, London, England (författare)
  • Brenner, HermannHeidelberg Univ, Network Aging Res, Heidelberg, Germany (författare)
  • Carrillo-Larco, Rodrigo M.Emory Univ, Rollins Sch Publ Hlth, Emory Global Diabet Res Ctr, Atlanta, GA USA;Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA (författare)
  • de Lemos, JamesUniv Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA;Univ Nacl Autonoma Mexico, Expt Med Res Unit, Sch Med, Mexico City, DF, Mexico (författare)
  • Dobson, AnnetteUniv Queensland, Sch Publ Hlth, Brisbane, Qld, Australia (författare)
  • Dörr, MarcusUniv Med Greifswald, Dept Internal Med B, Greifswald, Germany;Greifswald Medical School; DZHK Partner Site Greifswald, Greifswald, Germany (författare)
  • Donfrancesco, ChiaraIst Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Rome, Italy (författare)
  • Drygas, WojciechNatl Inst Cardiol, Dept Epidemiol Cardiovasc Dis Prevent & Hlth Prom, Warsaw, Poland;Lazarski Univ, Warsaw, Poland (författare)
  • Dullaart, Robin P.Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands (författare)
  • Engström, GunnarLund Univ, Dept Clin Sci Malmö, Malmö, Sweden (författare)
  • Ferrario, Marco M.Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy (författare)
  • Ferrières, JeanToulouse Rangueil Univ Hosp, INSERM, UMR1295, Dept Cardiol, Toulouse, France (författare)
  • de Gaetano, GiovanniIRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy (författare)
  • Goldbourt, UriTel Aviv Univ, Dept Epidemiol, Sch Publ Hlth, Tel Aviv, Israel (författare)
  • Gonzalez, ClicerioInst Nacl Salud Publ, Ctr Estudios Diabet, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico (författare)
  • Grassi, GuidoUniv Milano Bicocca, Med Clin, Milan, Italy (författare)
  • Hodge, Allison M.Canc Council Victoria, Div Canc Epidemiol, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia (författare)
  • Hveem, KristianNorwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, HUNT Trondelag Hlth Study Res Ctr, Levanger, Norway;KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway (författare)
  • Iacoviello, LiciaUniv Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy;IRCCS Neuromed, Dept Epidemiol & Prevent, Pozzilli, Italy (författare)
  • Ikram, M. KamranErasmus MC, Dept Neurol, Rotterdam, Netherlands;Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands (författare)
  • Irazola, VilmaInst Clin Effectiveness & Hlth Policy, Dept Chron Dis, Buenos Aires, DF, Argentina (författare)
  • Jobe, ModouLondon Sch Hyg & Trop Med, Med Res Council Unit Gambia, Banjul, Gambia (författare)
  • Jousilahti, PekkaFinnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland (författare)
  • Kaleebu, PontianoUganda Virus Res Inst, Med Res Council, Entebbe, Uganda;London Sch Hyg & Trop Med, Uganda Res Unit, Entebbe, Uganda (författare)
  • Kavousi, MaryamErasmus MC, Dept Epidemiol, Rotterdam, Netherlands (författare)
  • Kee, FrankQueens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland (författare)
  • Khalili, DavoodShahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran (författare)
  • Koenig, WolfgangGerman Heart Ctr, DZHK Partner Site Munich Heart Alliance, Munich, Germany;Tech Univ Munich, Munich, Germany:Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany (författare)
  • Kontsevaya, AnnaMinist Healthcare Russian Federat, Natl Res Ctr Therapy & Prevent Med, Moscow, Russia (författare)
  • Kuulasmaa, KariFinnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland (författare)
  • Lackner, Karl J.Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany;DZHK Partner Site Rhine Main, Mainz, Germany (författare)
  • Leistner, David M.Univ Heart & Vasc Ctr Frankfurt, DZHK Partner Site Rhine Main, Frankfurt, Germany (författare)
  • Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind (författare)
  • Linneberg, AllanUniv Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark (författare)
  • Lorenz, ThiessUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany (författare)
  • Lyngbakken, Magnus NakremAkershus Univ Hosp, Div Med, Dept Cardiol, Lorenskog, Norway;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Cardiac Biomarkers, Fac Med, Oslo, Norway (författare)
  • Malekzadeh, RezaUniv Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Liver & Pancreaticobiliary Dis Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Oncol Res Ctr, Tehran, Iran;Univ Tehran Med Sci, Digest Dis Res Inst, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran (författare)
  • Malyutina, SofiaRussian Acad Sci, Res Inst Internal & Prevent Med, Branch Fed Res Ctr Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia (författare)
  • Mathiesen, Ellisiv B.Arctic Univ Norway, Univ Tromso, Dept Clin Med, Tromso, Norway (författare)
  • Melander, OlleLund Univ, Dept Clin Sci Malmö, Malmö, Sweden (författare)
  • Metspalu, AndresUniv Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia (författare)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
  • Blankenberg, StefanUniv Med Ctr Hamburg Eppendorf, Dept Cardiol, Univ Heart & Vasc Ctr, Ctr Populat Hlth Innovat, Martinistr 52, D-20246 Hamburg, Germany University of Hamburg;University Medical Center Hamburg-Eppendorf (författare)
  • Univ Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany;German Canc Res Ctr, German Ctr Cardiovasc Res DZHK Partner Site Hambu, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, GermanyUniv Heart & Vasc Ctr Hamburg, Ctr Populat Hlth Innovat, Hamburg, Germany;Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:New England Journal of Medicine: Massachusetts Medical Society389:14, s. 1273-12850028-47931533-4406

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