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Response Surface Me...
Response Surface Methodology (RSM) approach to formulate and optimize the bilayer combination tablet of Tamsulosin and Finasteride
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- Akhtar, Muneeba (författare)
- Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan.
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- Zaman, Muhammad (författare)
- Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan.
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- Siddiqi, Ahsan Zamir (författare)
- Highnoon Labs Ltd, Lahore, Pakistan.;Uppsala Univ, Fac Pharm, Dept Med Chem, S-75123 Uppsala, Sweden.
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- Ali, Hasan (författare)
- Highnoon Labs Ltd, Lahore, Pakistan.;Uppsala Univ, Fac Pharm, Dept Med Chem, S-75123 Uppsala, Sweden.
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- Khan, Rahima (författare)
- Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan.
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- Alvi, Muhammad Nadeem (författare)
- Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan.
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- Butt, Muhammad Hammad (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- El-Demerdash, Fatma M. (författare)
- Alexandria Univ, Inst Grad Studies & Res, Dept Environm Studies, Alexandria, Egypt.;Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia.
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- Binjawhar, Dalal Nasser (författare)
- Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia.
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- Sayed, Amany A. (författare)
- Cairo Univ, Fac Sci, Zool Dept, Giza 12613, Egypt.
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- Altyar, Ahmed E. (författare)
- King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, POB 80260, Jeddah 21589, Saudi Arabia.;Batterjee Med Coll, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia.
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- Abdel-Daim, Mohamed M. (författare)
- Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia.;Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt.
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Univ Cent Punjab, Fac Pharmaceut Sci, Lahore, Pakistan Highnoon Labs Ltd, Lahore, Pakistan.;Uppsala Univ, Fac Pharm, Dept Med Chem, S-75123 Uppsala, Sweden. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Saudi Pharmaceutical Journal. - : Elsevier. - 1319-0164 .- 2213-7475. ; 32:3
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- An orally administered bilayer tablet with Tamsulosin (TAM) as the sustained release (SR) and Finasteride (FIN) as immediate release (IR) was manufactured. A response surface methodology was employed to formulate bilayer tablets with individual release layers, i.e., sustained and immediate release (SR and IR). Independent variables selected in both cases comprise hydroxypropyl methylcellulose (HPMC) as SR polymer, and avicel PH102 in the inner layer while Triacetin and talc in the outer layer, respectively. Tablets were prepared by direct compression, a total of 11 formulations were prepared for inner layer TAM, and 9 formulations for outer layer FIN were designed; these formulations were evaluated for hardness, friability, thickness, %drug content, and %drug release. A central composite design was employed in response surface methodology to design and optimize the formulation. The percentage of drug released was evaluated by in-vitro USP dissolution method of optimized formulation for 0.5, 2, and 6 hrs, and results were 24.63, 52.96, and 97.68 %, respectively. Drug release data was plotted in various kinetic models using a D.D solver, where drug release was first order that is concentration dependent and was best explained by Korsmeyer–Peppa kinetics, as the highest linearity was observed (R2 = 0.9693). However, a very close relationship was also noted with Higuchi kinetics (R2 = 0.9358). The mechanism of drug release was determined through the Korsmeyer model, and exponent "n" was found to be 0.4, indicative of an anomalous diffusion mechanism or diffusion coupled with erosion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Tamsulosin
- Finasteride
- Response Surface Methodology
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- art (ämneskategori)
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- Av författaren/redakt...
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Akhtar, Muneeba
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Zaman, Muhammad
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Siddiqi, Ahsan Z ...
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Ali, Hasan
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Khan, Rahima
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Alvi, Muhammad N ...
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visa fler...
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Butt, Muhammad H ...
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El-Demerdash, Fa ...
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Binjawhar, Dalal ...
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Sayed, Amany A.
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Altyar, Ahmed E.
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Abdel-Daim, Moha ...
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visa färre...
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Uppsala universitet