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  • Sandblom, GLinköpings universitet,Uppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery,Urologi,Hälsouniversitetet (author)

Prostate-specific antigen as surrogate for characterizing prostate cancer subgroups

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • Informa UK Limited,2002
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-80421
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-80421URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-6516URI
  • https://doi.org/10.1080/003655902753679382DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25340URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE To evaluate how serum prostate-specific antigen (PSA) levels in a population-based cohort of men with prostate cancer vary with age and intensity in the diagnostic activity and to describe the treatment selection processes associated with PSA level. MATERIAL AND METHODS All men in the Swedish National Prostate Cancer Register diagnosed during 1996-1997 were included. In 1996 the register included 19 counties, covering 61% of the Swedish male population, and in 1997 21 counties with 79% of the Swedish male population. RESULTS A total of 8328 men were registered. PSA levels were missing in 341 cases. With increasing PSA there was a shift towards more advanced and poorly differentiated tumours. PSA at diagnosis increased with age, with the exception of patients younger than 50 years who had higher PSA values. The mean logarithm of PSA correlated negatively with the percentage of localized tumours (p < 0.005) and the age-adjusted incidence (p < 0.05) in each respective county in 1997. PSA was higher in men receiving radiotherapy compared with those treated with radical prostatectomy as well as in the group treated with bilateral orchiectomy compared with those receiving GnRH-analogues. CONCLUSIONS If PSA is used as a surrogate measure of extent of tumour volume in a population of prostate cancer patients, our findings indicate that age distribution and differences in incidence (possibly due to variation in diagnostic activity) should be taken into account. In our cohort there was a selection process, probably in part guided by PSA level, when choosing type of curative or palliative treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Holmberg, LarsUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery,Uppsala univeristet,Oncological Centre, Uppsala University, Sweden(Swepub:uu)larsholmb (author)
  • Damber, J-EDepartment of Urology, Sahlgrenska Hospital, Gothenburg, Sweden (author)
  • Hugosson, JDepartment of Urology, Sahlgrenska Hospital, Gothenburg, Sweden (author)
  • Johansson, J-EDepartment of Urology and Centre for Assessment of Medical Technology, Örebro Medical Centre, Sweden (author)
  • Lundgren, R5Department of Surgery/Section of Urology, Helsingborg Hospital, Sweden (author)
  • Mattsson, ElisabetUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Oncological Centre, Uppsala University, Sweden(Swepub:esh)elimat (author)
  • Nilsson, JOncological Centre, Uppsala University, Sweden (author)
  • Varenhorst, Eberhard,1937-Linköpings universitet,Urologi,Hälsouniversitetet(Swepub:liu)ebeva05 (author)
  • Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Urology and Nephrology: Informa UK Limited36:2, s. 106-1120036-55991651-2065

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