Analysis of ten candidate genes in autism by association and linkage

• We studied the possible involvement of ten candidate genes in autism: proenkephalin, prodynorphin, and proprotein convertase subtilisin/kexin type 2 (opioid metabolism); tyrosine hydroxylase, dopamine receptors D2 and D5, monoamine oxidases A and B (monoaminergic system); brain-derived neurotrophic factor, and neural cell adhesion molecule (involved in neurodevelopment). Thirty-eight families with two affected siblings and one family with two affected half-siblings, recruited by the Paris Autism Research International Sibpair Study (PARIS), were tested using the transmission disequilibrium test and two-point affected sib-pair linkage analysis. We found no evidence for association or linkage with intragenic or linked markers. Our family sample has good power for detecting a linkage disequilibrium of 0.80. Thus, these genes are unlikely to play a major role in the families studied, but further studies in a much larger sample would be needed to highlight weaker genetic effects.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Alleles

Autistic Disorder

Genetics

Chromosome Mapping

DNA

Genetics

Family Health

Female

Genetic Predisposition to Disease

Genetics

Genotype

Humans

Linkage Disequilibrium

Male

Microsatellite Repeats

Monoamine Oxidase

Genetics

Nuclear Family

Receptors

Dopamine

Genetics

Tyrosine 3-Monooxygenase

Genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)