Bridging the gap between systems biology and medicine

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Clermont, GillesUniversity of Pittsburgh School of Medicine, PA , USA (författare)

ABSTRACT : Systems biology has matured considerably as a discipline over the last decade, yet some of the key challenges separating current research efforts in systems biology and clinically useful results are only now becoming apparent. As these gaps are better defined, the new discipline of systems medicine is emerging as a translational extension of systems biology. How is systems medicine defined? What are relevant ontologies for systems medicine? What are the key theoretic and methodologic challenges facing computational disease modeling? How are inaccurate and incomplete data, and uncertain biologic knowledge best synthesized in useful computational models? Does network analysis provide clinically useful insight? We discuss the outstanding difficulties in translating a rapidly growing body of data into knowledge usable at the bedside. Although core-specific challenges are best met by specialized groups, it appears fundamental that such efforts should be guided by a roadmap for systems medicine drafted by a coalition of scientists from the clinical, experimental, computational, and theoretic domains.

Auffray, CharlesCNRS Institute of Biological Sciences, Villejuif Cedex, France (författare)
Moreau, YvesK.U. Leuven, ESAT/SCD, Leuven-Heverlee, Belgium (författare)
Rocke, David MUniversity of California, Davis, USA (författare)
Dalevi, Daniel,1974Chalmers tekniska högskola,Chalmers University of Technology,Chalmers and Göteborg University, Sweden(Swepub:cth)dalevi (författare)
Dubhashi, Devdatt,1965Chalmers tekniska högskola,Chalmers University of Technology,Chalmers and Göteborg University, Sweden(Swepub:cth)dubhashi (författare)
Marshall, Dana RMeharry Medical College, Nashville, TN , USA (författare)
Raasch, PeterUniversity of Rostock, Germany (författare)
Dehne, FrankCarleton University, Ottawa, Ontario, Canada (författare)
Provero, PaoloUniversity of Torino, Italy (författare)
Tegner, JesperKarolinska Institutet (författare)
Aronow, Bruce JUniversity of Cincinnati, OH, USA (författare)
Langston, Michael AUniversity of Tennessee, Knoxville, USA (författare)
Benson, Mikael,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg,The Unit for Clinical Systems Biology, The Queen Silvia Children's Hospital, Gothenburg, Sweden(Swepub:liu)mikbe05 (författare)
University of Pittsburgh School of Medicine, PA , USACNRS Institute of Biological Sciences, Villejuif Cedex, France (creator_code:org_t)

Av författaren/redakt...: Clermont, Gilles; Auffray, Charles; Moreau, Yves; Rocke, David M; Dalevi, Daniel, ...; Dubhashi, Devdat ...; visa fler...; Marshall, Dana R; Raasch, Peter; Dehne, Frank; Provero, Paolo; Tegner, Jesper; Aronow, Bruce J; Langston, Michae ...; Benson, Mikael, ...; visa färre...

Av lärosätet: Göteborgs universitet; Chalmers tekniska högskola; Linköpings universitet; Karolinska Institutet

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