Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

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Artigas Soler, María (author)

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Article/chapterEnglish2011

Publisher, publication year, extent ...

2011-09-25
Springer Science and Business Media LLC,2011

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LIBRIS-ID:oai:gup.ub.gu.se/149729
https://gup.ub.gu.se/publication/149729URI
https://doi.org/10.1038/ng.941DOI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

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Loth, Daan W (author)
Wain, Louise V (author)
Gharib, Sina A (author)
Obeidat, Ma'en (author)
Tang, Wenbo (author)
Zhai, Guangju (author)
Zhao, Jing Hua (author)
Smith, Albert Vernon (author)
Huffman, Jennifer E (author)
Albrecht, Eva (author)
Jackson, Catherine M (author)
Evans, David M (author)
Cadby, Gemma (author)
Fornage, Myriam (author)
Manichaikul, Ani (author)
Lopez, Lorna M (author)
Johnson, Toby (author)
Aldrich, Melinda C (author)
Aspelund, Thor (author)
Barroso, Inês (author)
Campbell, Harry (author)
Cassano, Patricia A (author)
Couper, David J (author)
Eiriksdottir, Gudny (author)
Franceschini, Nora (author)
Garcia, Melissa (author)
Gieger, Christian (author)
Gislason, Gauti Kjartan (author)
Grkovic, Ivica (author)
Hammond, Christopher J (author)
Hancock, Dana B (author)
Harris, Tamara B (author)
Ramasamy, Adaikalavan (author)
Heckbert, Susan R (author)
Heliövaara, Markku (author)
Homuth, Georg (author)
Hysi, Pirro G (author)
James, Alan L (author)
Jankovic, Stipan (author)
Joubert, Bonnie R (author)
Karrasch, Stefan (author)
Klopp, Norman (author)
Koch, Beate (author)
Kritchevsky, Stephen B (author)
Launer, Lenore J (author)
Liu, Yongmei (author)
Loehr, Laura R (author)
Lohman, Kurt (author)
Loos, Ruth J F (author)
Lumley, Thomas (author)
Al Balushi, Khalid A (author)
Ang, Wei Q (author)
Barr, R Graham (author)
Beilby, John (author)
Blakey, John D (author)
Boban, Mladen (author)
Boraska, Vesna (author)
Brisman, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xbrijo (author)
Britton, John R (author)
Brusselle, Guy G (author)
Cooper, Cyrus (author)
Curjuric, Ivan (author)
Dahgam, SantoshGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xdaghs (author)
Deary, Ian J (author)
Ebrahim, Shah (author)
Eijgelsheim, Mark (author)
Francks, Clyde (author)
Gaysina, Darya (author)
Granell, Raquel (author)
Gu, Xiangjun (author)
Hankinson, John L (author)
Hardy, Rebecca (author)
Harris, Sarah E (author)
Henderson, John (author)
Henry, Amanda (author)
Hingorani, Aroon D (author)
Hofman, Albert (author)
Holt, Patrick G (author)
Hui, Jennie (author)
Hunter, Michael L (author)
Imboden, Medea (author)
Jameson, Karen A (author)
Kerr, Shona M (author)
Kolcic, Ivana (author)
Kronenberg, Florian (author)
Liu, Jason Z (author)
Marchini, Jonathan (author)
McKeever, Tricia (author)
Morris, Andrew D (author)
Olin, Anna-Carin,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xolina (author)
Porteous, David J (author)
Postma, Dirkje S (author)
Rich, Stephen S (author)
Ring, Susan M (author)
Rivadeneira, Fernando (author)
Rochat, Thierry (author)
Sayer, Avan Aihie (author)
Sayers, Ian (author)
Sly, Peter D (author)
Smith, George Davey (author)
Sood, Akshay (author)
Starr, John M (author)
Uitterlinden, André G (author)
Vonk, Judith M (author)
Wannamethee, S Goya (author)
Whincup, Peter H (author)
Wijmenga, Cisca (author)
Williams, O Dale (author)
Wong, Andrew (author)
Mangino, Massimo (author)
Marciante, Kristin D (author)
McArdle, Wendy L (author)
Meibohm, Bernd (author)
Morrison, Alanna C (author)
North, Kari E (author)
Omenaas, Ernst (author)
Palmer, Lyle J (author)
Pietiläinen, Kirsi H (author)
Pin, Isabelle (author)
Pola Sbreve Ek, Ozren (author)
Pouta, Anneli (author)
Psaty, Bruce M (author)
Hartikainen, Anna-Liisa (author)
Rantanen, Taina (author)
Ripatti, Samuli (author)
Rotter, Jerome I (author)
Rudan, Igor (author)
Rudnicka, Alicja R (author)
Schulz, Holger (author)
Shin, So-Youn (author)
Spector, Tim D (author)
Surakka, Ida (author)
Vitart, Veronique (author)
Völzke, Henry (author)
Wareham, Nicholas J (author)
Warrington, Nicole M (author)
Wichmann, H-Erich (author)
Wild, Sarah H (author)
Wilk, Jemma B (author)
Wjst, Matthias (author)
Wright, Alan F (author)
Zgaga, Lina (author)
Zemunik, Tatijana (author)
Pennell, Craig E (author)
Nyberg, Fredrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xnybef (author)
Kuh, Diana (author)
Holloway, John W (author)
Boezen, H Marike (author)
Lawlor, Debbie A (author)
Morris, Richard W (author)
Probst-Hensch, Nicole (author)
Kaprio, Jaakko (author)
Wilson, James F (author)
Hayward, Caroline (author)
Kähönen, Mika (author)
Heinrich, Joachim (author)
Musk, Arthur W (author)
Jarvis, Deborah L (author)
Gläser, Sven (author)
Järvelin, Marjo-Riitta (author)
Ch Stricker, Bruno H (author)
Elliott, Paul (author)
O'Connor, George T (author)
Strachan, David P (author)
London, Stephanie J (author)
Hall, Ian P (author)
Gudnason, Vilmundur (author)
International Lung Cancer Consortium, (author)
Tobin, Martin D (author)
GIANT Consortium, (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa (creator_code:org_t)

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In:Nature genetics: Springer Science and Business Media LLC43:11, s. 1082-901546-17181061-4036

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By the author/editor: Artigas Soler, M ...; Loth, Daan W; Wain, Louise V; Gharib, Sina A; Obeidat, Ma'en; Tang, Wenbo; show more...; Zhai, Guangju; Zhao, Jing Hua; Smith, Albert Ve ...; Huffman, Jennife ...; Albrecht, Eva; Jackson, Catheri ...; Evans, David M; Cadby, Gemma; Fornage, Myriam; Manichaikul, Ani; Lopez, Lorna M; Johnson, Toby; Aldrich, Melinda ...; Aspelund, Thor; Barroso, Inês; Campbell, Harry; Cassano, Patrici ...; Couper, David J; Eiriksdottir, Gu ...; Franceschini, No ...; Garcia, Melissa; Gieger, Christia ...; Gislason, Gauti ...; Grkovic, Ivica; Hammond, Christo ...; Hancock, Dana B; Harris, Tamara B; Ramasamy, Adaika ...; Heckbert, Susan ...; Heliövaara, Mark ...; Homuth, Georg; Hysi, Pirro G; James, Alan L; Jankovic, Stipan; Joubert, Bonnie ...; Karrasch, Stefan; Klopp, Norman; Koch, Beate; Kritchevsky, Ste ...; Launer, Lenore J; Liu, Yongmei; Loehr, Laura R; Lohman, Kurt; Loos, Ruth J F; Lumley, Thomas; Al Balushi, Khal ...; Ang, Wei Q; Barr, R Graham; Beilby, John; Blakey, John D; Boban, Mladen; Boraska, Vesna; Brisman, Jonas, ...; Britton, John R; Brusselle, Guy G; Cooper, Cyrus; Curjuric, Ivan; Dahgam, Santosh; Deary, Ian J; Ebrahim, Shah; Eijgelsheim, Mar ...; Francks, Clyde; Gaysina, Darya; Granell, Raquel; Gu, Xiangjun; Hankinson, John ...; Hardy, Rebecca; Harris, Sarah E; Henderson, John; Henry, Amanda; Hingorani, Aroon ...; Hofman, Albert; Holt, Patrick G; Hui, Jennie; Hunter, Michael ...; Imboden, Medea; Jameson, Karen A; Kerr, Shona M; Kolcic, Ivana; Kronenberg, Flor ...; Liu, Jason Z; Marchini, Jonath ...; McKeever, Tricia; Morris, Andrew D; Olin, Anna-Carin ...; Porteous, David ...; Postma, Dirkje S; Rich, Stephen S; Ring, Susan M; Rivadeneira, Fer ...; Rochat, Thierry; Sayer, Avan Aihi ...; Sayers, Ian; Sly, Peter D; Smith, George Da ...; Sood, Akshay; Starr, John M; Uitterlinden, An ...; Vonk, Judith M; Wannamethee, S G ...; Whincup, Peter H; Wijmenga, Cisca; Williams, O Dale; Wong, Andrew; Mangino, Massimo; Marciante, Krist ...; McArdle, Wendy L; Meibohm, Bernd; Morrison, Alanna ...; North, Kari E; Omenaas, Ernst; Palmer, Lyle J; Pietiläinen, Kir ...; Pin, Isabelle; Pola Sbreve Ek, ...; Pouta, Anneli; Psaty, Bruce M; Hartikainen, Ann ...; Rantanen, Taina; Ripatti, Samuli; Rotter, Jerome I; Rudan, Igor; Rudnicka, Alicja ...; Schulz, Holger; Shin, So-Youn; Spector, Tim D; Surakka, Ida; Vitart, Veroniqu ...; Völzke, Henry; Wareham, Nichola ...; Warrington, Nico ...; Wichmann, H-Eric ...; Wild, Sarah H; Wilk, Jemma B; Wjst, Matthias; Wright, Alan F; Zgaga, Lina; Zemunik, Tatijan ...; Pennell, Craig E; Nyberg, Fredrik, ...; Kuh, Diana; Holloway, John W; Boezen, H Marike; Lawlor, Debbie A; Morris, Richard ...; Probst-Hensch, N ...; Kaprio, Jaakko; Wilson, James F; Hayward, Carolin ...; Kähönen, Mika; Heinrich, Joachi ...; Musk, Arthur W; Jarvis, Deborah ...; Gläser, Sven; Järvelin, Marjo- ...; Ch Stricker, Bru ...; Elliott, Paul; O'Connor, George ...; Strachan, David ...; London, Stephani ...; Hall, Ian P; Gudnason, Vilmun ...; International Lu ...; Tobin, Martin D; GIANT Consortium ...; show less...

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