Blood flow in liver tumors--effects of vasoactive drugs estimated with xenon (133Xe) clearance.

• The aim of the present study was to identify in a standardized experimental rat liver tumor system the drugs which are most appropriate in influencing the relationship between liver tumor and normal liver parenchyma blood flow as estimated with 133Xe washout clearance method, and thereby positively influencing the kinetics of chemotherapeutic drugs. A battery of vasoactive drugs, which according to a literature review were considered to be active, were tested.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Animals

Liver Neoplasms

blood supply

metabolism

Rats

Rats

Wistar

Regional Blood Flow

drug effects

Vasoconstrictor Agents

pharmacology

Xenon Radioisotopes

pharmacokinetics

Animals

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)